Reference on EC 2.3.1.21 - carnitine O-palmitoyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morillas, M.; Gomez-Puertas, P.; Roca, R.; Serra, D.; Asins, G.; Valencia, A.; Hegardt, F.G.
Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT). Mutation of CPT 1 histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity
J. Biol. Chem.
276
45001-45008
2001
Rattus norvegicus
Fiol, C.J.; Bieber, L.L.
Sigmoid kinetics of purified beef heart mitochondrial carnitine palmitoyltransferase. Effect of pH and malonyl-CoA
J. Biol. Chem.
259
13084-13088
1984
Bos taurus
Derrick, J.P.; Tubbs, P.K.; Ramsay, R.R.
Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef liver mitochondria
Biochem. Soc. Trans.
14
698
1986
Bos taurus
-
Sekas, G.; Paul, H.S.
Inhibition of carnitine acyltransferase activities by bile acids in rat liver peroxisomes
Biochim. Biophys. Acta
1125
396-402
1992
Rattus norvegicus
-
Clarke, P.R.H.; Bieber, L.L.
Isolation and purification of mitochondrial carnitine octanoyltransferase activities from beef heart
J. Biol. Chem.
256
9861-9868
1981
Bos taurus
Ramsay, R.R.
The soluble carnitine palmitoyltransferase from bovine liver. A comparison with the enzymes from peroxisomes and from the mitochondrial inner membrane
Biochem. J.
249
239-245
1988
Bos taurus
Ramsay, R.R.; Derrick, J.P.; Friend, A.S.; Tubbs, P.K.
Purification and properties of the soluble carnitine palmitoyltransferase from bovine liver mitochondria
Biochem. J.
244
271-278
1987
Bos taurus
Miyazawa, S.; Ozaka, H.; Osumi, T.; Hashiomoto, T.
Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver
J. Biochem.
94
529-542
1983
Rattus norvegicus
Fiol, C.J.; Bieber, L.L.
Effects of octylglucoside and Triton X-100 on the kinetics and specificity of carnitine palmitoyltransferase
Lipids
23
120-125
1988
Bos taurus
Lee, C.W.; Tan, C.H.
Hexokinase and carnitine palmitoyltransferase activities in flight muscles of grashopper Valanga nigricornis (Burm.)
Comp. Biochem. Physiol. B
74
791-792
1983
Valanga nigricornis
-
Brindle, N.P.J.; Zammit, V.A.; Pogson, C.I.
Inhibition of sheep liver carnitine palmitoyltransferase by methylmalonyl-CoA
Biochem. Soc. Trans.
13
880-881
1985
Ovis aries
-
Zierz, S.; Engel, A.G.
Different sites of inhibition of carnitine palmitoyltransferase by malonyl-CoA, and by acetyl-CoA and CoA, in human skeletal muscle
Biochem. J.
245
205-209
1987
Homo sapiens
Ishii, S.; Ishii, H.; Suga, T.
The presence of peroxisomal carnitine palmitoyltransferase in chick embryo liver
J. Biochem.
98
747-755
1985
Gallus gallus
Murthy, M.S.R.; Pande, S.V.
Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes
Biochem. J.
248
727-733
1987
Rattus norvegicus
Murthy, M.S.R.; Pande, S.V.
Characterization of a solubilized malonyl-CoA-sensitive carnitine palmitoyltransferase from the mitochondrial outer membrane as a protein distinct from the malonyl-CoA-insensitive carnitine palmitoyltransferase of the inner membrane
Biochem. J.
268
599-604
1990
Rattus norvegicus
Halperin, M.L.; Pande, S.V.
Fatty acyl group transport into mitochondria: carnitine palmitoyl transferases EC 2.3.1.23 and the carnitine-acylcarnitine translocase
Methods Enzymol.
56
368-378
1979
Bos taurus, Rattus norvegicus
Hoppel, C.L.
Carnitine and carnitine palmitoyltransferase in fatty acid oxidation and ketosis
Fed. Proc.
41
2853-2857
1982
Bos taurus
Kolodziej, M.P.; Zammit, V.A.
Sensitivity of inhibition of rat liver mitochondrial outer-membrane carnitine palmitoyltransferase by malonyl-CoA to chemical- and temperature-induced changes in membrane fluidity
Biochem. J.
272
421-425
1990
Rattus norvegicus
Ramsay, R.R.; Mancinelli, G.; Arduini, A.
Carnitine palmitoyltransferase in human erythrocyte membrane. Properties and malonyl-CoA sensitivity
Biochem. J.
275
685-688
1991
Homo sapiens
Woeltje, K.F.; Esser, V.; Weis, B.C.; Sen, A.; Cox, W.F.; McPaul, M.J.; Slaughter, C.A.; Foster, D.W.; McGarry, J.D.
Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II
J. Biol. Chem.
265
10720-10725
1990
Rattus norvegicus
Chung, C.H.; Woldegiorgis, G.; Dai, G.; Shrago, E.; Bieber, L.L.
Conferral of malonyl coenzyme A sensitivity to purified rat heart mitochondrial carnitine palmitoyltransferase
Biochemistry
31
9777-9783
1992
Rattus norvegicus
Kerner, J.; Bieber, L.
