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7.2.2.19: H+/K+-exchanging ATPase

This is an abbreviated version!
For detailed information about H+/K+-exchanging ATPase, go to the full flat file.

Word Map on EC 7.2.2.19

Reaction

ATP
+
H2O
 +
H+[side 1]
 +
K+[side 2]
=
ADP
 +
phosphate
 +
H+[side 2]
 +
K+[side 1]

Synonyms

(H++K+)-ATPase, Atp12a, ATP1al1, ATP4A, ATP4B, EC 3.6.1.36, EC 3.6.3.10, electroneutral H+/K+-ATPase, gastric (H+, K+)-ATPase, gastric H+,K+-ATPase, gastric H+/K+-ATPase, gastric H+K+-ATPase, gastric H,K-ATPase, gastric H/K-ATPase, gastric HK-ATPase, gastric proton pump, H(+),K(+)-ATPase, H+, K+-ATPase, H+,K+ ATPase, H+,K+-adenosine triphosphatase, H+,K+-ATPase, H+-K+-adenosinetriphosphatase, H+-K+-ATPase, H+-K+-ATPase alpha2, H+/K+ ATPase, H+/K+ pump, H+/K+-ATPase, H+K+-ATPase, H,K-ATPase, H-K-ATPase, HKA, HKalpha1, HKalpha2, HKbeta, More, non-gastric H+/K+ ATPase, non-gastric H+/K+ATPase, non-gastric H,K-ATPase, nongastric H+-K+-ATPase, nongastric H,K-ATPase, nongastric H-K-ATPase, ouabain-sensitive H+/K+-ATPase, Proton pump

ECTree

     7 Translocases
         7.2 Catalysing the translocation of inorganic cations
             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.2.2.19 H+/K+-exchanging ATPase

