7.2.2.19: H+/K+-exchanging ATPase

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For detailed information about H+/K+-exchanging ATPase, go to the full flat file.

Reaction

Synonyms

(H++K+)-ATPase, Atp12a, ATP1al1, ATP4A, ATP4B, EC 3.6.1.36, EC 3.6.3.10, electroneutral H+/K+-ATPase, gastric (H+, K+)-ATPase, gastric H+,K+-ATPase, gastric H+/K+-ATPase, gastric H+K+-ATPase, gastric H,K-ATPase, gastric H/K-ATPase, gastric HK-ATPase, gastric proton pump, H(+),K(+)-ATPase, H+, K+-ATPase, H+,K+ ATPase, H+,K+-adenosine triphosphatase, H+,K+-ATPase, H+-K+-adenosinetriphosphatase, H+-K+-ATPase, H+-K+-ATPase alpha2, H+/K+ ATPase, H+/K+ pump, H+/K+-ATPase, H+K+-ATPase, H,K-ATPase, H-K-ATPase, HKA, HKalpha1, HKalpha2, HKbeta, More, non-gastric H+/K+ ATPase, non-gastric H+/K+ATPase, non-gastric H,K-ATPase, nongastric H+-K+-ATPase, nongastric H,K-ATPase, nongastric H-K-ATPase, ouabain-sensitive H+/K+-ATPase, Proton pump

ECTree

     7 Translocases

         7.2 Catalysing the translocation of inorganic cations

             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate

                7.2.2.19 H+/K+-exchanging ATPase

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Results	in table
13	Activating Compound
188	AA Sequence
15	Application
1	CAS Registry Number
26	Cloned(Commentary)
14	Cofactor
3	Crystallization (Commentary)
572	Disease/ Diagnostics
6	Expression
10	General Information
2	General Stability
97	IC50 Value
329	Inhibitors
59	Ki Value [mM]
15	KM Value [mM]
76	Localization
64	Metals/Ions
15	Molecular Weight [Da]
69	Natural Substrates/ Products (Substrates)
116	Organism
2	Pathway
5	PDB ID
22	pH Optimum
2	pH Range
15	Posttranslational Modification
176	Protein Variants
16	Purification (Commentary)
8	Reaction
1	Reaction Type
116	Reference
147	Source Tissue
15	Specific Activity [micromol/min/mg]
3	Storage Stability
145	Substrates and Products (Substrate)
38	Subunits
137	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]

Expression

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Expression on EC 7.2.2.19 - H+/K+-exchanging ATPase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

chronic acidosis and G protein-coupled receptor GPR4 increase HKalpha2 protein by increasing protein kinase A activity without altering HKalpha2 mRNA abundance. Heterologous expression of GPR4 is sufficient to increase both basal and acid-stimulated HKalpha2 expression. Upregulation of HKalpha2 by chronic acidosis is reversible

Rattus norvegicus

-

718552

exposure to light for 12 h does not affect the H+/NH+4-activated enzyme activity from the inner mantle

Tridacna squamosa

-

733915

exposure to light for 12 h leads to a significant decrease in H+/NH+4-activated enzyme activity from the outer mantle

Tridacna squamosa

-

733915

exposure to light for 12 h leads to a significant increase in H+/NH+4-activated-HKA activity from ctenidia

Tridacna squamosa

-

733915

PEG and mannitol treatments induce marked increases in H+-K+-ATPase in barley cultivars XZ5 and Tadmor

Hordeum vulgare

-

750421

trimethyltin chloride does not change the expression of H+/K+-ATPase protein and mRNA

Rattus norvegicus

-

713552