Isolation of a malonyl-CoA-sensitive CPT/beta-oxidation enzyme complex from heart mitochondria
Biochemistry
29
4326-4334
1990
Bos taurus
Ghadiminejad, I.; Saggerson, E.D.
Carnitine palmitoyltransferase (CPT2) from liver mitochondrial inner membrane becomes inhibitable by malonyl-CoA if reconstituted with outer membrane malonyl-CoA binding protein
FEBS Lett.
269
406-408
1990
Rattus norvegicus
Gavino, G.R.; Gavino, V.C.
Rat liver outer mitochondrial carnitine palmitoyltransferase activity towards long-chain polyunsaturated fatty acids and their CoA esters
Lipids
26
266-270
1991
Rattus norvegicus
Woldegiorgis, G.; Fibich, B.; Contreras, L.; Shrago, E.
Restoration of malonyl-CoA sensitivity of soluble rat liver mitochondria carnitine palmitoyltransferase by reconstitution with a partially purified malonyl-CoA binding protein
Arch. Biochem. Biophys.
295
348-351
1992
Rattus norvegicus
Ghadiminejad, I.; Saggerson, D.
A simple method for the purification of carnitine palmitoyl transferase 2 from rat liver
Biochem. Soc. Trans.
17
348-349
1989
Rattus norvegicus
-
Murthy, M.S.R.; Ramsay, R.R.; Pande, S.V.
Carnitine analogues and carnitine palmitoyltransferases
Biochem. Soc. Trans.
18
604-605
1990
Rattus norvegicus
Ishii, S.; Ishii, H.; Watanabe, T.; Suga, T.
Purification and properties of peroxisomal carnitine palmitoyltransferase in chick embryo liver
Biochim. Biophys. Acta
924
530-542
1987
Gallus gallus
Gandour, R.D.; Colucci, W.J.; Stelly, T.C.; Brady, P.S.; Brady, L.J.
Hemipalmitoylcarnitinium, a strong competitive inhibitor of purified hepatic carnitine palmitoyltransferase
Arch. Biochem. Biophys.
267
515-520
1988
Rattus norvegicus
Kashfi, K.; Cook, G.A.
Malonyl-CoA inhibits proteolysis of carnitine palmitoyltransferase
Biochem. Biophys. Res. Commun.
178
600-605
1991
Rattus norvegicus
Brindle, N.P.J.; Zammit, V.A.; Pogson, C.I.
Regulation of carnitine palmitoyltransferase activity by malonyl-CoA in mitochondria from sheep liver, a tissue with a low capacity for fatty acid synthesis
Biochem. J.
232
177-182
1985
Cavia porcellus, Ovis aries, Rattus norvegicus
Brady, P.S.; Dunker, A.K.; Brady, L.J.
Characterization of hepatic carnitine palmitoyltransferase. Use of bromoacyl derivatives and antibodies
Biochem. J.
241
751-757
1987
Rattus norvegicus
Bartlett, K.; Sherratt, H.S.A.; Turnbull, D.M.
Inhibition of hepatic and skeletal muscle carnitine palmitoyltransferase I by 2[5(4-chlorophenyl)pentyl]-oxirane-2-carbonyl-CoA
Biochem. Soc. Trans.
12
688-689
1984
Rattus norvegicus
-
Cook, G.A.
Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values
J. Biol. Chem.
259
12030-12033
1984
Rattus norvegicus
Brosnan, J.T.; Kopec, B.; Fritz, I.B.
The localization of carnitine palmitoyltransferase on the inner membrane of bovine liver mitochondria
J. Biol. Chem.
248
4075-4082
1973
Bos taurus, Rattus norvegicus
Paulson, D.J.; Ward, K.M.; Shug, A.L.
Malonyl CoA inhibition of carnitine palmityltransferase in rat heart mitochondria
FEBS Lett.
176
381-384
1984
Rattus norvegicus
Pande, S.V.; Murthy, M.S.R.; Noel, H.
Differential effects of phosphatidylcholine and cardiolipin on carnitine palmitoyltransferase activity
Biochim. Biophys. Acta
877
223-230
1986
Rattus norvegicus
Saggerson, E.D.; Carpenter, C.A.
Sensitivity of brown-adipose-tissue carnitine palmitoyltransferase to inhibition by malonyl-CoA
Biochem. J.
204
373-375
1982
Rattus norvegicus
Stephens, T.W.; Cook, G.A.; Harris, R.A.
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I
Biochem. J.
212
521-524
1983
Rattus norvegicus
McCormick, K.; Notar-Francesco, V.J.
Importance of albumin binding in the assay for carnitine palmitoyltransferase
Biochem. J.
216
495-498
1983
Rattus norvegicus
McCormick, K.; Notar-Francesco, V.J.; Sriwatanakul, K.
Inhibition by acetyl-CoA of hepatic carnitine acyltransferase and fatty acid oxidation
Biochem. J.
216
499-502
1983
Rattus norvegicus
Bergstrom, J.D.; Reitz, R.C.
Studies on carnitine palmitoyl transferase: the similar nature of CPTi (inner form) and CPTo (outer form)
Arch. Biochem. Biophys.
