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2.3.1.21: carnitine O-palmitoyltransferase

This is an abbreviated version!
For detailed information about carnitine O-palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.21

Reaction

palmitoyl-CoA
+
L-carnitine
=
CoA
 +
L-palmitoylcarnitine

Synonyms

acylcarnitine transferase, carnitine O-palmitoyltransferase, carnitine O-palmitoyltransferase I, carnitine palmitoyl transferase 1, carnitine palmitoyl transferase 1A, carnitine palmitoyl transferase-1A, carnitine palmitoyl transferase-I, carnitine palmitoyl-transferase-1c, carnitine palmitoyltransferae 1A, carnitine palmitoyltransferase, carnitine palmitoyltransferase 1, carnitine palmitoyltransferase 1A, carnitine palmitoyltransferase 1B, carnitine palmitoyltransferase 2, carnitine palmitoyltransferase I, carnitine palmitoyltransferase IA, carnitine palmitoyltransferase II, carnitine palmitoyltransferase-1, carnitine palmitoyltransferase-1c, carnitine palmitoyltransferase-A, carnitine palmitoyltransferase-I, carnitine palmitoyltransferases 2, CPT, CPT I, CPT IA, CPT Ialpha1a, CPT Ialpha1b, CPT Ialpha2a, CPT Ibeta, CPT II, CPT-1, CPT-2, CPT-A, CPT-B, CPT-Ialpha, CPT-IL, CPT1, CPT1-A, CPT1-B, CPT1-C, CPT1A, CPT1B, CPT1c, CPT2, CPTi, CPTI beta, CPTII, CPTo, L-carnitine palmitoyltransferase, L-CPT 1, L-CPT1, M-CPT 1, M-CPTI, muscle carnitine palmitoyltransferase I, palmitoylcarnitine transferase, palmitoyltransferase, carnitine

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.21 carnitine O-palmitoyltransferase

Activating Compound

Activating Compound on EC 2.3.1.21 - carnitine O-palmitoyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
carbacyclin
cardiolipin
-
inhibits conversion of palmitoylcarnitine to palmitoyl-CoA, stimulates palmitoylcarnitine formation
cholate
-
activates only CPTi
daidzein
di(2-ethyl-hexyl)phtalate
-
-
genistein
L-carnitine
liothyronine
-
-
octyl glucoside
-
only CPTi
palmitoylcarnitine
-
high above micellar concentrations increase conversion of palmitoylcarnitine to palmitoyl-CoA by facilitating the removal of palmitoyl-CoA from the enzyme surface
PGC-1beta
-
peroxisome proliferator activated receptor gamma coactivator
-
Phosphatidylcholine liposomes
-
Phospholipids
-
e.g. phosphatidylcholine, cardiolipin, stimulate
Proteins
-
e.g. albumin, fatty acid-binding protein, lambda-globulin, stimulate
-
salicylic acid
-
activates best at 20 mM, pH changes
Triton X-100
-
only CPTi
Tween 20
additional information
-
clofibrate induces the enzyme expression in transfected Huh-7 cells
-