Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxy phenylglyoxylate | CPT I, greatly reduced inhibition of protease treated enzyme | Rattus norvegicus | |
acetyl-CoA | CPT I, inhibition is not affected by proteinase treatment | Rattus norvegicus | |
carnitine | CPT I, slightly | Rattus norvegicus | |
CoA | CPT I, inhibition is not affected by proteinase treatment | Rattus norvegicus | |
Hemipalmitoylcarnitinium bromide | CPT I, strong, active-site-directed, inhibition not altered by protease treatment; i.e. HPC, 2S,6R:2R,6S-6-carboxymethyl-2-hydroxy-2-pentadecyl-4,4-dimethylmorpholinium bromide | Rattus norvegicus | |
malonyl-CoA | partial proteolysis of CPT I greatly diminishes the inhibitory effect | Rattus norvegicus | |
methylmalonyl-CoA | partial proteolysis of CPT I slightly diminishes the inhibitory effect | Rattus norvegicus | |
additional information | CPT I, 2 independent binding sites for acyl-CoA inhibitors and regulation of fatty acid oxidation, the malonyl-CoA site is located on the cytoplasmic face of the outer mitochondrial membrane, the site for monocarboxylic acids and free CoA is located in the mitochondrial intermembrane space | Rattus norvegicus | |
palmitoyl-CoA | CPT I, slightly | Rattus norvegicus | |
propionyl-CoA | CPT I, inhibition is not affected by proteinase treatment | Rattus norvegicus | |
Ro 25-0187 | CPT I, strong, inhibitory effect is drastically reduced by protease treatment of outer mitochondrial membrane; malonyl-CoA analogue | Rattus norvegicus | |
succinyl-CoA | partial proteolysis of CPT I slightly diminishes the inhibitory effect | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | CPT I | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + L-carnitine | Rattus norvegicus | CPT I, involved in regulation of fatty acid oxidation | CoA + L-acylcarnitine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
enzyme form CPT I | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine | 2 independent inhibitory sites | Rattus norvegicus | |
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine | CPT I acts at 2 distinct sites, a regulatory and an active site | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | CPT I | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.009 | - |
CPT I | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-acylcarnitine | - |
r | |
acyl-CoA + L-carnitine | CPT I, involved in regulation of fatty acid oxidation | Rattus norvegicus | CoA + L-acylcarnitine | - |
? | |
palmitoyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-palmitoylcarnitine | - |
r |