204
71-79
1980
Rattus norvegicus
Finocchiaro, G.; Colombo, I.; DiDonato, S.
Purification, characterization and partial amino acid sequences of carnitine palmitoyl-transferase from human liver
FEBS Lett.
274
163-166
1990
Homo sapiens
Declercq, P.E.; Falck, J.R.; Kuwajima, M.; Tyminski, H.; Foster, D.W.; McGarry, J.D.
Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors
J. Biol. Chem.
262
9812-9821
1987
Rattus norvegicus
Woeltje, K.F.; Esser, V.; Weis, B.C.; Cox, W.F.; Schroeder, J.G.; Liao, S.L.; Foster, D.W.; McGarry, J.D.
Inter-tissue and inter-species characteristics of the mitochondrial carnitine palmitoyltransferase enzyme system
J. Biol. Chem.
265
10714-10719
1990
Homo sapiens, Platyrrhini, Mus musculus, Rattus norvegicus
Lund, H.
Carnitine palmitoyltransferase: characterization of a labile detergent-extracted malonyl-CoA-sensitive enzyme from rat liver mitochondria
Biochim. Biophys. Acta
918
67-75
1987
Rattus norvegicus
Kopec, B.; Fritz, I.B.
Comparison of properties of carnitine palmitoyltransferase I with those of carnitine palmitoyltransferase II, and preparation of antibodies to carnitine palmitoyltransferases
J. Biol. Chem.
248
4069-4074
1973
Rattus norvegicus
Woldegiorgis, G.; Bremer, J.; Shrago, E.
Substrate inhibition of carnitine palmitoyltransferase by palmitoyl-CoA and activation by phospholipids and proteins
Biochim. Biophys. Acta
837
135-140
1985
Rattus norvegicus
Weis, B.C.; Cowan, A.T.; Brown, N.; Foster, D.W.; McGarry, J.D.
Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme
J. Biol. Chem.
269
26443-26448
1994
Rattus norvegicus
Kashfi, K.; Mynatt, R.L.; Cook, G.A.
Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation
Biochim. Biophys. Acta
1212
245-252
1994
Rattus norvegicus
Singh, H.; Poulos, A.
Substrate specificity of rat liver mitochondrial carnitine palmitoyl transferase I: evidence against alpha-oxidation of phytanic acid in rat liver mitochondria
FEBS Lett.
359
179-183
1995
Rattus norvegicus
Johnson, T.M.; Mann, W.R.; Dragland, C.J.; Anderson, R.C.; Nemecek, G.M.; Bell, P.A.
Over-expression and characterization of active recombinant rat liver carnitine palmitoyltransferase II using baculovirus
Biochem. J.
309
689-693
1995
Rattus norvegicus
-
Zhu, H.; Shi, J.; Cregg, J.M.; Woldegiorgis, G.
Reconstitution of highly expressed human heart muscle carnitine palmitoyltransferase I
Biochem. Biophys. Res. Commun.
239
498-502
1997
Homo sapiens
De Vries, Y.; Arvidson, D.N.; Waterham, H.R.; Cregg, J.M.; Woldegiorgis, G.
Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris
Biochemistry
36
5285-5292
1997
no activity in Pichia pastoris, Rattus norvegicus
Brown, N.F.; Hill, J.K.; Esser, V.; Kirkland, J.L.; Corkey, B.E.; Foster, D.W.; McGarry, J.D.
Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes
Biochem. J.
327
225-231
1997
Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
-
Schmidt, I.; Herpin, P.
Carnitine palmitoyltransferase I (CPT I) activity and its regulation by malonyl-CoA are modulated by age and cold exposure in skeletal muscle mitochondria from newborn pigs
J. Nutr.
128
886-893
1998
Sus scrofa
Nic a'Bhaird, N.; Yankovskaya, V.; Ramsay, R.R.
Active sites residues of beef liver carnitine octanoyltransferase (COT) and carnitine palmitoyltransferase (CPT-II)
Biochem. J.
330
1029-1036
1998
Bos taurus
-
Prip-Buus, C.; Cohen, I.; Kohl, C.; Esser, V.; McGarry, J.D.; Girard, J.
Topological and functional analysis of the rat liver carnitine palmitoyltransferase 1 expressed in Saccharomyces cerevisiae
FEBS Lett.
429
173-178
1998
Rattus norvegicus
Hertel, K.; Gellerich, F.N.; Hein, W.; Zierz, S.
Kinetic investigation of carnitine palmitoyltransferases in homogenates of human skeletal muscle using L-amino-carnitine and malonyl-CoA
Adv. Exp. Med. Biol.
466
87-93
1999
Homo sapiens
Jackson, V.N.; Cameron, J.M.; Fraser, F.; Zammit, V.A.; Price, N.T.
Use of six chimeric proteins to investigate the role of intramolecular interactions in determining the kinetics of carnitine palmitoyltransferase I isoforms
J. Biol. Chem.
275
19560-19566
2000
Rattus norvegicus
Masterson, C.; Wood, C.
Carnitine palmitoyltransferases in pea leaf chloroplasts: partial purification, location, and properties
Can. J. Bot.
