Reference on EC 2.7.1.137 - phosphatidylinositol 3-kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.
Synthesis and function of 3-phosphorylated inositol lipids
Annu. Rev. Biochem.
70
535-602
2001
Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (O14356), Schizosaccharomyces pombe (P50520), Schizosaccharomyces pombe (Q9Y7K2)
Huang, M.E.; Manus, V.; Chuat, J.C.; Galibert, F.
Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI
Yeast
12
869-875
1996
Saccharomyces cerevisiae (P35169)
Vanhaesebroeck, B.; Welham, M.J.; Kotani, K.; Stein, R.; Warne, P.H.; Zvelebil, M.J.; Higashi, K.; Volinia, S.; Downward, J.; Waterfield, M.D.
P110delta, a novel phosphoinositide 3-kinase in leukocytes
Proc. Natl. Acad. Sci. USA
94
4330-4335
1997
Homo sapiens (O00329)
Shibasaki, F.; Homma, Y.; Takenawa, T.
Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form
J. Biol. Chem.
266
8108-8114
1991
Bos taurus
Herbst, J.J.; Andrews, G.; Contillo, L.; Lamphere, L.; Gardner, J.; Lienhard, G.E.; Gibbs, E.M.
Potent activation of phosphatidylinositol 3-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains
Biochemistry
33
9376-9381
1994
Rattus norvegicus
Morgan, S.J.; Smith, A.D.; Parker, P.J.
Purification and characterization of bovine brain type I phosphatidylinositol kinase
Eur. J. Biochem.
191
761-767
1990
Bos taurus
Carpenter, C.L.; Duckworth, B.C.; Auger, K.R.; Cohen, B.; Schaffhausen, B.S.; Cantley, L.C.
Purification and characterization of phosphoinositide 3-kinase from rat liver
J. Biol. Chem.
265
19704-19711
1990
Rattus norvegicus
Fry, M.J.; Panayotou, G.; Dhand, R.; Ruiz-Larrea, F.; Gout, I.; Nguyen, O.; Courtneidge, S.A.; Waterfield, M.D.
Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns
Biochem. J.
288
383-393
1992
Bos taurus
-
Baxter, R.M.; Bramham, J.; Thomason, P.A.; Downes, C.P.; Carter, A.N.
Characterisation of phosphatidylinositol 3-kinase in PC12 cell extracts and isolation of the enzyme from rat brain extracts
Biochem. Soc. Trans.
21
359S
1993
Rattus norvegicus
Shibasaki, F.; Fukui, Y.; Takenawa, T.
Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases
Biochem. J.
289
227-231
1993
Bos taurus
-
Gout, I.; Dhand, R.; Panayotou, G.; Fry, M.J.; Hiles, I.; Otsu, M.; Waterfield, M.D.
Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system
Biochem. J.
288
395-405
1992
Bos taurus
-
Ruiz-Larrea, F.; Vicendo, P.; Yaish, P.; End, P.; Panayotou, G.; Fry, M.J.; Morgan, S.J.; Thompson, A.; Parker, P.J.; Waterfield, M.D.
Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex
Biochem. J.
290
609-616
1993
Bos taurus
-
Hiles, I.D.; Otsu, M.; Volinia, S.; Fry, M.J.; Gout, I.; Dhand, R.; Panayotou, G.; Ruiz-Larrea, F.; Thompson, A.; Totty, N.F.; Hsuan, J.J.; Courtneidge, S.A.; Parker, P.J.; Waterfield, M.D.
Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit
Cell
70
419-429
1992
Bos taurus, Bos taurus (P32871)
Ahmad, F.; Li, P.M.; Meyerovitch, J.; Goldstein, B.J.
Osmotic loading of neutralizing antibodies demonstrates a role of protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway
J. Biol. Chem.
270
20503-20508
1995
Rattus norvegicus
Aksoy, I.A.; Ramsey, M.J.; Fruman, D.A.; Aksoy, S.; Cantley, L.C.; Tucker, J.D.; Roberts, T.M.
Mouse Phosphoinositide 3-Kinase p110a Gene: Cloning, Structural Organization, and Localization to Chromosome 3 Band B
Biochem. Biophys. Res. Commun.
262
438-442
1999
Mus musculus
Anderwald, C.; Muller, G.; Koca, G.; Furnsinn, C.; Waldhausl, W.; Roden, M.
Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2
Mol. Endocrinol.
16
1612-1628
2002
Rattus norvegicus
Arcaro, A.; Zvelebil, M.J.; Wallasch, C.; Ullrich, A.; Waterfield, M.D.; Domin, J.
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
Mol. Cell. Biol.
20
3817-3830
2000
Homo sapiens
Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.
Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity
J. Biol. Chem.
273
33082-33090
1998
Homo sapiens, Homo sapiens (O00750)
Asano, T.; Kanda, A.; Katagiri, H.; Nawano, M.; Ogihara, T.; Inukai, K.; Anai, M.; Fukushima, Y.; Yazaki, Y.; Kikuchi, M.; Hooshmand-Rad, R.; Heldin, C.H.; Oka, Y.; Funaki, M.
p110b is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity
J. Biol. Chem.
275
17671-17676
2000
Rattus norvegicus
Axelsson, L.; Hellberg, C.; Melander, F.; Smith, D.; Zheng, L.; Andersson, T.
Clustering of b2-Integrins on Human Neutrophils Activates Dual Signaling Pathways to PtdIns 3-Kinase
Exp. Cell Res.
256
257-263
2000
Homo sapiens
Bartlett, S.E.; Reynolds, A.J.; Tan, T.; Heydon, K.; Hendry, I.A.
Differential mRNA expression and subcellular locations of PI3-kinase isoforms in sympathetic and sensory neurons
J. Neurosci. Res.
56
44-53
1999
Mus musculus
Bavelloni, A.; Santi, S.; Sirri, A.; Riccio, M.; Faenza, I.; Zini, N.; Cecchi, S.; Ferri, A.; Auron, P.; Maraldi, N.M.; Marmiroli, S.
Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells
J. Cell Sci.
112
631-640
1999
Homo sapiens
-
Baynes, K.C.R.; Beeton, C.A.; Panayotou, G.; Stein, R.; Soos, M.; Hansen, T.; Simpson, H.; O'Rahilly, S.; Shepherd, P.R.; Whitehead, J.P.
Natural variants of human p85a phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity
Diabetologia
43
321-331
2000
Homo sapiens
Beckwith, M.; Fenton, R.G.; Katona, I.M.; Longo, D.L.
Phosphatidylinositol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human b-lymphoma cell line
Blood
87
202-210
1996
Homo sapiens
Berggren, M.I.; Gallegos, A.; Dressler, L.A.; Modest, E.J.; Powis, G.
Inhibition of the signalling enzyme phosphatidylinositol-3-kinase by antitumor ether lipid analogs
Cancer Res.
53
4297-4302
1993
Bos taurus, Mus musculus
Bezerra, R.M.N.; Ueno, M.; Silva, M.S.; Tavares, D.Q.; Carvalho, C.R.O.; Saad, M.J.A.
A high fructose diet affects the early steps of insulin action in muscle and liver of rats
J. Nutr.
130
1531-1535
2000
Rattus norvegicus
Blondeau, F.; Laporte, J.; Bodin, S.; Superti-Furga, G.; Payrastre, B.; Mandel, J.L.
Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway
Hum. Mol. Genet.
9
2223-2229
2000
Homo sapiens, Rattus norvegicus
Carrillo, J.J.; Ibares, B.; Esteban-Gamboa, A.; Feliu, J.E.
Involvement of both phosphatidylinositol 3-kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin
Endocrinology
142
1057-1064
2001
Rattus norvegicus
Cataldi, A.; Di Pietro, R.; Centurione, L.; Grilli, A.; Cutroneo, G.; Miscia, S.
Phosphatidylinositol-3-kinase activation and atypical protein kinase C z phosphorylation characterize the DMSO signaling in erythroleukemia cells
Cell. Signal.
12
667-672
2000
Mus musculus
Chakravorty, A.; Joslyn, M.I.; Davis, J.S.
Characterization of insulin and insulin-like growth factor-I actions in the bovine luteal cell: Regulation of receptor tyrosine kinase activity, phosphatidylinositol 3-kinase, and deoxyribonucleic acid synthesis
Endocrinology
133
1331-1340
1993
Bos taurus
Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C.; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
J. Biol. Chem.
272
19236-19241
1997
Homo sapiens, Homo sapiens (O00329), Mus musculus, Mus musculus (O35940)
Dadi, H.; Ke, S.; Roifman, C.M.
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity
Blood
84
1579-1586
1994
Homo sapiens
Daniele, N.; Rajas, F.; Payrastre, B.; Mauco, G.; Zitoun, C.; Mithieux, G.
Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding
J. Biol. Chem.
274
3597-3601
1999
Rattus norvegicus
Deuter-Reinhard, M.; Apell, G.; Pot, D.; Klippel, A.; Williams, L.T.; Kavanaugh, W.M.
SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase
Mol. Cell. Biol.
17
2559-2565
1997
Xenopus sp.
Domin, J.; Pages, F.; Volinia, S.; Rittenhouse, S.E.; Zvelebil, M.J.; Stein, R.C.; Waterfield, M.D.
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
Biochem. J.
326
139-147
1997
Homo sapiens
-
Domin, J.; Dhand, R.; Waterfield, M.D.
Binding to the platelet-derived growth factor receptor transiently activates the p85a-p110a phosphoinositide 3-kinase complex in vivo
J. Biol. Chem.
271
21614-21621
1996
Mus musculus
End, P.; Gout, I.; Fry, M.J.; Panayotou, G.; Dhand, R.; Yonezawa, K.; Kasuga, M.; Waterfield, M.D.
A biosensor approach to probe the structure and function of the p85a subunit of the phosphatidylinositol 3-kinase complex
J. Biol. Chem.
268
10066-10075
1993
Bos taurus
Fujioka, T.; Ui, M.
Involvement of insulin receptor substrates in epidermal growth factor induced activation of phosphatidylinositol 3-kinase in rat hepatocyte primary culture
Eur. J. Biochem.
268
25-34
2001
Rattus norvegicus
Haefner, B.; Baxter, R.; Fincham, V.J.; Downes, C.P.; Frame, M.C.
Cooperation of Src homology domains in the regulated binding of phosphatidylinositol 3-kinase. A role for the Src homology 2 domain
J. Biol. Chem.
270
7937-7943
1995
Gallus gallus
Hardy, S.; Langelier, Y.; Prentki, M.
Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects
Cancer Res.
60
6353-6358
2000
Homo sapiens
Hauert, A.B.; Martinelli, S.; Marone, C.; Niggli, V.
Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis
Int. J. Biochem. Cell Biol.
34
838-854
2002
Homo sapiens
Herrera-Velit, P.; Reiner, N.E.
Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes
J. Immunol.
156
1157-1165
1996
Homo sapiens
Hong, Z.; Verma, D.P.S.
A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation
Proc. Natl. Acad. Sci. USA
91
9617-9621
1994
Glycine max, Glycine max (P42347), Glycine max (P42348)
Karnitz, L.M.; Sutor, S.L.; Abraham, R.T.
The Src-Family Kinase, Fyn, Regulates the Activation of Phosphatidylinositol 3-Kinase in an Interleukin 2-responsive T cell Line
J. Exp. Med.
179
1799-1808
1994
Mus musculus
Kerouz, N.J.; Horsch, D.; Pons, S.; Kahn, C.R.
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
J. Clin. Invest.
100
3164-3172
1997
Mus musculus
Kessler, A.; Uphues, I.; Ouwens, D.M.; Till, M.; Eckel, J.
Diversification of cardiac insulin signaling involves the p85a/b subunits of phosphatidylinositol 3-kinase
Am. J. Physiol.
280
E65-E74
2001
Rattus norvegicus
Khan, F.A.; Goforth, P.B.; Zhang, M.; Satin, L.S.
