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Literature summary for 2.3.1.21 extracted from

  • Weis, B.C.; Cowan, A.T.; Brown, N.; Foster, D.W.; McGarry, J.D.
    Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme (1994), J. Biol. Chem., 269, 26443-26448.
    View publication on PubMed
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
dinitrophenyl analogue of etomoxir i.e. 2[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylic acid, DNP-Et, specific inhibitor for liver L-CPT I, identical with the small isoform of heart CPT I, complete inhibition of L-CPT I, but not M-CPT I Rattus norvegicus
malonyl-CoA inhibition of isoform L-CPT I is increased by 2[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylic acid Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
 L-carnitine isoform L-CPT I Rattus norvegicus
0.5
-
 L-carnitine isoform L-CPT I, with 2[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylic acid Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 2 isoforms of CPT I in heart mitochondria, liver L-CPT I, skeletal muscle M-CPT I
-
Rattus norvegicus
-
 enzyme form CPT I
-

Source Tissue

Source Tissue Comment Organism Textmining
heart 2 isoforms of CPT I Rattus norvegicus
-
liver L-CPT I Rattus norvegicus
-
additional information liver L-CPT I is identical with the small isoform CPT I from heart, the large isoform of CPT I from heart resembles M-CPT I from skeletal muscle Rattus norvegicus
-
skeletal muscle M-CPT I Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?