78
328-335
2000
Pisum sativum
Eaton, S.; Fukumoto, K.; Paladio Duran, N.; Pierro, A.; Spitz, L.; Quant, P.A.; Bartlett, K.
Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux
Biochem. Soc. Trans.
29
245-250
2001
Homo sapiens, Rattus norvegicus
Nicot, C.; Hegardt, F.G.; Woldegiorgis, G.; Haro, D.; Marrero, P.F.
Pig liver carnitine palmitoyltransferase I, with low Km for carnitine and high sensitivity to malonyl-CoA inhibition, is a natural chimera of rat liver and muscle enzymes
Biochemistry
40
2260-2266
2001
Sus scrofa
Abo-Hashema, K.A.H.; Cake, M.H.; Lukas, M.A.; Knudsen, J.
The interaction of acyl-CoA with acyl-CoA binding protein and carnitine palmitoyltransferase I
Int. J. Biochem. Cell Biol.
33
807-815
2001
Rattus norvegicus
Haap, M.; Thamer, C.; Machann, J.; Tschritter, O.; Loblein, K.; Kellerer, M.; Schick, F.; Jacob, S.; Haring, H.U.; Stumvoll, M.
Metabolic characterization of a woman homozygous for the Ser113Leu missense mutation in carnitine palmitoyl transferase II
J. Clin. Endocrinol. Metab.
87
2139-2143
2002
Homo sapiens
Colquhoun, A.
Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour
Biochim. Biophys. Acta
1583
74-84
2002
Rattus norvegicus
Nicot, C.; Relat, J.; Woldegiorgis, G.; Haro, D.; Marrero, P.F.
Pig liver carnitine palmitoyltransferase: chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity
J. Biol. Chem.
277
10044-10049
2002
Rattus norvegicus, Sus scrofa
McGarry, J.D.; Brown, N.F.
Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity
Biochem. J.
349
179-187
2000
Rattus norvegicus
Bieber, L.L.; Fiol, C.
Purification and assay of carnitine acyltransferases
Methods Enzymol.
123
276-284
1986
Bos taurus
Zhu, H.; Shi, J.; Treber, M.; Dai, J.; Arvidson, D.N.; Woldegiorgis, G.
Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding
Arch. Biochem. Biophys.
413
67-74
2003
Homo sapiens
Dai, J.; Zhu, H.; Woldegiorgis, G.
Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity
Biochem. Biophys. Res. Commun.
301
758-763
2003
Homo sapiens (Q92523)
Broadway, N.M.; Pease, R.J.; Birdsey, G.; Shayeghi, M.; Turner, N.A.; David Saggerson, E.
The liver isoform of carnitine palmitoyltransferase 1 is not targeted to the endoplasmic reticulum
Biochem. J.
370
223-231
2003
Rattus norvegicus
Price, N.T.; Jackson, V.N.; van der Leij, F.R.; Cameron, J.M.; Travers, M.T.; Bartelds, B.; Huijkman, N.C.; Zammit, V.A.
Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme
Biochem. J.
372
871-879
2003
Ovis aries (Q7YQR7), Ovis aries (Q8SPI7), Ovis aries
Relat, J.; Nicot, C.; Gacias, M.; Woldegiorgis, G.; Marrero, P.F.; Haro, D.
Pig muscle carnitine palmitoyltransferase I (CPTI beta), with low Km for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTI alpha) enzyme
Biochemistry
43
12686-12691
2004
Sus scrofa (Q5US13), Sus scrofa
Napal, L.; Dai, J.; Treber, M.; Haro, D.; Marrero, P.F.; Woldegiorgis, G.
A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme
J. Biol. Chem.
278
34084-34089
2003
Rattus norvegicus (P32198)
Morillas, M.; Gomez-Puertas, P.; Bentebibel, A.; Selles, E.; Casals, N.; Valencia, A.; Hegardt, F.G.; Asins, G.; Serra, D.
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition
J. Biol. Chem.
278
9058-9063
2003
Rattus norvegicus (P32198)
Kerner, J.; Distler, A.M.; Minkler, P.; Parland, W.; Peterman, S.M.; Hoppel, C.L.
Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme
J. Biol. Chem.
279
41104-41113
2004
Rattus norvegicus (P32198)
Lin, X.; Odle, J.
Changes in kinetics of carnitine palmitoyltransferase in liver and skeletal muscle of dogs (Canis familiaris) throughout growth and development
J. Nutr.
133
1113-1119
2003
Canis lupus familiaris
Bonnefont, J.P.; Djouadi, F.; Prip-Buus, C.; Gobin, S.; Munnich, A.; Bastin, J.
Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects
Mol. Aspects Med.
25
495-520
2004
Homo sapiens, Homo sapiens (P23786), Homo sapiens (P50416)
Bruce, C.R.; Brolin, C.; Turner, N.; Cleasby, M.E.; van der Leij, F.R.; Cooney, G.J.; Kraegen, E.W.
Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification
Am. J. Physiol. Endocrinol. Metab.
