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Literature summary for 7.2.2.19 extracted from

  • Paresi, C.J.; Liu, Q.; Li, Y.M.
    Benzimidazole covalent probes and the gastric H+/K+-ATPase as a model system for protein labeling in a copper-free setting (2016), Mol. Biosyst., 12, 1772-1780 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.19

Inhibitors

Inhibitors Comment Organism Structure
2-[(4-[4-[4-(azidomethyl)phenoxy]butoxy]-3-methylpyridin-2-yl)methanesulfinyl]-1H-benzimidazole inhibits ATPase activity by approximately 50% at 0.01 mM Sus scrofa
4-([2-[(1H-benzimidazole-2-sulfinyl)methyl]-3-methylpyridin-4-yl]oxy)butyl [4-(1,2,4,5-tetrazin-3-yl)phenyl]acetate inhibits ATPase activity by approximately 50% at 0.01 mM Sus scrofa
rabeprazole complete inhibition at 0.1 mM Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity, 2 mM used in assay conditions Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
270000
-
 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+[side 1] + K+[side 2] Sus scrofa
-
 ADP + phosphate + H+[side 2] + K+[side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa P19156
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
 Sus scrofa
-
stomach
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+[side 1] + K+[side 2]
-
 Sus scrofa ADP + phosphate + H+[side 2] + K+[side 1]
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 114000, calculated from amino acid sequence Sus scrofa

Synonyms

Synonyms Comment Organism
ATP4A
-
 Sus scrofa
H+/K+-ATPase
-
 Sus scrofa