Any feedback?
Literature summary for 2.3.1.21 extracted from
- Fatty acyl group transport into mitochondria: carnitine palmitoyl transferases EC 2.3.1.23 and the carnitine-acylcarnitine translocase (1979), Methods Enzymol., 56, 368-378.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0055 | - |
CoA | - |
Bos taurus |  |
| 0.018 | - |
palmitoyl-CoA | - |
Bos taurus | |
| 0.14 | - |
L-palmitoylcarnitine | - |
Bos taurus | |
| 0.45 | - |
L-carnitine | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial inner membrane | enzyme is present on both sides of the inner membrane, not on the outer membrane | Rattus norvegicus | 5743 | - |
| mitochondrial inner membrane | enzyme is present on both sides of the inner membrane, not on the outer membrane | Bos taurus | 5743 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
| additional information | transport mechanism for acylcaritine and carnitine through the mitochondrial inner membrane | Rattus norvegicus | - |
- |
| additional information | transport mechanism for acylcaritine and carnitine through the mitochondrial inner membrane | Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Rattus norvegicus | - |
CoA + L-acylcarnitine | - |
? | |
| acyl-CoA + L-carnitine | Bos taurus | - |
CoA + L-acylcarnitine | - |
? | |
| additional information | Rattus norvegicus | participates in fatty acyl group transport into mitochondria | ? | - |
? | |
| additional information | Bos taurus | participates in fatty acyl group transport into mitochondria | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| calf liver | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| heart | - |
Bos taurus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-acylcarnitine | - |
? | |
| acyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-acylcarnitine | - |
r | |
| acyl-CoA + L-carnitine | - |
Bos taurus | CoA + L-acylcarnitine | - |
? | |
| acyl-CoA + L-carnitine | - |
Bos taurus | CoA + L-acylcarnitine | reverse reaction with palmitoylcarnitine | r | |
| acyl-CoA + L-carnitine | - |
Bos taurus | CoA + L-acylcarnitine | reverse reaction: myristoylcarnitine | r | |
| additional information | participates in fatty acyl group transport into mitochondria | Rattus norvegicus | ? | - |
? | |
| additional information | participates in fatty acyl group transport into mitochondria | Bos taurus | ? | - |
? | |
| myristoyl-CoA + L-carnitine | - |
Bos taurus | CoA + L-myristoylcarnitine | - |
? | |
| palmitoyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-palmitoylcarnitine | - |
r | |
| palmitoyl-CoA + L-carnitine | - |
Bos taurus | CoA + L-palmitoylcarnitine | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8.2 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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