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Literature summary for 2.3.1.21 extracted from

  • Kashfi, K.; Mynatt, R.L.; Cook, G.A.
    Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation (1994), Biochim. Biophys. Acta, 1212, 245-252.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy phenylglyoxylate CPT I, greatly reduced inhibition of protease treated enzyme Rattus norvegicus
acetyl-CoA CPT I, inhibition is not affected by proteinase treatment Rattus norvegicus
carnitine CPT I, slightly Rattus norvegicus
CoA CPT I, inhibition is not affected by proteinase treatment Rattus norvegicus
Hemipalmitoylcarnitinium bromide CPT I, strong, active-site-directed, inhibition not altered by protease treatment; i.e. HPC, 2S,6R:2R,6S-6-carboxymethyl-2-hydroxy-2-pentadecyl-4,4-dimethylmorpholinium bromide Rattus norvegicus
malonyl-CoA partial proteolysis of CPT I greatly diminishes the inhibitory effect Rattus norvegicus
methylmalonyl-CoA partial proteolysis of CPT I slightly diminishes the inhibitory effect Rattus norvegicus
additional information CPT I, 2 independent binding sites for acyl-CoA inhibitors and regulation of fatty acid oxidation, the malonyl-CoA site is located on the cytoplasmic face of the outer mitochondrial membrane, the site for monocarboxylic acids and free CoA is located in the mitochondrial intermembrane space Rattus norvegicus
palmitoyl-CoA CPT I, slightly Rattus norvegicus
propionyl-CoA CPT I, inhibition is not affected by proteinase treatment Rattus norvegicus
Ro 25-0187 CPT I, strong, inhibitory effect is drastically reduced by protease treatment of outer mitochondrial membrane; malonyl-CoA analogue Rattus norvegicus
succinyl-CoA partial proteolysis of CPT I slightly diminishes the inhibitory effect Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion CPT I Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Rattus norvegicus CPT I, involved in regulation of fatty acid oxidation CoA + L-acylcarnitine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
enzyme form CPT I
-

Reaction

Reaction Comment Organism Reaction ID
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine 2 independent inhibitory sites Rattus norvegicus
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine CPT I acts at 2 distinct sites, a regulatory and an active site Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver CPT I Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.009
-
CPT I Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
Rattus norvegicus CoA + L-acylcarnitine
-
r
acyl-CoA + L-carnitine CPT I, involved in regulation of fatty acid oxidation Rattus norvegicus CoA + L-acylcarnitine
-
?
palmitoyl-CoA + L-carnitine
-
Rattus norvegicus CoA + L-palmitoylcarnitine
-
r