Insulin activates ATP-sensitive K+ channels in pancreatic b-cells through a phosphatidylinositol 3-kinase-dependent pathway
Diabetes
50
2192-2198
2001
Mus musculus
Knall, C.; Young, S.; Nick, J.A.; Buhl, A.M.; Worthen, G.S.; Johnson, G.L.
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils
J. Biol. Chem.
271
2832-2838
1996
Homo sapiens
Krymskaya, V.P.; Hoffman, R.; Eszterhas, A.; Kane, S.; Ciocca, V.; Panettieri, R.A., Jr.
EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells
Am. J. Physiol.
276
L246-L255
1999
Homo sapiens
Le Marchand-Brustel, Y.; Heydrick, S.J.; Jullien, D.; Gautier, N.; Van Obberghen, E.
Effect of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice
Metab. Clin. Exp.
44
18-23
1995
Mus musculus
Liang, J.; Chen, J.K.; Schreiber, S.L.; Clardy, J.
Crystal structure of PI3K SH3 domain at 2.0.ANG. resolution
J. Mol. Biol.
257
632-643
1996
Homo sapiens
Lu, P.J.; Hsu, A.L.; Wang, D.S.; Yan, H.Y.; Yin, H.L.; Chen, C.S.
Phosphoinositide 3-kinase in rat liver nuclei
Biochemistry
37
5738-5745
1998
Mus musculus
Marandi, S.; De Keyser, N.; Saliez, A.; Maernoudt, A.S.; Sokal, E.M.; Stilmant, C.; Rider, M.H.; Buts, J.P.
Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases
Am. J. Physiol.
280
G229-G240
2001
Rattus norvegicus
Marshall, A.J.; Krahn, A.K.; Ma, K.; Duronio, V.; Hou, S.
TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor
Mol. Cell. Biol.
22
5479-5491
2002
Homo sapiens
Mauvais-Jarvis, F.; Ueki, K.; Fruman, D.A.; Hirshman, M.F.; Sakamoto, K.; Goodyear, L.J.; Iannacone, M.; Accili, D.; Cantley, L.C.; Kahn, C.R.
Reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
J. Clin. Invest.
109
141-149
2002
Mus musculus
Minshall, C.; Arkins, S.; Freund, G.G.; Kelley, K.W.
Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
J. Immunol.
156
939-947
1996
Mus musculus
Miyakawa, Y.; Rojnuckarin, P.; Habib, T.; Kaushansky, K.
Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
J. Biol. Chem.
276
2494-2502
2001
Mus musculus
Molendijk, A.J.; Irvine, R.E.
Inositide signaling in Chlamydomonas: characterization of a phosphatidylinositol 3-kinase gene
Plant Mol. Biol.
37
53-66
1998
Chlamydomonas sp.
Molz, L.; Chen, Y.W.; Hirano, M.; Williams, L.T.
CpK is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain
J. Biol. Chem.
271
13892-13899
1996
Drosophila sp. (in: flies), Drosophila melanogaster (Q9VTN5)
Muller, G.; Wied, S.; Piossek, C.; Bauer, A.; Bauer, J.; Frick, W.
Convergence and divergence of the signaling pathways for insulin and phosphoinositolglycans
Mol. Med.
4
299-323
1998
Rattus norvegicus
Ogihara, T.; Asano, T.; Ando, K.; Chiba, Y.; Sekine, N.; Sakoda, H.; Anai, M.; Onishi, Y.; Fujishiro, M.; Ono, H.; Shojima, N.; Inukai, K.; Fukushima, Y.; Kikuchi, M.; Fujita, T.
Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats
Diabetes
50
573-583
2001
Rattus norvegicus
Okada, T.; Sakuma, L.; Fukui, Y.; Hazeki, O.; Ui, M.
Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase
J. Biol. Chem.
269
3563-3567
1994
Cavia porcellus
Okada, T.; Kawano, Y.; Sakakibara, T.; Hazeki, O.; Ui, M.
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
J. Biol. Chem.
269
3568-3573
1994
Rattus norvegicus
Pellegatta, F.; Chierchia, S.L.; Zocchi, M.R.
Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils
J. Biol. Chem.
273
27768-27771
1998
Homo sapiens
Phillips, W.A.; St.Clair, F.; Munday, A.D.; Thomas, R.J.S.; Mitchell, C.A.
Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
Cancer
83
41-47
1998
Homo sapiens
Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P.
Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor
J. Biol. Chem.
275
10093-10098
2000
Homo sapiens
Saad, M.J.A.; Folli, F.; Kahn, C.R.
Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells
Endocrinology
136
1579-1588
1995
Rattus norvegicus
Sato, M.; Bryant, H.U.; Dodge, J.A.; Davis, H.; Matter, W.F.; Vlahos, C.J.
Effects of wortmannin analogs on bone in vitro and in vivo
J. Pharmacol. Exp. Ther.
277
543-550
1996
Bos taurus, Gallus gallus, Rattus norvegicus
Stoyanov, B.; Volinia, S.; Hanck, T.; Rubio, I.; Loubtchenkov, M.; Malek, D.; Stoyanova, S.; Vanhaesebroeck, B.; Dhand, R.; et al.
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
Science
269
690-693
1995
Homo sapiens, Homo sapiens (P48736)
Tang, X.; Downes, C.P.
Purification and characterization of Gbg-responsive phosphoinositide 3-kinases from pig platelet cytosol
J. Biol. Chem.
272
14193-14199
1997
Sus scrofa
Thomson, F.J.; Moyes, C.; Scott, P.H.; Plevin, R.; Gould, G.W.
Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3'-kinase with distinct properties
Biochem. J.
316
161-166
1996
Xenopus sp.
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Tremblay, F.; Lavigne, C.; Jacques, H.; Marette, A.
Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (z/l) activities
Diabetes
50
1901-1910
2001
Rattus norvegicus
Velloso, L.A.; Carvalho, C.R.O.; Rojas, F.A.; Folli, F.; Saad, M.J.A.
Insulin signaling in heart involves insulin receptor substrates-1 and -2, activation of phosphatidylinositol 3-kinase and the JAK 2-growth related pathway
Cardiovasc. Res.
