Cloned (Comment) | Organism |
---|---|
expression of His-tagged L-CPT I in Pichia pastoris | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
malonyl-CoA | CPT I; membrane or micelle composition and properties influence the sensitivity of CPT I to inhibition; regulatory role in vivo | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.028 | - |
palmitoyl-CoA | purified recombinant L-CPT I, reconstituted in liposomes | Rattus norvegicus | |
0.039 | - |
L-carnitine | purified recombinant L-CPT I, reconstituted in liposomes | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | 2 isoforms of CPT I, L-CPT I and M-CPT I | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + L-carnitine | Rattus norvegicus | enzyme has a key function in regulation of fatty acid beta-oxidation | CoA + L-acylcarnitine | - |
? | |
acyl-CoA + L-carnitine | Rattus norvegicus | CPT I, involved in regulation of fatty acid oxidation | CoA + L-acylcarnitine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
enzyme form CPT I | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged L-CPT I from Pichia pastoris | Rattus norvegicus |
Renatured (Comment) | Organism |
---|---|
reconstitution of recombinant L-CPT I from Pichia pastoris in phospholipids after purification with detergent extraction | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | L-CPT I | Rattus norvegicus | - |
liver | M-CPT I | Rattus norvegicus | - |
liver | CPT I | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.473 | - |
purified recombinant L-CPT I, reconstituted in liposomes | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-acylcarnitine | - |
? | |
acyl-CoA + L-carnitine | enzyme has a key function in regulation of fatty acid beta-oxidation | Rattus norvegicus | CoA + L-acylcarnitine | - |
? | |
acyl-CoA + L-carnitine | CPT I, involved in regulation of fatty acid oxidation | Rattus norvegicus | CoA + L-acylcarnitine | - |
? | |
palmitoyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-palmitoylcarnitine | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
7.2 | - |
assay at | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.6 | 8.8 | L-CPT I | Rattus norvegicus |