Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.19 extracted from

  • Freitas, C.S.; Baggio, C.H.; Finau, J.; Anginoni, M.; Pizzolatti, M.G.; Santos, A.R.; Marques, M.C.
    Inhibition of H+/K+ ATPase in the gastroprotective effect of Baccharis illinita DC (2008), J. Pharm. Pharmacol., 60, 1105-1110.
    View publication on PubMed
Search for more literature for 7.2.2.19

Inhibitors

Inhibitors Comment Organism Structure
luteolin
-
 Oryctolagus cuniculus
luteolin
-
 Rattus norvegicus
additional information chlorofom extract of Baccharis illinita flowers inhibits the H+-K+-ATPase and gastric acid secretion in rabbit stomach, no inhibition by naringenin and kaempferol Oryctolagus cuniculus
additional information chlorofom extract of Baccharis illinita flowers inhibits the H+-K+-ATPase and gastric acid secretion in rat stomach Rattus norvegicus
Omeprazole
-
 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
membrane
-
 Oryctolagus cuniculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus
Mg2+ required Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in + K+/out Rattus norvegicus
-
 ADP + phosphate + H+/out + K+/in
-
 ?
ATP + H2O + H+/in + K+/out Oryctolagus cuniculus
-
 ADP + phosphate + H+/out + K+/in
-
 ?
additional information Rattus norvegicus the enzyme is involved in acid secretion from gastric mucosa, overview ?
-
 ?
additional information Oryctolagus cuniculus the enzyme is involved in acid secretion from gastric mucosa, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
 female Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
 Oryctolagus cuniculus
-
stomach
-
 Rattus norvegicus
-
stomach
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in + K+/out
-
 Rattus norvegicus ADP + phosphate + H+/out + K+/in
-
 ?
ATP + H2O + H+/in + K+/out
-
 Oryctolagus cuniculus ADP + phosphate + H+/out + K+/in
-
 ?
additional information the enzyme is involved in acid secretion from gastric mucosa, overview Rattus norvegicus ?
-
 ?
additional information the enzyme is involved in acid secretion from gastric mucosa, overview Oryctolagus cuniculus ?
-
 ?

Synonyms

Synonyms Comment Organism
H+-K+-ATPase
-
 Rattus norvegicus
H+-K+-ATPase
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus
37
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus
7.4
-
 assay at Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
ATP
-
 Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03
-
-
 Rattus norvegicus luteolin
0.03
-
-
 Oryctolagus cuniculus luteolin