292
E1231-E1237
2007
Homo sapiens
Bentebibel, A.; Sebastian, D.; Herrero, L.; Lopez-Vinas, E.; Serra, D.; Asins, G.; Gomez-Puertas, P.; Hegardt, F.G.
Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation
Biochemistry
45
4339-4350
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Tamaoki, Y.; Kimura, M.; Hasegawa, Y.; Iga, M.; Inoue, M.; Yamaguchi, S.
A survey of Japanese patients with mitochondrial fatty acid beta-oxidation and related disorders as detected from 1985 to 2000
Brain Dev.
24
675-680
2002
Homo sapiens
Kuhajda, F.P.; Ronnett, G.V.
Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity
Curr. Opin. Investig. Drugs
8
312-317
2007
Homo sapiens, Rattus norvegicus
Shin, E.S.; Cho, S.Y.; Lee, E.H.; Lee, S.J.; Chang, I.S.; Lee, T.R.
Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine
Eur. J. Nutr.
45
159-164
2006
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Liu, H.; Zheng, G.; Treber, M.; Dai, J.; Woldegiorgis, G.
Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis
J. Biol. Chem.
280
4524-4531
2005
Homo sapiens
Lopez-Vinas, E.; Bentebibel, A.; Gurunathan, C.; Morillas, M.; de Arriaga, D.; Serra, D.; Asins, G.; Hegardt, F.G.; Gomez-Puertas, P.
Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A
J. Biol. Chem.
282
18212-18224
2007
Homo sapiens
Lyvers Peffer, P.; Lin, X.; Jacobi, S.K.; Gatlin, L.A.; Woodworth, J.; Odle, J.
Ontogeny of carnitine palmitoyltransferase I activity, carnitine-Km, and mRNA abundance in pigs throughout growth and development
J. Nutr.
137
898-903
2007
Sus scrofa
Lin, X.; House, R.; Odle, J.
Ontogeny and kinetics of carnitine palmitoyltransferase in liver and skeletal muscle of the domestic felid (Felis domestica)
J. Nutr. Biochem.
16
331-338
2005
Felis catus
Doh, K.O.; Kim, Y.W.; Park, S.Y.; Lee, S.K.; Park, J.S.; Kim, J.Y.
Interrelation between long-chain fatty acid oxidation rate and carnitine palmitoyltransferase 1 activity with different isoforms in rat tissues
Life Sci.
77
435-443
2005
Rattus norvegicus
Ratheiser, K.; Schneeweiss, B.; Waldhaeusl, W.; Fasching, P.; Korn, A
Nowotny, P.; Rohac, M.; Wolf, H.P.O.: Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus
Metabolism
40
1185-1190
1991
Homo sapiens
Wolfgang, M.J.; Kurama, T.; Dai, Y.; Suwa, A.; Asaumi, M.; Matsumoto, S.; Cha, S.H.; Shimokawa, T.; Lane, M.D.
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
Proc. Natl. Acad. Sci. USA
103
7282-7287
2006
Mus musculus
Stefanovic-Racic, M.; Perdomo, G.; Mantell, B.S.; Sipula, I.J.; Brown, N.F.; ODoherty, R.M.
A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels
Am. J. Physiol. Endocrinol. Metab.
294
E969-E977
2008
Rattus norvegicus (P18886), Rattus norvegicus (P32198)
Aoi, W.; Naito, Y.; Takanami, Y.; Ishii, T.; Kawai, Y.; Akagiri, S.; Kato, Y.; Osawa, T.; Yoshikawa, T.
Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification
Biochem. Biophys. Res. Commun.
366
892-897
2008
Mus musculus (Q924X2)
Morash, A.J.; Kajimura, M.; McClelland, G.B.
Intertissue regulation of carnitine palmitoyltransferase I (CPTI): mitochondrial membrane properties and gene expression in rainbow trout (Oncorhynchus mykiss)
Biochim. Biophys. Acta
1778
1382-1389
2008
Oncorhynchus mykiss
Sorokina, N.; ODonnell, J.M.; McKinney, R.D.; Pound, K.M.; Woldegiorgis, G.; LaNoue, K.F.; Ballal, K.; Taegtmeyer, H.; Buttrick, P.M.; Lewandowski, E.D.
Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts
Circulation
115
2033-2041
2007
Rattus norvegicus
Okere, I.C.; Chandler, M.P.; McElfresh, T.A.; Rennison, J.H.; Kung, T.A.; Hoit, B.D.; Ernsberger, P.; Young, M.E.; Stanley, W.C.
Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet
Clin. Exp. Pharmacol. Physiol.
34
113-119
2007
Rattus norvegicus
Sierra, A.Y.; Gratacos, E.; Carrasco, P.; Clotet, J.; Urena, J.; Serra, D.; Asins, G.; Hegardt, F.G.; Casals, N.
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity
J. Biol. Chem.
283
6878-6885
2008
Rattus norvegicus
Kuroda, T.; Hirota, H.; Fujio, Y.; Sugiyama, S.; Masaki, M.; Hiramoto, Y.; Shioyama, W.; Okamoto, K.; Hori, M.; Yamauchi-Takihara, K.
