7.2.2.19: H+/K+-exchanging ATPase
This is an abbreviated version!
For detailed information about H+/K+-exchanging ATPase, go to the full flat file.
Word Map on EC 7.2.2.19
-
7.2.2.19
-
parietal
-
mucosa
-
omeprazole
-
stomach
-
na,k-atpase
-
alpha-subunits
-
ulcer
-
histamine
-
beta-subunits
-
helicobacter
-
atpases
-
gastritis
-
pylori
-
gastrin
-
antisecretory
-
basolateral
-
tubulovesicles
-
reflux
-
benzimidazole
-
lansoprazole
-
oxyntic
-
fundic
-
histamine-stimulated
-
pepsinogen
-
k+-stimulated
-
pernicious
-
cimetidine
-
k+-dependent
-
acid-related
-
h2-receptor
-
antiulcer
-
rabeprazole
-
pentagastrin
-
h-atpase
-
phosphoenzyme
-
acid-secreting
-
tubulovesicular
-
hypergastrinemia
-
gastroprotective
-
bcecf
-
ranitidine
-
canaliculus
-
ouabain-insensitive
-
pylorus-ligated
-
ion-transporting
-
achlorhydria
-
thymectomy
-
hypochlorhydria
-
pharmacology
-
medicine
-
14caminopyrine
-
zollinger-ellison
- 7.2.2.19
-
parietal
- mucosa
- omeprazole
- stomach
- na,k-atpase
- alpha-subunits
- ulcer
- histamine
- beta-subunits
- helicobacter
- atpases
- gastritis
- pylori
- gastrin
-
antisecretory
-
basolateral
-
tubulovesicles
- reflux
- benzimidazole
- lansoprazole
-
oxyntic
- fundic
-
histamine-stimulated
- pepsinogen
-
k+-stimulated
-
pernicious
- cimetidine
-
k+-dependent
-
acid-related
-
h2-receptor
-
antiulcer
- rabeprazole
- pentagastrin
-
h-atpase
- phosphoenzyme
-
acid-secreting
-
tubulovesicular
-
hypergastrinemia
-
gastroprotective
-
bcecf
- ranitidine
-
canaliculus
-
ouabain-insensitive
-
pylorus-ligated
-
ion-transporting
- achlorhydria
-
thymectomy
- hypochlorhydria
- pharmacology
- medicine
-
14caminopyrine
-
zollinger-ellison
Reaction
Synonyms
(H++K+)-ATPase, Atp12a, ATP1al1, ATP4A, ATP4B, EC 3.6.1.36, EC 3.6.3.10, electroneutral H+/K+-ATPase, gastric (H+, K+)-ATPase, gastric H+,K+-ATPase, gastric H+/K+-ATPase, gastric H+K+-ATPase, gastric H,K-ATPase, gastric H/K-ATPase, gastric HK-ATPase, gastric proton pump, H(+),K(+)-ATPase, H+, K+-ATPase, H+,K+ ATPase, H+,K+-adenosine triphosphatase, H+,K+-ATPase, H+-K+-adenosinetriphosphatase, H+-K+-ATPase, H+-K+-ATPase alpha2, H+/K+ ATPase, H+/K+ pump, H+/K+-ATPase, H+K+-ATPase, H,K-ATPase, H-K-ATPase, HKA, HKalpha1, HKalpha2, HKbeta, More, non-gastric H+/K+ ATPase, non-gastric H+/K+ATPase, non-gastric H,K-ATPase, nongastric H+-K+-ATPase, nongastric H,K-ATPase, nongastric H-K-ATPase, ouabain-sensitive H+/K+-ATPase, Proton pump
ECTree
7.2.2.19 H+/K+-exchanging ATPaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 7.2.2.19 - H+/K+-exchanging ATPase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the known requirement for H+/K+-ATPase function in chick asymmetry does not function through effects on the circumferential expression pattern of Connexin43, physiological function, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
H+,K+-ATPase family of ion pumps is an essential component of the kidneys K+ and H+ transporting machinery, under normal circumstances as well as during adaption to physiological stress
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
isoform HKalpha(1) and HKalpha(4) are present in the collecting ducts of the human kidney and might contribute to H+ and K+ transport by the kidney
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
K+-Cl- cotransporter KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H+/K+-ATPase alpha2 gene of renal collecting duct and distal colon plays a central role in potassium and acid-base homeostasis, regulation, overview. Sp1 plays an important and positive role in controlling basal HKalpha2 gene expression in mIMCD3 cells in vivo and in vitro
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
involved in urinary acidification
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
acid-secretory role of the enzyme is coupled to K+ movement, enzyme activity is increased under conditions of chronic metabolic acidosis
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
gastric H,K-ATPase is an electroneutral transmembrane pump that moves protons from the cytoplasm of the parietal cell into the gastric lumen in exchange for potassium ions. The mechanism of transport against the established electrochemical gradients includes intermediate conformations in which the transferred ions are trapped within the membrane domain of the pump. The pump cycle involves switching between the E1 and E2P states. Molecular dynamics simulations on homology models of the E2P and E1 states amd K+ transport mechanism, overview. Movement of the M1M2 transmembrane segments, and the displacement of residues Q159, E160, Q110, and T152 during the conformational change, as well as the motions of E343 and L346, acted as the cytoplasmic-side gate
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the enzyme is involved in acid secretion in gastric mucosa
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
involved in urinary acidification
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
ir
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the enzyme could contribute to potassium and pH i regulation in cardiomyocytes
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the enzyme participates in K+ absorption and H+ secretion in the renal medulla, it is highly regulated in response to acid-base and electrolyte disturbances, colonic HKalpha2 plays a role in K+ and acid-base homeostasis as well as in early growth and development, it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
the electroneutral exchange of two cytoplasmic protons for two luminal potassium ions is achieved by the hydrolysis of one ATP molecule
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
Turtle
-
primary role may be in active potassium reabsorption
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the K+-Cl- cotransport by KCC4 is tightly coupled with H+/K+ antiport by H+,K+-ATPase
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the enzyme is involved in acid secretion from gastric mucosa, overview
-
-
?
additional information
?
-
-
the H+-K+-ATPase is associated with the sonic hedgehog protein in membranes of gastric parietal cells. Stimulation of acid secretion in parietal cells is characterized by a change in the distribution of the H+-K+-ATPase fron the P3 microsomal membrane fraction to the P1 plasma membrane fraction, mechanism, overview
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the enzyme is involved in acid secretion from gastric mucosa, overview
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the potassium channel KCNQ1, a 6-transmembrane member of the K+ channel family, provides an exit path for K+ ions brought in by the H+,K+-ATPase, overview. The KCNQ1 channel is also required for gastric acid secretion, where it works together with the H+/K+-ATPase
-
-
?
