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2.3.1.21: carnitine O-palmitoyltransferase

This is an abbreviated version!
For detailed information about carnitine O-palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.21

Reaction

palmitoyl-CoA
+
L-carnitine
=
CoA
+
L-palmitoylcarnitine

Synonyms

acylcarnitine transferase, carnitine O-palmitoyltransferase, carnitine O-palmitoyltransferase I, carnitine palmitoyl transferase 1, carnitine palmitoyl transferase 1A, carnitine palmitoyl transferase-1A, carnitine palmitoyl transferase-I, carnitine palmitoyl-transferase-1c, carnitine palmitoyltransferae 1A, carnitine palmitoyltransferase, carnitine palmitoyltransferase 1, carnitine palmitoyltransferase 1A, carnitine palmitoyltransferase 1B, carnitine palmitoyltransferase 2, carnitine palmitoyltransferase I, carnitine palmitoyltransferase IA, carnitine palmitoyltransferase II, carnitine palmitoyltransferase-1, carnitine palmitoyltransferase-1c, carnitine palmitoyltransferase-A, carnitine palmitoyltransferase-I, carnitine palmitoyltransferases 2, CPT, CPT I, CPT IA, CPT Ialpha1a, CPT Ialpha1b, CPT Ialpha2a, CPT Ibeta, CPT II, CPT-1, CPT-2, CPT-A, CPT-B, CPT-Ialpha, CPT-IL, CPT1, CPT1-A, CPT1-B, CPT1-C, CPT1A, CPT1B, CPT1c, CPT2, CPTi, CPTI beta, CPTII, CPTo, L-carnitine palmitoyltransferase, L-CPT 1, L-CPT1, M-CPT 1, M-CPTI, muscle carnitine palmitoyltransferase I, palmitoylcarnitine transferase, palmitoyltransferase, carnitine

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.21 carnitine O-palmitoyltransferase

Inhibitors

Inhibitors on EC 2.3.1.21 - carnitine O-palmitoyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11-trimethylamino-undecanoyl-DL-carnitine
-
-
2-bromoacetyl-CoA
-
-
2-bromopalmitoyl-CoA
2-[5(4-chlorophenyl)pentyl]-oxirane-2-carboxyl-CoA
-
-
4-hydroxy phenylglyoxylate
-
CPT I, greatly reduced inhibition of protease treated enzyme
acetyl-CoA
arachidonic acid
-
the enzymatic activity significantly declines by treatment with 0.1 mM for 1 h
Bile acids
-
e.g. in cholestatic rats
bromoacetyl-CoA
-
-
C75-CoA
cardiolipin
-
inhibits conversion of palmitoylcarnitine to palmitoyl-CoA, stimulates palmitoylcarnitine formation
carnitine
-
CPT I, slightly
chenodeoxycholic acid
-
competitive to carnitine
cholate
-
only CPTo
CoA esters of certain oxirane carboxylic acids
-
deoxycarnitine
-
-
diethyl dicarbonate
-
CPT II, strong, linear pseudo-first order kinetic, modification of a histidine residue, reversible by hydroxylamine, decanoyl-CoA and L-carnitine
Digitonin
-
CPTo and slightly CPTi
dinitrophenyl analogue of etomoxir
-
i.e. 2[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylic acid, DNP-Et, specific inhibitor for liver L-CPT I, identical with the small isoform of heart CPT I, complete inhibition of L-CPT I, but not M-CPT I
etomoxir
etomoxir-CoA
-
CPTo
etomoxiryl-CoA
gamma-linolenic acid
-
inhibits CPT I in vivo and reduces malonyl-CoA sensitivity, decreases affinity for 16:0 acyl-CoA substrate
H2O2
-
the enzymatic activity significantly and reversibly declines by 1 mM H2O2
Hemipalmitoylcarnitinium bromide
L-aminocarnitine
L-palmitoylcarnitine
-
competitive product inhibition
L-sulfocarnitine
-
ability to act as substrate or inhibitor of CPT is dependent on the nature of CPT and on the chain length of the acyl-CoA cosubstrate
malonyl CoA
-
a physiological CPT1 inhibitor
malonyl-CoA
methylmalonyl-CoA
nagarse
-
mitochondria, malonyl-CoA protects
-
octyl glucoside
octyl-glucoside
-
-
oxfenicine
palmitoyl-CoA
palmitoylcarnitine
-
-
Palmitoylcholine
-
competitive in the forward reaction to both substrates
phosphatidylcholine
-
-
propionyl-CoA
-
CPT I, inhibition is not affected by proteinase treatment
Ro 25-0187
-
CPT I, strong, inhibitory effect is drastically reduced by protease treatment of outer mitochondrial membrane; malonyl-CoA analogue
rotenone
-
the enzymatic activity significantly declines by treatment with 0.001 mM for 2 h
S-(4-bromo-2,3-dioxobutyl)-CoA
-
inhibition of malonyl-CoA sensitive enzyme, malonyl-CoA insensitive enzyme is not inhibited
Short chain-length fatty acylcarnitine derivatives
-
-
-
succinyl-CoA
-
partial proteolysis of CPT I slightly diminishes the inhibitory effect
tetradecylglycidyl-CoA
thiolcarnitine
-
ability to act as substrate or inhibitor of CPT is dependent on the nature of CPT and on chain length of the acyl-CoA cosubstrate
trans-2-hexadecenoyl-CoA
competitive
Triton X-100
Trypsin
-
tumor necrosis factor-alpha
-
the enzymatic activity significantly declines by treatment with 25 ng/ml for 30 min
-
Tween 20
additional information
-