Carbacyclin induces carnitine palmitoyltransferase-1 in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) delta independent of the IP receptor signaling pathway
J. Mol. Cell. Cardiol.
43
54-62
2007
Mus musculus, Rattus norvegicus
Sadana, P.; Zhang, Y.; Song, S.; Cook, G.A.; Elam, M.B.; Park, E.A.
Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms
Mol. Cell. Endocrinol.
267
6-16
2007
Rattus norvegicus
Yamazaki, N.; Matsuo, T.; Kurata, M.; Suzuki, M.; Fujiwaki, T.; Yamaguchi, S.; Terada, H.; Shinohara, Y.
Substitutions of three amino acids in human heart/muscle type carnitine palmitoyltransferase I caused by single nucleotide polymorphisms
Biochem. Genet.
46
54-63
2008
Homo sapiens
Matsuo, T.; Yamamoto, A.; Yamamoto, T.; Otsuki, K.; Yamazaki, N.; Kataoka, M.; Terada, H.; Shinohara, Y.
Replacement of C305 in Heart/Muscle-Type Isozyme of Human Carnitine Palmitoyltransferase I with Aspartic Acid and Other Amino Acids
Biochem. Genet.
48
193-201
2010
Homo sapiens
Akkaoui, M.; Cohen, I.; Esnous, C.; Lenoir, V.; Sournac, M.; Girard, J.; Prip-Buus, C.
Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids
Biochem. J.
420
429-438
2009
Rattus norvegicus
Rufer, A.C.; Thoma, R.; Hennig, M.
Structural insight into function and regulation of carnitine palmitoyltransferase
Cell. Mol. Life Sci.
66
2489-2501
2009
Rattus norvegicus
Lavarias, S.; Pasquevich, M.Y.; Dreon, M.S.; Heras, H.
Partial characterization of a malonyl-CoA-sensitive carnitine O-palmitoyltransferase I from Macrobrachium borellii (Crustacea: Palaemonidae)
Comp. Biochem. Physiol. B
152
364-369
2009
Macrobrachium borellii
Morash, A.J.; Bureau, D.P.; McClelland, G.B.
Effects of dietary fatty acid composition on the regulation of carnitine palmitoyltransferase (CPT) I in rainbow trout (Oncorhynchus mykiss)
Comp. Biochem. Physiol. B
152
85-93
2009
Oncorhynchus mykiss
Bruce, C.R.; Hoy, A.J.; Turner, N.; Watt, M.J.; Allen, T.L.; Carpenter, K.; Cooney, G.J.; Febbraio, M.A.; Kraegen, E.W.
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance
Diabetes
58
550-558
2009
Homo sapiens (Q92523)
Relat, J.; Pujol-Vidal, M.; Haro, D.; Marrero, P.F.
A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme
FEBS J.
276
210-218
2009
Homo sapiens, Sus scrofa
Yao, D.; Mizuguchi, H.; Yamaguchi, M.; Yamada, H.; Chida, J.; Shikata, K.; Kido, H.
Thermal instability of compound variants of carnitine palmitoyltransferase II and impaired mitochondrial fuel utilization in influenza-associated encephalopathy
Hum. Mutat.
29
718-727
2008
Homo sapiens (P23786), Homo sapiens
Roomets, E.; Kivelae, T.; Tyni, T.
Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in retina: insights of retinopathy in mitochondrial trifunctional protein defects
Invest. Ophthalmol. Vis. Sci.
49
1660-1664
2008
Homo sapiens, Rattus norvegicus
Zammit, V.
Carnitine palmitoyltransferase 1: central to cell function
IUBMB Life
60
347-354
2008
Rattus norvegicus
Price, N.T.; Jackson, V.N.; Muller, J.; Moffat, K.; Borthwick, K.L.; Orton, T.; Zammit, V.A.
Alternative exon usage in the single carnitine palmitoyltransferase 1 (CPT 1) gene of drosophila generates functional diversity in the kinetic properties of the enzyme. Differential expression of alternatively spliced variants in drosophila tissues
J. Biol. Chem.
285
7857-7865
2010
Drosophila melanogaster
Wolfgang, M.J.; Cha, S.H.; Millington, D.S.; Cline, G.; Shulman, G.I.; Suwa, A.; Asaumi, M.; Kurama, T.; Shimokawa, T.; Lane, M.D.
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight
J. Neurochem.
105
1550-1559
2008
Mus musculus
Xi, L.; Brown, K.; Woodworth, J.; Shim, K.; Johnson, B.; Odle, J.
Maternal dietary L-carnitine supplementation influences fetal carnitine status and stimulates carnitine palmitoyltransferase and pyruvate dehydrogenase complex activities in swine
J. Nutr.
138
2356-2362
2008
Sus scrofa
Bi, Y.; Cai, M.; Liang, H.; Sun, W.; Li, X.; Wang, C.; Zhu, Y.; Chen, X.; Li, M.; Weng, J.
Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-indu
Metab. Clin. Exp.
58
779-786
2009
Rattus norvegicus
Sharma, V.; Abraham, T.; So, A.; Allard, M.; McNeill, J.
Functional effects of protein kinases and peroxynitrite on cardiac carnitine palmitoyltransferase-1 in isolated mitochondria
Mol. Cell. Biochem.
