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Literature summary for 2.3.1.21 extracted from

  • Woldegiorgis, G.; Bremer, J.; Shrago, E.
    Substrate inhibition of carnitine palmitoyltransferase by palmitoyl-CoA and activation by phospholipids and proteins (1985), Biochim. Biophys. Acta, 837, 135-140.
    View publication on PubMed
Search for more literature for 2.3.1.21

Activating Compound

Activating Compound Comment Organism Structure
Phospholipids e.g. phosphatidylcholine, cardiolipin, stimulate Rattus norvegicus
Proteins e.g. albumin, fatty acid-binding protein, lambda-globulin, stimulate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
palmitoyl-CoA substrate inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information it is suggested that the enzyme contains hydrophobic sites which require phospholipid to prevent spurious binding of palmitoyl-CoA and which normally anchor the enzyme to the mitochondrial membrane Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
CPTo and CPTi, partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 ?