40
96-102
1998
Rattus norvegicus
Virbasius, J.V.; Guilherme, A.; Czech, M.P.
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
J. Biol. Chem.
271
13304-13307
1996
Mus musculus
Volinia, S.; Dhand, R.; Vanhaesebroeck, B.; MacDougall, L.; Stein, R.; Zvelebil, M.J.; Domin, J.; Panaretou, C.; Waterfield, M.D.
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
EMBO J.
14
3339-3348
1995
Homo sapiens
Wang, D.; Sul, H.S.
Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt
J. Biol. Chem.
273
25420-25426
1998
Mus musculus
Wang, Q.; Bilan, P.J.; Tsakiridis, T.; Hinek, A.; Klip, A.
Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
Biochem. J.
331
917-928
1998
Mus musculus
-
Wilden, P.A.; Kahn, C.R.
The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases
Mol. Endocrinol.
8
558-567
1994
Cricetulus griseus
Yang, J.; Clarke, J.F.; Ester, C.J.; Young, P.W.; Kasuga, M.; Holman, G.D.
Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
Biochem. J.
313
125-131
1996
Mus musculus
-
Yu, Y.; Sato, J.D.
MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
J. Cell. Physiol.
178
235-246
1999
Homo sapiens
Zhou, J.H.; Broussard, S.R.; Strle, K.; Freund, G.G.; Johnson, R.W.; Dantzer, R.; Kelley, K.W.
IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase
J. Immunol.
167
4436-4442
2001
Homo sapiens
Zini, N.; Ognibene, A.; Bavelloni, A.; Santi, S.; Sabatelli, P.; Baldini, N.; Scotlandi, K.; Serra, M.; Maraldi, N.M.
Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells
Histochem. Cell Biol.
106
457-464
1996
Homo sapiens
Brown, R.A.; Ho, L.K.; Weber-Hall, S.J.; Shipley, J.M.; Fry, M.J.
Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K
Biochem. Biophys. Res. Commun.
233
537-544
1997
Homo sapiens (O00750), Homo sapiens
Cafferkey, R.; Young, P.R.; McLaughlin, M.M.; Bergsma, D.J.; Koltin, Y.; Sathe, G.M.; Faucette, L.; Eng, W.K.; Johnson, R.K.; Livi, G.P.
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
Mol. Cell. Biol.
13
6012-6023
1993
Saccharomyces cerevisiae (P35169), Saccharomyces cerevisiae
Eck, R.; Bruckmann, A.; Wetzker, R.; Kunkel, W.
A phosphatidylinositol 3-kinase of Candida albicans: molecular cloning and characterization
Yeast
16
933-944
2000
Candida albicans (Q92213), Candida albicans
Helliwell, S.B.; Wagner, P.; Kunz, J.; Deuter-Reinhard, M.; Henriquez, R.; Hall, M.N.
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Homo sapiens, Mammalia
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Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
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Rattus norvegicus
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Development and characterization of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling
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Homo sapiens
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Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms
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Homo sapiens
Clarke, C.J.; Ohanian, V.; Ohanian, J.
Norepinephrine and endothelin activate diacylglycerol kinases in caveolae/rafts of rat mesenteric arteries: agonist-specific role of PI3-kinase
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Rattus norvegicus
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PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity
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Homo sapiens, Rattus norvegicus
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Mus musculus
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Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
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Mus musculus (Q3U6Q4)
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Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation
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Oryctolagus cuniculus
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Homo sapiens (Q8NEB9), Homo sapiens
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Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
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Homo sapiens
O'Connor, J.C.; Sherry, C.L.; Guest, C.B.; Freund, G.G.
Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
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Mus musculus
Tang, C.H.; Lu, D.Y.; Yang, R.S.; Tsai, H.Y.; Kao, M.C.; Fu, W.M.; Chen, Y.F.
Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia
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2007
Mus musculus
Howlett, K.F.; Sakamoto, K.; Yu, H.; Goodyear, L.J.; Hargreaves, M.
Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise
Metab. Clin. Exp.
55
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Homo sapiens
Vogt, P.K.; Kang, S.; Elsliger, M.A.; Gymnopoulos, M.
Cancer-specific mutations in phosphatidylinositol 3-kinase
Trends Biochem. Sci.
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2007
Homo sapiens
Xing, C.; Zhu, B.; Liu, H.; Yao, H.; Zhang, L.
Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901
Acta Biochim. Biophys. Sin. (Shanghai)
40
194-201
2008
Homo sapiens
von Vietinghoff, S.; Choi, M.; Rolle, S.; Luft, F.C.; Kettritz, R.
Febrile temperatures control antineutrophil cytoplasmic autoantibody-induced neutrophil activation via inhibition of phosphatidylinositol 3-kinase/Akt
Arthritis Rheum.
56
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2007
Homo sapiens
Liu, P.; Xu, B.; Li, J.; Lu, H.
LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway
Biochem. Biophys. Res. Commun.
377
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2008
Homo sapiens
Zhang, Y.; Zhang, L.; Yan, M.; Zheng, X.
Inhibition of phosphatidylinositol 3-kinase causes cell death in rat osteoblasts through inactivation of Akt
Biomed. Pharmacother.
61
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2007
Rattus norvegicus
Tamburini, J.; Chapuis, N.; Bardet, V.; Park, S.; Sujobert, P.; Willems, L.; Ifrah, N.; Dreyfus, F.; Mayeux, P.; Lacombe, C.; Bouscary, D.
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways
Blood
111
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2008
Homo sapiens
Terragni, J.; Graham, J.R.; Adams, K.W.; Schaffer, M.E.; Tullai, J.W.; Cooper, G.M.
Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors
BMC Cell Biol.
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2008
Homo sapiens
Wu, Z.L.; OKane, T.M.; Connors, T.J.; Marino, M.J.; Schaffhauser, H.
The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake
Brain Res.
1227
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2008
Rattus norvegicus
Opel, D.; Westhoff, M.A.; Bender, A.; Braun, V.; Debatin, K.M.; Fulda, S.
Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis
Cancer Res.
68
6271-6280
2008
Homo sapiens
Schnell, C.R.; Stauffer, F.; Allegrini, P.R.; OReilly, T.; McSheehy, P.M.; Dartois, C.; Stumm, M.; Cozens, R.; Littlewood-Evans, A.; Garcia-Echeverria, C.; Maira, S.M.
Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
Cancer Res.
68
6598-6607
2008
Homo sapiens
Kawaguchi, W.; Itamochi, H.; Kigawa, J.; Kanamori, Y.; Oishi, T.; Shimada, M.; Sato, S.; Shimogai, R.; Sato, S.; Terakawa, N.
Simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma
Cancer Sci.
98
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2007
Homo sapiens
Furuya, F.; Lu, C.; Willingham, M.C.; Cheng, S.Y.
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
Carcinogenesis
28
2451-2458
2007
Mus musculus
Qureshi, H.Y.; Ahmad, R.; Sylvester, J.; Zafarullah, M.
Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes
Cell. Signal.
19
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2007
Homo sapiens
Collett, G.D.; Sage, A.P.; Kirton, J.P.; Alexander, M.Y.; Gilmore, A.P.; Canfield, A.E.
Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells
Circ. Res.
100
502-509
2007
Bos taurus
Sabnis, G.; Goloubeva, O.; Jelovac, D.; Schayowitz, A.; Brodie, A.
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens
Clin. Cancer Res.
13
2751-2757
2007
Homo sapiens
Kim, J.H.; Na, H.J.; Kim, C.K.; Kim, J.Y.; Ha, K.S.; Lee, H.; Chung, H.T.; Kwon, H.J.; Kwon, Y.G.; Kim, Y.M.
The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: Role of H2O2 in NF-kappaB activation
Free Radic. Biol. Med.
45
885-896
2008
Mus musculus
Uchida, M.; Iwase, M.; Takaoka, S.; Yoshiba, S.; Kondo, G.; Watanabe, H.; Ohashi, M.; Nagumo, M.; Shintani, S.
Enhanced susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in oral squamous cell carcinoma cells treated with phosphatidylinositol 3-kinase inhibitors
Int. J. Oncol.
30
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2007
Homo sapiens
Iwase, M.; Yoshiba, S.; Uchid, M.; Takaoka, S.; Kurihara, Y.; Ito, D.; Hatori, M.; Shintani, S.
Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors
Int. J. Oncol.
31
1141-1147
2007
Homo sapiens
Pan, M.H.; Lin, C.C.; Lin, J.K.; Chen, W.J.
Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling
J. Agric. Food Chem.
55
5030-5037
2007
Homo sapiens
Tsoyi, K.; Park, H.B.; Kim, Y.M.; Chung, J.I.; Shin, S.C.; Lee, W.S.; Seo, H.G.; Lee, J.H.; Chang, K.C.; Kim, H.J.
Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway
J. Agric. Food Chem.
56
8969-8974
2008
Homo sapiens
Tzatsos, A.; Tsichlis, P.N.
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794
J. Biol. Chem.
282
18069-18082
2007
Homo sapiens
Havasi, A.; Li, Z.; Wang, Z.; Martin, J.L.; Botla, V.; Ruchalski, K.; Schwartz, J.H.; Borkan, S.C.
Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism
J. Biol. Chem.
283
12305-12313
2008
Homo sapiens
Lindemann, M.J.; Hu, Z.; Benczik, M.; Liu, K.D.; Gaffen, S.L.
Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
J. Biol. Chem.
283
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2008
Homo sapiens
Good, D.W.; George, T.; Watts, B.A.
Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
J. Biol. Chem.
283
26602-26611
2008
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Yang, P.H.; Cheung, W.K.; Peng, Y.; He, M.L.; Wu, G.Q.; Xie, D.; Jiang, B.H.; Huang, Q.H.; Chen, Z.; Lin, M.C.; Kung, H.F.
Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal
J. Biol. Chem.
283
8486-8495
2008
Xenopus sp.
Mostefai, H.A.; Agouni, A.; Carusio, N.; Mastronardi, M.L.; Heymes, C.; Henrion, D.; Andriantsitohaina, R.; Martinez, M.C.
Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells
J. Immunol.
180
5028-5035
2008
Homo sapiens
Popa-Nita, O.; Rollet-Labelle, E.; Thibault, N.; Gilbert, C.; Bourgoin, S.G.; Naccache, P.H.
Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase
J. Leukoc. Biol.
82
763-773
2007
Homo sapiens
Ren, M.; Guan, Q.; Zhong, X.; Gong, B.; Sun, Y.; Xin, W.; Guo, J.; Wang, H.; Gao, L.; Zhao, J.
Phosphatidylinositol 3-kinase/nuclear factor-kappaB signaling pathway is involved in the regulation of IGF-I on Fas-associated death domain-like interleukin-1-converting enzyme-inhibitory protein expression in cultured FRTL thyroid cells
J. Mol. Endocrinol.
38
619-625
2007
Homo sapiens
Ito, K.; Caramori, G.; Adcock, I.M.
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
J. Pharmacol. Exp. Ther.
321
1-8
2007
Homo sapiens
Lee, Y.; Huang, H.; Kim, H.J.; Park, C.K.; Kim, H.H.
The phosphatidylinositol 3-kinase-mediated production of interferon-beta is critical for the lipopolysaccharide inhibition of osteoclastogenesis
Life Sci.
83
369-376
2008
Mus musculus
Howes, A.L.; Chiang, G.G.; Lang, E.S.; Ho, C.B.; Powis, G.; Vuori, K.; Abraham, R.T.
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
Mol. Cancer Ther.
6
2505-2514
2007
Homo sapiens
Maira, S.M.; Stauffer, F.; Brueggen, J.; Furet, P.; Schnell, C.; Fritsch, C.; Brachmann, S.; Chene, P.; De Pover, A.; Schoemaker, K.; Fabbro, D.; Gabriel, D.; Simonen, M.; Murphy, L.; Finan, P.; Sellers, W.; Garcia-Echeverria, C.