337
223-237
2010
Rattus norvegicus
Greenberg, C.R.; Dilling, L.A.; Thompson, G.R.; Seargeant, L.E.; Haworth, J.C.; Phillips, S.; Chan, A.; Vallance, H.D.; Waters, P.J.; Sinclair, G.; Lillquist, Y.; Wanders, R.J.; Olpin, S.E.
The paradox of the carnitine palmitoyltransferase type Ia P479L variant in Canadian Aboriginal populations
Mol. Genet. Metab.
96
201-207
2009
Homo sapiens
Lin, X.; Shim, K.; Odle, J.
Carnitine palmitoyltransferase I control of acetogenesis, the major pathway of fatty acid {beta}-oxidation in liver of neonatal swine
Am. J. Physiol. Regul. Integr. Comp. Physiol.
298
R1435-R1443
2010
Sus scrofa
Violante, S.; Ijlst, L.; van Lenthe, H.; de Almeida, I.T.; Wanders, R.J.; Ventura, F.V.
Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling
Biochim. Biophys. Acta
1802
728-732
2010
Homo sapiens (P23786), Homo sapiens
Zaugg, K.; Yao, Y.; Reilly, P.T.; Kannan, K.; Kiarash, R.; Mason, J.; Huang, P.; Sawyer, S.K.; Fuerth, B.; Faubert, B.; Kalliomaeki, T.; Elia, A.; Luo, X.; Nadeem, V.; Bungard, D.; Yalavarthi, S.; Growney, J.D.; Wakeham, A.; Moolani, Y.; Silvester, J.; Ten, A.Y.; Bakker, W.; Tsuchihara, K.; Berger, S.L.; H, H.i.
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
Genes Dev.
25
1041-1051
2011
Mus musculus (Q8BGD5), Mus musculus, Homo sapiens (Q8TCG5), Homo sapiens
Lee, K.; Kerner, J.; Hoppel, C.L.
Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex
J. Biol. Chem.
286
25655-25662
2011
Rattus norvegicus (P32198)
Price, E.R.; Staples, J.F.; Milligan, C.L.; Guglielmo, C.G.
Carnitine palmitoyl transferase activity and whole muscle oxidation rates vary with fatty acid substrate in avian flight muscles
J. Comp. Physiol. B
181
565-573
2011
Zonotrichia albicollis
Hostetler, H.A.; Lupas, D.; Tan, Y.; Dai, J.; Kelzer, M.S.; Martin, G.G.; Woldegiorgis, G.; Kier, A.B.; Schroeder, F.
Acyl-CoA binding proteins interact with the acyl-CoA binding domain of mitochondrial carnitine palmitoyl transferase I
Mol. Cell. Biochem.
355
135-148
2011
Rattus norvegicus (P32198)
Hada, T.; Kato, Y.; Obana, E.; Yamamoto, A.; Yamazaki, N.; Hashimoto, M.; Yamamoto, T.; Shinohara, Y.
Comparison of two expression systems using COS7 cells and yeast cells for expression of heart/muscle-type carnitine palmitoyltransferase 1
Protein Expr. Purif.
82
192-196
2012
Rattus norvegicus (Q63704)
Hada, T.; Yamamoto, T.; Yamamoto, A.; Ohkura, K.; Yamazaki, N.; Takiguchi, Y.; Shinohara, Y.
Comparison of the catalytic activities of three isozymes of carnitine palmitoyltransferase 1 expressed in COS7 cells
Appl. Biochem. Biotechnol.
172
1486-1496
2014
Rattus norvegicus
Violante, S.; Ijlst, L.; Ruiter, J.; Koster, J.; van Lenthe, H.; Duran, M.; de Almeida, I.T.; Wanders, R.J.; Houten, S.M.; Ventura, F.V.
Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid and branched-chain amino acid metabolism
Biochim. Biophys. Acta
1832
773-779
2013
Homo sapiens (P23786), Homo sapiens
Lu, K.L.; Zhang, D.D.; Wang, L.N.; Xu, W.N.; Liu, W.B.
Molecular characterization of carnitine palmitoyltransferase IA in Megalobrama amblycephala and effects on its expression of feeding status and dietary lipid and berberine
Comp. Biochem. Physiol. B
191
20-25
2016
Megalobrama amblycephala (A0A0A7ECG5), Megalobrama amblycephala
Violante, S.; Ijlst, L.; Te Brinke, H.; Tavares de Almeida, I.; Wanders, R.J.; Ventura, F.V.; Houten, S.M.
Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines
FASEB J.
27
2039-2044
2013
Homo sapiens (P23786), Homo sapiens
Hu, W.; Luo, Z.; Mai, K.S.; Liu, C.X.; Zheng, J.L.
Ontogeny and kinetics of carnitine palmitoyltransferase I in hepatopancreas and skeletal muscle of grass carp (Ctenopharyngodon idella)
Fish Physiol. Biochem.
41
1393-1401
2015
Ctenopharyngodon idella
Setoyama, D.; Fujimura, Y.; Miura, D.
