7.2.2.19: H+/K+-exchanging ATPase
This is an abbreviated version!
For detailed information about H+/K+-exchanging ATPase, go to the full flat file.
Word Map on EC 7.2.2.19
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7.2.2.19
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parietal
-
mucosa
-
omeprazole
-
stomach
-
na,k-atpase
-
alpha-subunits
-
ulcer
-
histamine
-
beta-subunits
-
helicobacter
-
atpases
-
gastritis
-
pylori
-
gastrin
-
antisecretory
-
basolateral
-
tubulovesicles
-
reflux
-
benzimidazole
-
lansoprazole
-
oxyntic
-
fundic
-
histamine-stimulated
-
pepsinogen
-
k+-stimulated
-
pernicious
-
cimetidine
-
k+-dependent
-
acid-related
-
h2-receptor
-
antiulcer
-
rabeprazole
-
pentagastrin
-
h-atpase
-
phosphoenzyme
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acid-secreting
-
tubulovesicular
-
hypergastrinemia
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gastroprotective
-
bcecf
-
ranitidine
-
canaliculus
-
ouabain-insensitive
-
pylorus-ligated
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ion-transporting
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achlorhydria
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thymectomy
-
hypochlorhydria
-
pharmacology
-
medicine
-
14caminopyrine
-
zollinger-ellison
- 7.2.2.19
-
parietal
- mucosa
- omeprazole
- stomach
- na,k-atpase
- alpha-subunits
- ulcer
- histamine
- beta-subunits
- helicobacter
- atpases
- gastritis
- pylori
- gastrin
-
antisecretory
-
basolateral
-
tubulovesicles
- reflux
- benzimidazole
- lansoprazole
-
oxyntic
- fundic
-
histamine-stimulated
- pepsinogen
-
k+-stimulated
-
pernicious
- cimetidine
-
k+-dependent
-
acid-related
-
h2-receptor
-
antiulcer
- rabeprazole
- pentagastrin
-
h-atpase
- phosphoenzyme
-
acid-secreting
-
tubulovesicular
-
hypergastrinemia
-
gastroprotective
-
bcecf
- ranitidine
-
canaliculus
-
ouabain-insensitive
-
pylorus-ligated
-
ion-transporting
- achlorhydria
-
thymectomy
- hypochlorhydria
- pharmacology
- medicine
-
14caminopyrine
-
zollinger-ellison
Reaction
Synonyms
(H++K+)-ATPase, Atp12a, ATP1al1, ATP4A, ATP4B, EC 3.6.1.36, EC 3.6.3.10, electroneutral H+/K+-ATPase, gastric (H+, K+)-ATPase, gastric H+,K+-ATPase, gastric H+/K+-ATPase, gastric H+K+-ATPase, gastric H,K-ATPase, gastric H/K-ATPase, gastric HK-ATPase, gastric proton pump, H(+),K(+)-ATPase, H+, K+-ATPase, H+,K+ ATPase, H+,K+-adenosine triphosphatase, H+,K+-ATPase, H+-K+-adenosinetriphosphatase, H+-K+-ATPase, H+-K+-ATPase alpha2, H+/K+ ATPase, H+/K+ pump, H+/K+-ATPase, H+K+-ATPase, H,K-ATPase, H-K-ATPase, HKA, HKalpha1, HKalpha2, HKbeta, More, non-gastric H+/K+ ATPase, non-gastric H+/K+ATPase, non-gastric H,K-ATPase, nongastric H+-K+-ATPase, nongastric H,K-ATPase, nongastric H-K-ATPase, ouabain-sensitive H+/K+-ATPase, Proton pump
ECTree
7.2.2.19 H+/K+-exchanging ATPaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 7.2.2.19 - H+/K+-exchanging ATPase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyATP + H2O + H+/in + K+/out
2'-deoxyADP + phosphate + H+/out + K+/in
-
70% of the activity with ATP
-
-
?
2'-deoxyATP + H2O + H+/in + K+/out
2'-deoxyADP + phosphate + H+/out + K+/in
-
37% of the activity with ATP
-
-
?
ADP + H2O + H+/in + K+/out
AMP + phosphate + H+/out + K+/in
-
14% of the activity with ATP
-
-
?
