2.3.1.21: carnitine O-palmitoyltransferase This is an abbreviated version! For detailed information about carnitine O-palmitoyltransferase, go to the full flat file .
Reaction
palmitoyl-CoA +
L-carnitine =
CoA +
L-palmitoylcarnitine
Synonyms acylcarnitine transferase, carnitine O-palmitoyltransferase, carnitine O-palmitoyltransferase I, carnitine palmitoyl transferase 1, carnitine palmitoyl transferase 1A, carnitine palmitoyl transferase-1A, carnitine palmitoyl transferase-I, carnitine palmitoyl-transferase-1c, carnitine palmitoyltransferae 1A, carnitine palmitoyltransferase, carnitine palmitoyltransferase 1, carnitine palmitoyltransferase 1A, carnitine palmitoyltransferase 1B, carnitine palmitoyltransferase 2, carnitine palmitoyltransferase I, carnitine palmitoyltransferase IA, carnitine palmitoyltransferase II, carnitine palmitoyltransferase-1, carnitine palmitoyltransferase-1c, carnitine palmitoyltransferase-A, carnitine palmitoyltransferase-I, carnitine palmitoyltransferases 2, CPT, CPT I, CPT IA, CPT Ialpha1a, CPT Ialpha1b, CPT Ialpha2a, CPT Ibeta, CPT II, CPT-1, CPT-2, CPT-A, CPT-B, CPT-Ialpha, CPT-IL, CPT1, CPT1-A, CPT1-B, CPT1-C, CPT1A, CPT1B, CPT1c, CPT2, CPTi, CPTI beta, CPTII, CPTo, L-carnitine palmitoyltransferase, L-CPT 1, L-CPT1, M-CPT 1, M-CPTI, muscle carnitine palmitoyltransferase I, palmitoylcarnitine transferase, palmitoyltransferase, carnitine
ECTree
Source Tissue
Source Tissue on EC 2.3.1.21 - carnitine O-palmitoyltransferase
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CPT I and CPT II
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isoforms CPT1a and CPT2 are expressed exclusively by astrocytes
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low level of expression of CPT1-C
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L-CPT I
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lowest expression
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Valanga nigricornis
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kidney cell line
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pancreatic cell line
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muscle cell line
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CPT I and CPT II
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low content of CPT II, no CPT I
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low level of expression of CPT1-C
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CPT I
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CPT1-B
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CPT1-C is predominantly expressed in
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brain-specific enzyme
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brain-specific isozyme
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brain-specific enzyme
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high level of mRNA
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low content L-CPT I and CPT II
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brain isoform CPT1a RNA and total protein expression are unchanged throughout post-natal development (PND0, PND7, PND14, PND21 and PND50). Acylcarnitines, generated by CPT1a, significantly increase with age and peak at PND21 in all brain regions, concurrent with the increased expression of enzymes involved in mitochondrial beta-oxidation
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brain isoform CPT2 RNA peaks at post-natal day 21 and remains unchanged through post-natal day 50 in all regions studied. CPT2 transcript abundance is highly developmentally regulated in the cortex, midbrain, and cerebellum, and significantly increases with age. The peak of acylcarnitine abundance in all brain regions profiled at post-natal day 21 corresponds to the maximal expression of CPT2 mRNA
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CPT II, M-CPT I
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CPT II, M-CPT I, L-CPT I
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CPT II, M-CPT I, L-CPT I
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interscapular
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M-CPT1 isozyme
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present to a significant greater extent in flight muscle than in fat body
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CPT II, M-CPT I and low content of L-CPT I
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M-CPT I
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CPT1-B
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isozyme M-CPT I
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predominant expression
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high level of mRNA
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CPT II, M-CPT I and low content of L-CPT I
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2 isoforms of CPT I
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L-CPT I
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M-CPT I
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highest activity in liver and heart
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expression of isoforms CPT1a and CPT2 increases during brain development and is enriched in hippocampus relative to the cortex, midbrain, and cerebellum
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no age differences are detected in CPT2 mRNA expression in hippocampus
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small and large, L-CPT I and CPT II
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high level of mRNA
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cortex and medulla, L-CPT I and CPT II
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L-CPT I
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CPT II
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activity is low at birth, increases by 100% during the suckling period and declines after weaning to adult levels
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CPT1A
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isozyme CPT1A
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isozyme L-CPT-1
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highest mRNA expression level
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CPT1A
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CPT1A
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high level of mRNA
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486525 , 486529 , 486535 , 486536 , 486537 , 486539 , 486541 , 486544 , 486545 , 486546 , 486547 , 486548 , 486550 , 486551 , 486552 , 486553 , 486556 , 486557 , 486559 , 486561 , 486562 , 486563 , 486564 , 486566 , 486567 , 486568 , 486569 , 486570 , 486573 , 486584 , 486586 , 657815 , 688981 , 703128 , 704114 , 736793 brenda
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L-CPT I
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M-CPT I
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CPT II
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CPT I
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isozyme L-CPT I
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isozyme L-CPT-1
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L-CPT1 isozyme
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L-CPT I
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M-CPT I
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CPT I
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highest activity in liver and heart
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low content L-CPT I and CPT II
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lactating, high level of mRNA
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non-lactating, high level of mRNA
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present to a significant greater extent in flight muscle than in fat body
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isozyme M-CPT I
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isozyme M-CPT-1
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red muscle
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red, white and heart muscle
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isozyme M-CPT I
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isozyme M-CPT-1
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white and red gastrocnemius muscles
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low level of expression of CPT1-C
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low content of M-CPT I, and higher content of CPT II ad L-CPT I
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activity continues to increase with age, reaching adult levels after 9 weeks. Concentration in adult is 10fold the apparent Km-value for carnitine
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CPT II
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CPT I
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Musculus vastus lateralis
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CPT1-B
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high level of mRNA
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M-CPT I
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CPT II
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M-CPT I
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CPT I
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intermyofibrillar and subsarcolemmal
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lowest expression
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lowest activity in muscle and spleen
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expression of CPT1-B
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low level of expression of CPT1-C
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L-CPT I and high content of CPT II and M-CPT I
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L-CPT I, not M-CPT I
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CPT II, M-CPT I
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CPT II, M-CPT I, L-CPT I
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CPT II, L-CPT I
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very low activity
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CPT II, M-CPT I, L-CPT I
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predominant expression
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lowest activity in muscle and spleen
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additional information
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ontogeny and activity in liver and muscle throughout growth and development of the domestic felid, overview
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additional information
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ubiquitous expression of CPT2
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additional information
ubiquitous expression of CPT2
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additional information
ubiquitous expression of CPT2
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additional information
Q7YQR7
no activity in spleen
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additional information
no activity in spleen
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additional information
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no activity in spleen
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additional information
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not in spleen
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additional information
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liver L-CPT I is identical with the small isoform CPT I from heart, the large isoform of CPT I from heart resembles M-CPT I from skeletal muscle
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additional information
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activity of tissue-specific isozymes L-CPT1 and M-CPT1, overview
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additional information
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ontogeny, enzyme activity, and tenzyme expression throughout growth and development, overview
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