Metabolomics reveals that carnitine palmitoyltransferase-1 is a novel target for oxidative inactivation in human cells
Genes Cells
18
1107-1119
2013
Homo sapiens
Zheng, J.; Luo, Z.; Zhu, Q.; Chen, Q.; Gong, Y.
Molecular characterization, Tissue distribution and kinetic analysis of carnitine palmitoyltransferase I in juvenile yellow catfish Pelteobagrus fulvidraco
Genomics
101
195-203
2013
Tachysurus fulvidraco (M4H3I4), Tachysurus fulvidraco (M4H3S7), Tachysurus fulvidraco (M4H428), Tachysurus fulvidraco (M4H4E4), Tachysurus fulvidraco
Liu, C.X.; Luo, Z.; Hu, W.; Tan, X.Y.; Zheng, J.L.; Chen, Q.L.; Zhu, Q.L.
Kinetics of carnitine palmitoyltransferase I (CPT I) in Chinese sucker (Myxocyprinus asiaticus) change with its development
Lipids
49
173-181
2014
Myxocyprinus asiaticus
Console, L.; Giangregorio, N.; Indiveri, C.; Tonazzi, A.
Carnitine/acylcarnitine translocase and carnitine palmitoyltransferase 2 form a complex in the inner mitochondrial membrane
Mol. Cell. Biochem.
394
307-314
2014
Rattus norvegicus
Pucci, S.; Zonetti, M.J.; Fisco, T.; Polidoro, C.; Bocchinfuso, G.; Palleschi, A.; Novelli, G.; Spagnoli, L.G.; Mazzarelli, P.
Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer
Oncotarget
12
19982-19996
2016
Homo sapiens (P50416), Homo sapiens
Yao, M.; Cai, M.; Yao, D.; Xu, X.; Yang, R.; Li, Y.; Zhang, Y.; Kido, H.; Yao, D.
Abbreviated half-lives and impaired fuel utilization in carnitine palmitoyltransferase II variant fibroblasts
PLoS ONE
10
e0119936
2015
Homo sapiens (P23786), Homo sapiens
Wang, C.C.; Si, L.F.; Li, W.Y.; Zheng, J.L.
A functional gene encoding carnitine palmitoyltransferase 1 and its transcriptional and kinetic regulation during fasting in large yellow croaker
Comp. Biochem. Physiol. B
231
26-33
2019
Larimichthys crocea (A0A0F8C7P8), Larimichthys crocea
Menezes dos Reis, L.; Adamoski, D.; Ornitz Oliveira Souza, R.; Rodrigues Ascencao, C.F.; Sousa de Oliveira, K.R.; Correa-da-Silva, F.; Malta de Sa Patroni, F.; Meira Dias, M.; Consonni, S.R.; Mendes de Moraes-Vieira, P.M.; Silber, A.M.; Dias, S.M.G.
Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells
J. Biol. Chem.
294
9342-9357
2019
Homo sapiens, Homo sapiens (P23786)
Guan, L.; Chen, Y.; Wang, Y.; Zhang, H.; Fan, S.; Gao, Y.; Jiao, T.; Fu, K.; Sun, J.; Yu, A.; Huang, M.; Bi, H.
Effects of carnitine palmitoyltransferases on cancer cellular senescence
J. Cell. Physiol.
234
1707-1719
2019
Homo sapiens (P23786), Homo sapiens (Q8TCG5), Homo sapiens (Q92523)
Jernberg, J.N.; Bowman, C.E.; Wolfgang, M.J.; Scafidi, S.
Developmental regulation and localization of carnitine palmitoyltransferases (CPTs) in rat brain
J. Neurochem.
142
407-419
2017
Rattus norvegicus (P18886), Rattus norvegicus (P32198)
Motlagh, L.; Golbik, R.; Sippl, W.; Zierz, S.
Stabilization of the thermolabile variant S113L of carnitine palmitoyltransferase II
Neurol. Genet.
2
e53
2016
Homo sapiens (P23786)
Lee, J.; Hyon, J.; Min, J.; Huh, Y.; Kim, H.; Lee, H.; Yun, S.; Choi, C.; Jeong Ha, S.; Park, J.; Chung, Y.; Jeong, H.; Ha, S.; Jung, S.; Kim, Y.; Han, E.
Mitochondrial carnitine palmitoyltransferase 2 is involved in Nepsilon-(carboxymethyl)-lysine-mediated diabetic nephropathy
Pharmacol. Res.
152
104600
2020
Homo sapiens (P23786), Homo sapiens
Yao, C.H.; Liu, G.Y.; Wang, R.; Moon, S.H.; Gross, R.W.; Patti, G.J.
Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of beta-oxidation
PLoS Biol.
16
e2003782
2018
Homo sapiens (P50416)
Calderon-Dominguez, M.; Sebastian, D.; Fucho, R.; Weber, M.; Mir, J.F.; Garcia-Casarrubios, E.; Obregon, M.J.; Zorzano, A.; Valverde, A.M.; Serra, D.; Herrero, L.
Carnitine palmitoyltransferase 1 increases lipolysis, UCP1 protein expression and mitochondrial activity in brown adipocytes
PLoS ONE
11
e0159399
2016
Homo sapiens (P50416), Homo sapiens
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