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Mol. Cancer Ther.
7
1851-1863
2008
Homo sapiens
Shen, J.; Jiang, J.; Wei, Y.; Zhou, L.; Liu, D.; Zhou, J.; Gu, J.
Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis
Mol. Cell. Biochem.
304
361-367
2007
Homo sapiens
Wang, X.; Yue, P.; Chan, C.B.; Ye, K.; Ueda, T.; Watanabe-Fukunaga, R.; Fukunaga, R.; Fu, H.; Khuri, F.R.; Sun, S.Y.
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation
Mol. Cell. Biol.
27
7405-7413
2007
Homo sapiens
Lee, S.A.; Park, S.H.; Kim, B.C.
Raloxifene, a selective estrogen receptor modulator, inhibits lipopolysaccharide-induced nitric oxide production by inhibiting the phosphatidylinositol 3-kinase/Akt/nuclear factor-kappa B pathway in RAW264.7 macrophage cells
Mol. Cells
26
48-52
2008
Mus musculus
Yu, W.Z.; Zou, H.; Li, X.X.; Yan, Z.; Dong, J.Q.
Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization
Ophthalmic Res.
40
19-25
2008
Mus musculus
Gao, L.; Kwan, J.C.; Macdonald, P.S.; Yang, L.; Preiss, T.; Hicks, M.
Improved poststorage cardiac function by poly (ADP-ribose) polymerase inhibition: role of phosphatidylinositol 3-kinase Akt pathway
Transplantation
84
380-386
2007
Rattus norvegicus
Xie, P.; Williams, D.S.; Atilla-Gokcumen, G.E.; Milk, L.; Xiao, M.; Smalley, K.S.; Herlyn, M.; Meggers, E.; Marmorstein, R.
Structure-based design of an Organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity
ACS Chem. Biol.
3
305-316
2008
Homo sapiens
He, H.; Genovese, K.J.; Nisbet, D.J.; Kogut, M.H.
Phospholipase C, phosphatidylinositol 3-kinase, and intracellular [Ca(2+)] mediate the activation of chicken HD11 macrophage cells by CpG oligodeoxynucleotide
Dev. Comp. Immunol.
32
1111-1118
2008
Gallus gallus
Mitchell, C.; Kabolizadeh, P.; Ryan, J.; Roberts, J.D.; Yacoub, A.; Curiel, D.T.; Fisher, P.B.; Hagan, M.P.; Farrell, N.P.; Grant, S.; Dent, P.
Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling
Mol. Pharmacol.
72
704-714
2007
Homo sapiens
Li, X.; Xu, B.
HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway
Appl. Biochem. Biotechnol.
157
545-553
2008
Rattus norvegicus, Rattus norvegicus Wistar
Park, H.Y.; Kim, J.H.; Zuo, Z.; Do, S.H.
Ethanol increases the activity of rat excitatory amino acid transporter type 4 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase
Alcohol. Clin. Exp. Res.
32
348-354
2008
Xenopus laevis
Ding, Y.; Choi, K.J.; Kim, J.H.; Han, X.; Piao, Y.; Jeong, J.H.; Choe, W.; Kang, I.; Ha, J.; Forman, H.J.; Lee, J.; Yoon, K.S.; Kim, S.S.
Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation
Am. J. Pathol.
172
1529-1541
2008
Homo sapiens
Farre, J.C.; Mathewson, R.D.; Manjithaya, R.; Subramani, S.
Roles of Pichia pastoris Uvrag in vacuolar protein sorting and the phosphatidylinositol 3-kinase complex in phagophore elongation in autophagy pathways
Autophagy
6
86-99
2010
Komagataella pastoris
Liu, H.; Li, H.; Guo, L.; Li, M.; Li, C.; Wang, S.; Jiang, W.; Liu, X.; McNutt, M.A.; Li, G.
Mechanisms involved in phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes
Biochem. Pharmacol.
79
516-523
2010
Homo sapiens
Batra-Safferling, R.; Granzin, J.; Moedder, S.; Hoffmann, S.; Willbold, D.
Structural studies of the phosphatidylinositol 3-kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding
Biol. Chem.
391
33-42
2009
Homo sapiens
Mammadova, G.; Iwasaki, T.; Tokmakov, A.A.; Fukami, Y.; Sato, K.I.
Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization
BMC Dev. Biol.
9
68
2009
Xenopus laevis
Zhao, L.N.; Hao, L.P.; Yang, X.F.; Ying, C.J.; Yu, D.; Sun, X.F.
The diabetogenic effects of excessive ethanol: reducing beta-cell mass, decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats
Br. J. Nutr.
101
1467-1473
2009
Rattus norvegicus
Wu, J.; Ding, W.G.; Matsuura, H.; Tsuji, K.; Zang, W.J.; Horie, M.
Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel
Br. J. Pharmacol.
156
377-387
2009
Homo sapiens
Maeda, S.; Nakajima, K.; Tohyama, Y.; Kohsaka, S.
Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFbeta3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB si
Brain Res.
1305
1-13
2009
Rattus norvegicus
Sarveswaran, S.; Myers, C.E.; Ghosh, J.
MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: Synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase
Cancer Lett.
291
167-176
2009
Homo sapiens
Eichhorn, P.J.; Gili, M.; Scaltriti, M.; Serra, V.; Guzman, M.; Nijkamp, W.; Beijersbergen, R.L.; Valero, V.; Seoane, J.; Bernards, R.; Baselga, J.
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
Cancer Res.
68
9221-9230
2008
Homo sapiens
Baryawno, N.; Sveinbjoernsson, B.; Eksborg, S.; Chen, C.S.; Kogner, P.; Johnsen, J.I.
Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth
Cancer Res.
70
266-276
2010
Homo sapiens
Zhao, L.; Vogt, P.K.
Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (PI3K): Differential interactions with the regulatory subunit p85 and with RAS
Cell Cycle
9
596-600
2010
Homo sapiens
Montenegro, D.E.; Franklin, T.; Moscinski, L.C.; Zuckerman, K.S.; Hu, X.T.
