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2.3.1.21: carnitine O-palmitoyltransferase

This is an abbreviated version!
For detailed information about carnitine O-palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.21

Reaction

palmitoyl-CoA
+
L-carnitine
=
CoA
 +
L-palmitoylcarnitine

Synonyms

acylcarnitine transferase, carnitine O-palmitoyltransferase, carnitine O-palmitoyltransferase I, carnitine palmitoyl transferase 1, carnitine palmitoyl transferase 1A, carnitine palmitoyl transferase-1A, carnitine palmitoyl transferase-I, carnitine palmitoyl-transferase-1c, carnitine palmitoyltransferae 1A, carnitine palmitoyltransferase, carnitine palmitoyltransferase 1, carnitine palmitoyltransferase 1A, carnitine palmitoyltransferase 1B, carnitine palmitoyltransferase 2, carnitine palmitoyltransferase I, carnitine palmitoyltransferase IA, carnitine palmitoyltransferase II, carnitine palmitoyltransferase-1, carnitine palmitoyltransferase-1c, carnitine palmitoyltransferase-A, carnitine palmitoyltransferase-I, carnitine palmitoyltransferases 2, CPT, CPT I, CPT IA, CPT Ialpha1a, CPT Ialpha1b, CPT Ialpha2a, CPT Ibeta, CPT II, CPT-1, CPT-2, CPT-A, CPT-B, CPT-Ialpha, CPT-IL, CPT1, CPT1-A, CPT1-B, CPT1-C, CPT1A, CPT1B, CPT1c, CPT2, CPTi, CPTI beta, CPTII, CPTo, L-carnitine palmitoyltransferase, L-CPT 1, L-CPT1, M-CPT 1, M-CPTI, muscle carnitine palmitoyltransferase I, palmitoylcarnitine transferase, palmitoyltransferase, carnitine

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.21 carnitine O-palmitoyltransferase

Specific Activity

Specific Activity on EC 2.3.1.21 - carnitine O-palmitoyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00018
mutant enzyme F352C/V368I, at 30°C, pH not specified in the publication
0.00027
mutant enzyme V368I, at 30°C, pH not specified in the publication
0.00028
wild type enzyme, at 30°C, pH not specified in the publication
0.00035
-
transfected HEK-293T cell
0.0006
hepatocytes transduced with adenovirus encoding beta-galctosidase exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period
0.00062
F352C/V368I/V605L mutant protein, COS-7 cell lysate
0.00063
wild-type protein and F352C/V368I/V605L mutant protein, COS-7 cell lysate (doubly transfected)
0.00071
P504L/V605L mutant protein, COS-7 cell lysate
0.00072
0.00073
F352C mutant protein, COS-7 cell lysate
0.00076
P504L mutant protein, COS-7 cell lysate
0.00078
V605L mutant protein, COS-7 cell lysate
0.0008
hepatocytes transduced with adenovirus encoding CPT-2 exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period
0.00081
M647V mutant protein, COS-7 cell lysate
0.00085
V368I mutant protein, COS-7 cell lysate
0.00087
wild-type protein, COS-7 cell lysate
0.001
0.0013
0.0014
-
CPT I after gamma-linoleic acid treatment
0.0017
hepatocytes transduced with adenovirus encoding CPT-1a exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period
0.0019
hepatocytes transduced with adenovirus encoding CPT-1a exposed to exogenous palmitate, measurement of CPT-2 activity at the end of the incubation period
0.00194
-
transfectecd PC-12 cell
0.002
-
CPT II, red muscle
0.0021
0.00227
-
mitochondrial fraction, wild-type protein expressed in COS-7 cell
0.00279
-
wild-type protein, mitochondrial preparation
0.0028
-
recombinant revertant A305C
0.0029
0.0032
0.0033
hepatic CPT-1 activity, rats fed high-fat diet, transduced with adenovirus encoding CPT-2, incubation with palmitate
0.0036
0.0041
hepatic CPT-1 activity, rats fed standard diet, transduced with adenovirus encoding CPT-1a, incubation with palmitate
0.00416
-
chimeric protein: residues 1-128 of human enzyme recombined with pig enzyme, mitochondrial preparation
0.00443
-
wild-type protein, mitochondrial preparation
0.00449
-
chimeric protein: residues 1-50 of human enzyme recombined with pig enzyme, mitochondrial preparation
0.0046
-
CPT II, liver
0.0047
-
CPT I, heart, plus 50 microM malonyl-CoA
0.0051
hepatic CPT-1 activity, rats fed high-fat diet, transduced with adenovirus encoding CPT-1a, incubation with palmitate
0.0052
-
recombinant wild-type L-CPT I
0.0054
0.0062
-
cell line 3T3-L1, CPT II, 6 days after differentiation
0.0063
hepatocytes transduced with adenovirus encoding CPT-2 exposed to exogenous palmitate, measurement of CPT-2 activity at the end of the incubation period
0.0069
-
mitochondrial fraction of recombinant Pichia pastoris expressing CPT II
0.0073
-
solubilized CPT
0.0078
-
recombinant wild-type L-CPT I
0.0081
-
CPT I, liver
0.0083
-
CPT II, white muscle
0.009
-
CPT I
0.00942
-
protein with deletion of residue 1-28, mitochondrial preparation
0.00943
-
chimeric protein: residues 1-50 of pig enzyme recombined with human enzyme, mitochondrial preparation
0.01059
-
chimeric protein: residues 1-128 of pig enzyme recombined with human enzyme, mitochondrial preparation
0.0106
-
CPT II, heart
0.0128
-
CPT I, red muscle, plus 50 microM malonyl-CoA
0.0148
-
CPT I, white muscle
0.01528
-
protein with deletion of residue 1-18, mitochondrial preparation
0.0168
-
CPT I, heart
0.0263
-
CPT I, red muscle
0.0367
-
mitochondrial fraction, 1 mM palmitoyl-CoA
0.0565
-
mitochondrial fraction
0.43
-
recombinant CPT II from Sf 9 insect cells
0.473
-
purified recombinant L-CPT I, reconstituted in liposomes
13.2
-
purified peroxisomal enzyme
24
-
purified enzyme
29.6
-
purified enzyme
33
mutant S113L, pH 7.4, 30°C
39
wild-type, pH 7.4, 30°C
4.65
-
purified mitochondrial enzyme
40
-
purified enzyme
42
-
purified enzyme
47.5
-
purified enzyme
additional information