ADP + H2O + H+/in + K+/out
AMP + phosphate + H+/out + K+/in
-
7.5% of the activity with ATP
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
a Na+-independent, ouabain-sensitive H+/K+-exchange. K+ can be replaced by H+ in the enzyme reaction cycle, however pH-induced conformational changes cannot be discarded
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the known requirement for H+/K+-ATPase function in chick asymmetry does not function through effects on the circumferential expression pattern of Connexin43, physiological function, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
H+,K+-ATPase family of ion pumps is an essential component of the kidneys K+ and H+ transporting machinery, under normal circumstances as well as during adaption to physiological stress
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
isoform HKalpha(1) and HKalpha(4) are present in the collecting ducts of the human kidney and might contribute to H+ and K+ transport by the kidney
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the enzyme can function as Na/K exchanger
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
K+-Cl- cotransporter KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H+/K+-ATPase alpha2 gene of renal collecting duct and distal colon plays a central role in potassium and acid-base homeostasis, regulation, overview. Sp1 plays an important and positive role in controlling basal HKalpha2 gene expression in mIMCD3 cells in vivo and in vitro
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
involved in urinary acidification
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
acid-secretory role of the enzyme is coupled to K+ movement, enzyme activity is increased under conditions of chronic metabolic acidosis
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
gastric H,K-ATPase is an electroneutral transmembrane pump that moves protons from the cytoplasm of the parietal cell into the gastric lumen in exchange for potassium ions. The mechanism of transport against the established electrochemical gradients includes intermediate conformations in which the transferred ions are trapped within the membrane domain of the pump. The pump cycle involves switching between the E1 and E2P states. Molecular dynamics simulations on homology models of the E2P and E1 states amd K+ transport mechanism, overview. Movement of the M1M2 transmembrane segments, and the displacement of residues Q159, E160, Q110, and T152 during the conformational change, as well as the motions of E343 and L346, acted as the cytoplasmic-side gate
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the enzyme is involved in acid secretion in gastric mucosa
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
involved in urinary acidification
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
ir
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the enzyme could contribute to potassium and pH i regulation in cardiomyocytes
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the enzyme participates in K+ absorption and H+ secretion in the renal medulla, it is highly regulated in response to acid-base and electrolyte disturbances, colonic HKalpha2 plays a role in K+ and acid-base homeostasis as well as in early growth and development, it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
cation binding sites in the transmembrane domains TM42 to TM6, E2-conformation-specific salt bridge between the side chains of Lys791 in TM5 and Glu820 in TM6 of the cation binding pocket
-
-
ir
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
-
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
protons are charge-transferred from the enzyme's alpha-subunit cytosolic side to H2O in sites 2 and 1, the H2O comes from cytosolic medium, and H3O+ in the sites are transported into lumen during the conformational transition from E1P to E2P, charge transfer pathway charge transfer pathway from hydronium ion in cytosolic medium to Glu345 in cation binding site 2: H3O+-Lys164-Gln161-Glu345
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H,K-ATPase is the final step of acid secretion
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
the electroneutral exchange of two cytoplasmic protons for two luminal potassium ions is achieved by the hydrolysis of one ATP molecule
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
The second ion species that can bind to the H,K-ATPase in the E1 conformation is K+ that competes with H+. Experimental activity measurement begins with the ion pump in the E1 state after treatment with nigericin
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
Turtle
-
primary role may be in active potassium reabsorption
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview
-
-
?
ATP + H2O + H+/in + K+/out
ADP + phosphate + H+/out + K+/in
-
the H+,K+-ATPase is electroneutral, exchanging two positive charges in each cycle
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
?
ATP + H2O + H+[side 1] + K+[side 2]
ADP + phosphate + H+[side 2] + K+[side 1]
-
-
-
?
CTP + H2O + H+/in + K+/out
CDP + phosphate + H+/out + K+/in
-
a Na+-independent, ouabain-sensitive H+/K+-exchange, low activity with CTP
-
-
?
CTP + H2O + H+/in + K+/out
CDP + phosphate + H+/out + K+/in
-
20% of the activity with ATP
-
?
CTP + H2O + H+/in + K+/out
CDP + phosphate + H+/out + K+/in
-
13.2% of the activity with ATP
-
-
?
GTP + H2O + H+/in + K+/out
GDP + phosphate + H+/out + K+/in
-
a Na+-independent, ouabain-sensitive H+/K+-exchange, low activity with GTP
-
-
?
GTP + H2O + H+/in + K+/out
GDP + phosphate + H+/out + K+/in
-
6% of the activity with ATP
-
?
ITP + H2O + H+/in + K+/out
IDP + phosphate + H+/out + K+/in
-
a Na+-independent, ouabain-sensitive H+/K+-exchange, low activity with ITP
-
-
?
ITP + H2O + H+/in + K+/out
IDP + phosphate + H+/out + K+/in
-
5% of the activity with ATP
-
?
UTP + H2O + H+/in + K+/out
UDP + phosphate + H+/out + K+/in
-
a Na+-independent, ouabain-sensitive H+/K+-exchange, low activity with UTP
-
-
?
UTP + H2O + H+/in + K+/out
UDP + phosphate + H+/out + K+/in
-
40% of the activity with ATP
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the enzyme is phosphorylated from [32P]-gamma-ATP, forming an acyl-phosphate bond, in an Mg2+-dependent, vanadate-sensitive process
-
-
?
additional information
?
-
-
the enzyme can transport Na+ in exchange for K+
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the K+-Cl- cotransport by KCC4 is tightly coupled with H+/K+ antiport by H+,K+-ATPase
-
-
?
additional information
?
-
-
the Atp1al1-betaHK complex exhibits significant ATPase activity in nominally K+-free medium. The addition of K+ stimulates the ATPhydrolysis up to 3fold
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the enzyme is involved in acid secretion from gastric mucosa, overview
-
-
?
additional information
?
-
-
the H+-K+-ATPase is associated with the sonic hedgehog protein in membranes of gastric parietal cells. Stimulation of acid secretion in parietal cells is characterized by a change in the distribution of the H+-K+-ATPase fron the P3 microsomal membrane fraction to the P1 plasma membrane fraction, mechanism, overview
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the enzyme is involved in acid secretion from gastric mucosa, overview
-
-
?
additional information
?
-
activity tests of the recombinantly expressed enzyme by Rb+ uptake measurements, and voltage clamp fluorometry for site-specific labeling of H,KATPase-expressing TMRM-labeled oocytes
-
-
?
additional information
?
-
-
enzyme behaves as a passive cationic antiport in the absence of ATP
-
-
?
additional information
?
-
-
enzyme reconstituted into artificial phosphatidylcholine/cholesterol vesicles catalyzes an electroneutral H+-Rb+ exchange
-
-
?
additional information
?
-
-
the enzyme also performs K+-dependent NTP hydrolysis, utilizing ATP, GTP, CTP, UTP, and ITP, and an NTP/ADP exchange reaction, overview
-
-
?
additional information
?
-
-
a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion
-
-
?
additional information
?
-
-
the potassium channel KCNQ1, a 6-transmembrane member of the K+ channel family, provides an exit path for K+ ions brought in by the H+,K+-ATPase, overview. The KCNQ1 channel is also required for gastric acid secretion, where it works together with the H+/K+-ATPase
-
-
?