TGFbeta inhibits GM-CSF-induced phosphorylation of ERK and MEK in human myeloid leukaemia cell lines via inhibition of phosphatidylinositol 3-kinase (PI3-k)
Cell Prolif.
42
1-9
2009
Homo sapiens
Hong, C.C.; Kume, T.; Peterson, R.T.
Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification
Circ. Res.
103
573-579
2008
Danio rerio
Ban, K.; Cooper, A.J.; Samuel, S.; Bhatti, A.; Patel, M.; Izumo, S.; Penninger, J.M.; Backx, P.H.; Oudit, G.Y.; Tsushima, R.G.
Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
Circ. Res.
103
643-653
2008
Mus musculus, Mus musculus C57BL/6
Fukushima, T.; Nedachi, T.; Akizawa, H.; Akahori, M.; Hakuno, F.; Takahashi, S.
Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3',5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells
Endocrinology
149
3729-3742
2008
Rattus norvegicus
Kang, M.H.; Kim, J.S.; Seo, J.E.; Oh, S.C.; Yoo, Y.A.
BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway
Exp. Cell Res.
316
24-37
2010
Homo sapiens
Rivard, N.
Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function
Front. Biosci.
14
510-522
2009
Canis lupus familiaris, Homo sapiens
Min, K.J.; Kim, J.H.; Jou, I.; Joe, E.H.
Adenosine induces hemeoxygenase-1 expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2
Glia
56
1028-1037
2008
Rattus norvegicus
Wu, J.; Wrathall, J.R.; Schachner, M.
Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes
Glia
58
315-328
2010
Mus musculus, Mus musculus C57BL/6
Son, G.; Hines, I.N.; Lindquist, J.; Schrum, L.W.; Rippe, R.A.
Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis
Hepatology
50
1512-1523
2009
Mus musculus
Kinoshita, H.; Matsuda, N.; Kaba, H.; Hatakeyama, N.; Azma, T.; Nakahata, K.; Kuroda, Y.; Tange, K.; Iranami, H.; Hatano, Y.
Roles of phosphatidylinositol 3-kinase-Akt and NADPH oxidase in adenosine 5-triphosphate-sensitive K+ channel function impaired by high glucose in the human artery
Hypertension
52
507-513
2008
Homo sapiens
Sun, X.; Zhou, H.; Luo, X.; Li, S.; Yu, D.; Hua, J.; Mu, D.; Mao, M.
Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
Int. J. Dev. Neurosci.
26
363-370
2008
Rattus norvegicus
Schoijet, A.C.; Miranda, K.; Girard-Dias, W.; de Souza, W.; Flawia, M.M.; Torres, H.N.; Docampo, R.; Alonso, G.D.
A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis
J. Biol. Chem.
283
31541-31550
2008
Trypanosoma cruzi (A9QWR8), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (A9QWR8)
Wang, J.; Rajput, A.; Kan, J.L.; Rose, R.; Liu, X.Q.; Kuropatwinski, K.; Hauser, J.; Beko, A.; Dominquez, I.; Sharratt, E.A.; Brattain, L.; Levea, C.; Sun, F.L.; Keane, D.M.; Gibson, N.W.; Brattain, M.G.
Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma
J. Biol. Chem.
284
10912-10922
2009
Homo sapiens
Scholl, S.; Bondeva, T.; Liu, Y.; Clement, J.H.; Hoeffken, K.; Wetzker, R.
Additive effects of PI3-kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of phosphatidylinositol 3-kinase gamma
J. Cancer Res. Clin. Oncol.
134
861-872
2008
Homo sapiens
Hai, J.; Lin, Q.; Lu, Y.
Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol
J. Clin. Neurosci.
16
444-448
2009
Rattus norvegicus
McLaughlin, N.J.; Banerjee, A.; Khan, S.Y.; Lieber, J.L.; Kelher, M.R.; Gamboni-Robertson, F.; Sheppard, F.R.; Moore, E.E.; Mierau, G.W.; Elzi, D.J.; Silliman, C.C.
Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils
J. Immunol.
180
8192-8203
2008
Homo sapiens
Lau, C.; Wang, X.; Song, L.; North, M.; Wiehler, S.; Proud, D.; Chow, C.W.
Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization
J. Immunol.
180
870-880
2008
Homo sapiens
Ayral-Kaloustian, S.; Gu, J.; Lucas, J.; Cinque, M.; Gaydos, C.; Zask, A.; Chaudhary, I.; Wang, J.; Di, L.; Young, M.; Ruppen, M.; Mansour, T.S.; Gibbons, J.J.; Yu, K.
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates
J. Med. Chem.
53
452-459
2009
Homo sapiens, Mus musculus
Pezet, S.; Marchand, F.; DMello, R.; Grist, J.; Clark, A.K.; Malcangio, M.; Dickenson, A.H.; Williams, R.J.; McMahon, S.B.
Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions
J. Neurosci.
28
4261-4270
2008
Rattus norvegicus
Pereira, R.I.; Leitner, J.W.; Erickson, C.; Draznin, B.
Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3-kinase
Life Sci.
83
638-643
2008
Homo sapiens, Mus musculus
Itakura, E.; Kishi, C.; Inoue, K.; Mizushima, N.
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
Mol. Biol. Cell
19
5360-5372
2008
Homo sapiens, Homo sapiens (Q6ZNE5), Homo sapiens (Q9P2Y5)
Fernandes, A.F.; Bian, Q.; Jiang, J.K.; Thomas, C.J.; Taylor, A.; Pereira, P.; Shang, F.
Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells
Mol. Biol. Cell
20
3690-3699
2009
Homo sapiens
Hu, J.; Xia, X.; Cheng, A.; Wang, G.; Luo, X.; Reed, M.F.; Fojo, T.; Oetting, A.; Gong, J.; Yen, P.M.
A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy
Mol. Cancer Ther.
7
3719-3728
2008
Homo sapiens
Ashizawa, K.; Omura, Y.; Katayama, S.; Tatemoto, H.; Narumi, K.; Tsuzuki, Y.