IC50 Value

IC50 Value on EC 7.2.2.19 - H+/K+-exchanging ATPase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.171
(2E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-phenylprop-2-en-1-one
Canis lupus familiaris
-
pH 7.4, 37°C
0.029
(7R,8R,9R)-2,3,10-trimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol
Sus scrofa
wild type enzyme, at pH 7.6 and 37°C
0.000077
(7R,8R,9R)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol
Sus scrofa
wild type enzyme, at pH 7.6 and 37°C
0.0059
(8-[(2-ethyl-6-methylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyrazin-6-yl)methanol
Sus scrofa
-
pH 7.4, 22°C
0.173
1,3,5,6-tetrahydroxy-2-(3-hydroxy-3-methylbutyl)-xanthone
Canis lupus familiaris
-
pH 7.4, 37°C
1.605
1-hydroxy-3,5,6-tri-O-acetyl-2(3,3-dimethyl-allyl)-xanthone
Canis lupus familiaris
-
pH 7.4, 37°C
0.015
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5-trihydroxybenzylidene)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.022
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5trimethoxybenzylidene)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.248
3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.014
4-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'(3,4,5trimethoxybenzylidene)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.01
4-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5-trihydroxybenzylidene)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.241
4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.04
4-coumaric acid
Ovis aries
-
pH 6.5, 37°C
1.581
6-desoxyjacareubin
Canis lupus familiaris
-
pH 7.4, 37°C
0.11
8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine
Sus scrofa
wild type enzyme, at pH 7.6 and 37°C
0.0055
8-[(2-ethyl-6-methylbenzyl)amino]-N,2,3-trimethylimidazo[1,2-a]pyrazine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0064
8-[(2-ethyl-6-methylbenzyl)amino]-N,N,2,3-tetramethylimidazo[1,2-a]pyrazine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.005
8-[(2-ethyl-6-methylbenzyl)amino]-N-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.006
8-[(2-ethyl-6-methylbenzyl)amino]-N-(2-methoxyethyl)-2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0048
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0053
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-N,2,3-trimethylimidazo[1,2-a]pyridine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0063
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-N,N,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0047
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-N-(1-methoxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0057
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]oxy]-N,N,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0057
8-[[(1S,2S)-2-hydroxy-7-methoxy-2,3-dihydro-1H-inden-1-yl]oxy]-N,N,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0069
8-[[(1S,2S)-2-hydroxy-7-methyl-2,3-dihydro-1H-inden-1-yl]oxy]-N,N,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide
Sus scrofa
-
pH 7.4, 22°C
0.0062
AR-HO47108
Sus scrofa
-
pH 7.4, 22°C
0.0027
caffeic acid
Ovis aries
-
pH 6.5, 37°C
0.015
Cinnamic acid
Ovis aries
-
pH 6.5, 37°C
0.00075
digoxigenin
Rattus norvegicus
-
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C
0.00076
digoxin
Rattus norvegicus
-
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C
0.027
dihydro-ouabain
Rattus norvegicus
-
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C
0.034
ferulic acid
Ovis aries
-
pH 6.5, 37°C
0.132
gallic acid
Ovis aries
-
pH 6.5, 37°C
0.059
gentisic acid
Ovis aries
-
pH 6.5, 37°C
0.0015
ginger hydrolysed phenolic fraction
Ovis aries
-
pH 6.5, 37°C
-
0.0029
ginger-free phenolic fraction
Ovis aries
-
pH 6.5, 37°C
-
0.0467
jacareubin
Canis lupus familiaris
-
pH 7.4, 37°C
0.0193
lansoprazole
Ovis aries
-
pH 6.5, 37°C
0.03
luteolin
0.1095
mammea A/BA
Canis lupus familiaris
-
pH 7.4, 37°C
0.638
mammea C/OA
Canis lupus familiaris
-
pH 7.4, 37°C
0.0096
minimiflorin
Canis lupus familiaris
-
pH 7.4, 37°C
0.07
mundulin
Canis lupus familiaris
-
pH 7.4, 37°C
0.151
N'-(2,3-dibromobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.139
N'-(2,3-dibromobenzyliden)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.146
N'-(2,4-dichlorobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.131
N'-(2,4-dichlorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.18
N'-(2,4-difluorobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.169
N'-(2,4-difluorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.144
N'-(2-chloro-6-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)butane hydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.16
N'-(2-chloro-6-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.129
N'-(2-fluoro-5-nitrobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.142
N'-(2-fluoro-5-nitrobenzyliden)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.029
N'-(3,4-dihydroxy-5-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.024
N'-(3,4-dihydroxy-5-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.152
N'-(4-chlorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.134
N'-(4-chlorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.037
N'-(4-hydroxy-3-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.032
N'-(4-hydroxy-3-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl) butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.06
N'-(4-hydroxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.051
N'-(4-hydroxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.054
N'-(4-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.041
N'-(4-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.14
N'-(4-nitrobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.127
N'-(4-nitrobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.21
N'-benzylidene-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.197
N'-benzylidene-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.0069
N-(2-ethyl-6-methylbenzyl)-2,3-dimethyl-6-(pyrrolidin-1-ylcarbonyl)imidazo[1,2-a]pyrazin-8-amine
Sus scrofa
-
pH 7.4, 22°C
0.0055
N-(2-ethyl-6-methylbenzyl)-6-(methoxymethyl)-2,3-dimethylimidazo[1,2-a]pyrazin-8-amine
Sus scrofa
-
pH 7.4, 22°C
0.16
N-(4-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)butane hydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.17
N-(4-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
Ovis aries
-
at pH 7.5 and 37°C
0.003
oligomycin
Homo sapiens
-
pH 7.0, 37°C, recombinant enzyme, in presence of 10 mM NH4+, or 10 mM K+, or 100 mM Na+
0.41
Omeprazole
Canis lupus familiaris
-
pH 7.4, 37°C
0.0028
ouabagenin
Rattus norvegicus
-
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C
0.00031 - 0.0017
Ouabain
0.06 - 8
oubain
0.047
protocatechuic acid
Ovis aries
-
pH 6.5, 37°C
0.02 - 4
SCH 28080
0.0059
SCH 32651
Sus scrofa
-
pH 7.4, 22°C
0.00041 - 0.0011
SCH28080
0.00017
strophanthidin
Rattus norvegicus
-
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C
0.037
syringic acid
Ovis aries
-
pH 6.5, 37°C
0.0008 - 0.0016
vanadate
0.097
[(dihydroindenyl)oxy]acetic acid
Sus scrofa
-
endogenous Na+,K+-ATPase
0.011
[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]acetonitrile
Sus scrofa
wild type enzyme, at pH 7.6 and 37°C
0.054
[8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl]acetonitrile
Sus scrofa
wild type enzyme, at pH 7.6 and 37°C