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Literature summary for 2.3.1.21 extracted from

  • Relat, J.; Nicot, C.; Gacias, M.; Woldegiorgis, G.; Marrero, P.F.; Haro, D.
    Pig muscle carnitine palmitoyltransferase I (CPTI beta), with low Km for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTI alpha) enzyme (2004), Biochemistry, 43, 12686-12691.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
CPTI beta is expressed in Pichia pastoris Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA IC50: 906 nM Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.083
-
 palmitoyl-CoA pH 7.0, recombinant enzyme Sus scrofa
0.197
-
 L-carnitine pH 7.0, recombinant enzyme Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa Q5US13
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-carnitine
-
 Sus scrofa CoA + L-palmitoylcarnitine
-
 ?

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase I
-
 Sus scrofa
CPTI beta
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000906
-
 IC50: 906 nM Sus scrofa malonyl-CoA