Intracellular signal transduction pathways in the regulation of fowl sperm motility: evidence for the involvement of phosphatidylinositol 3-kinase (PI3-K) cascade
Mol. Reprod. Dev.
76
603-610
2009
Gallus gallus
Chae, C.H.; Kim, H.T.
Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats
Neurochem. Int.
55
208-213
2009
Rattus norvegicus
Lee, Y.; Kim, E.S.; Choi, Y.; Hwang, I.; Staiger, C.J.; Chung, Y.Y.; Lee, Y.
The Arabidopsis phosphatidylinositol 3-kinase is important for pollen development
Plant Physiol.
147
1886-1897
2008
Arabidopsis thaliana (P42339)
Lee, Y.; Bak, G.; Choi, Y.; Chuang, W.I.; Cho, H.T.; Lee, Y.
Roles of phosphatidylinositol 3-kinase in root hair growth
Plant Physiol.
147
624-635
2008
Arabidopsis thaliana
Zhou, L.; Takayama, Y.; Boucher, P.; Tallquist, M.; Herz, J.
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation
PLoS ONE
4
e6922
2009
Mus musculus
Akashi, T.; Yamori, T.
Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS
Proteome Sci.
7
14
2009
Homo sapiens
Marwick, J.A.; Chung, K.F.; Adcock, I.M.
Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
Ther. Adv. Respir. Dis.
2009
1-16
2010
Homo sapiens
Chan, G.; Bivins-Smith, E.R.; Smith, M.S.; Yurochko, A.D.
NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes
Virus Res.
144
329-333
2009
Homo sapiens
Karam, M.; Lassarre, C.; Legay, C.; Ricort, J.M.
Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway
Biochim. Biophys. Acta
1823
558-569
2012
Homo sapiens
Zheng, W.; Gorre, N.; Shen, Y.; Noda, T.; Ogawa, W.; Lundin, E.; Liu, K.
Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
EMBO Rep.
11
890-895
2010
Homo sapiens (Q8NEB9)
Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
J. Biol. Chem.
285
10850-10861
2010
Homo sapiens, Mus musculus
Fukushima, T.; Nakamura, Y.; Yamanaka, D.; Shibano, T.; Chida, K.; Minami, S.; Asano, T.; Hakuno, F.; Takahashi, S.
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation
J. Biol. Chem.
287
29713-29721
2012
Rattus norvegicus
Sahu, A.; Koshinaka, K.; Sahu, M.
Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus
J. Neuroendocrinol.
25
168-179
2013
Rattus norvegicus
Liu, J.; Zhou, J.; Xing, D.
Phosphatidylinositol 3-kinase plays a vital role in regulation of rice seed vigor via altering NADPH oxidase activity
PLoS ONE
7
e33817
2012
Oryza sativa
Venkatareddy, M.; Verma, R.; Kalinowski, A.; Patel, S.R.; Shisheva, A.; Garg, P.
Distinct requirements for vacuolar protein sorting 34 downstream effector phosphatidylinositol 3-phosphate 5-kinase in podocytes versus proximal tubular cells
J. Am. Soc. Nephrol.
27
2702-2719
2016
Homo sapiens (Q8NEB9)
Mirzaa, G.M.; Conti, V.; Timms, A.E.; Smyser, C.D.; Ahmed, S.; Carter, M.; Barnett, S.; Hufnagel, R.B.; Goldstein, A.; Narumi-Kishimoto, Y.; Olds, C.; Collins, S.; Johnston, K.; Deleuze, J.F.; Nitschke, P.; Friend, K.; Harris, C.; Goetsch, A.; Martin, B.; Boyle, E.A.; Parrini, E.; Mei, D.; Tattini, L.; Slavotinek, A.; Blair, E.; Barnett, C.; Shendure, J.; Chelly, J.; Dobyns, W.B.; Guerrini, R.
Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study
Lancet Neurol.
14
1182-1195
2015
Homo sapiens (O00459), Homo sapiens
Inaguma, Y.; Ito, H.; Iwamoto, I.; Matsumoto, A.; Yamagata, T.; Tabata, H.; Nagata, K.
Morphological characterization of class III phosphoinositide 3-kinase during mouse brain development
Med. Mol. Morphol.
49
28-33
2016
Mus musculus (Q6PF93), Mus musculus
Burrows, N.; Williams, J.; Telfer, B.A.; Resch, J.; Valentine, H.R.; Fitzmaurice, R.J.; Eustace, A.; Irlam, J.; Rowling, E.J.; Hoang-Vu, C.; West, C.M.; Brabant, G.; Williams, K.J.
Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas
Oncotarget
7
63106-63123
2016
Homo sapiens
Liu, J.; Ji, Y.; Zhou, J.; Xing, D.
Phosphatidylinositol 3-kinase promotes activation and vacuolar acidification and delays methyl jasmonate-induced leaf senescence
Plant Physiol.
170
1714-1731
2016
Arabidopsis thaliana (P42339)
Backer, J.M.
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
Biochem. J.
473
2251-2271
2016
Saccharomyces cerevisiae (P22543), Mus musculus (Q6PF93), Homo sapiens (Q8NEB9)
Reidick, C.; Boutouja, F.; Platta, H.W.
The class III phosphatidylinositol 3-kinase Vps34 in Saccharomyces cerevisiae
Biol. Chem.
398
677-685
2017
Saccharomyces cerevisiae (P22543), Saccharomyces cerevisiae
Voss, O.H.; Gillespie, J.J.; Lehman, S.S.; Rennoll, S.A.; Beier-Sexton, M.; Rahman, M.S.; Azad, A.F.
Risk1, a phosphatidylinositol 3-kinase effector, promotes Rickettsia typhi intracellular survival
mBio
11
e00820-20
2020
Rickettsia typhi (Q68XM2), Rickettsia typhi, Rickettsia typhi ATCC VR-144 (Q68XM2), Rickettsia typhi Wilmington (Q68XM2)
Lee, H.N.; Jung, H.; Chung, T.
Subcellular Localization of PI3P in Arabidopsis
Methods Mol. Biol.
2177
109-118
2020
Arabidopsis thaliana (P42339)
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