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Literature summary for 2.3.1.21 extracted from
- Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms (2007), Mol. Cell. Endocrinol., 267, 6-16.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| liothyronine | - |
Rattus norvegicus |  |
| PGC-1beta | peroxisome proliferator activated receptor gamma coactivator | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| a rat promoter CPT-Ialpha luciferase vector is constructed | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| malonyl-CoA | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| palmitoyl-CoA + L-carnitine | Rattus norvegicus | - |
CoA + L-palmitoylcarnitine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0021 | - |
rat primary hepatocytes infected with adenovirus vectors expressing Ad-GFP | Rattus norvegicus |
| 0.0036 | - |
rat primary hepatocytes infected with adenovirus vectors expressing Ad-PGC-1beta | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| palmitoyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-palmitoylcarnitine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carnitine palmitoyltransferase I | - |
Rattus norvegicus |
| CPT-Ialpha | liver isoform | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
activity assay | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
activity assay | Rattus norvegicus |
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Release 2023.1 (January 2023)
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