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7.2.2.19: H+/K+-exchanging ATPase

This is an abbreviated version!
For detailed information about H+/K+-exchanging ATPase, go to the full flat file.

Word Map on EC 7.2.2.19

Reaction

ATP
+
H2O
 +
H+[side 1]
 +
K+[side 2]
=
ADP
 +
phosphate
 +
H+[side 2]
 +
K+[side 1]

Synonyms

(H++K+)-ATPase, Atp12a, ATP1al1, ATP4A, ATP4B, EC 3.6.1.36, EC 3.6.3.10, electroneutral H+/K+-ATPase, gastric (H+, K+)-ATPase, gastric H+,K+-ATPase, gastric H+/K+-ATPase, gastric H+K+-ATPase, gastric H,K-ATPase, gastric H/K-ATPase, gastric HK-ATPase, gastric proton pump, H(+),K(+)-ATPase, H+, K+-ATPase, H+,K+ ATPase, H+,K+-adenosine triphosphatase, H+,K+-ATPase, H+-K+-adenosinetriphosphatase, H+-K+-ATPase, H+-K+-ATPase alpha2, H+/K+ ATPase, H+/K+ pump, H+/K+-ATPase, H+K+-ATPase, H,K-ATPase, H-K-ATPase, HKA, HKalpha1, HKalpha2, HKbeta, More, non-gastric H+/K+ ATPase, non-gastric H+/K+ATPase, non-gastric H,K-ATPase, nongastric H+-K+-ATPase, nongastric H,K-ATPase, nongastric H-K-ATPase, ouabain-sensitive H+/K+-ATPase, Proton pump

ECTree

     7 Translocases
         7.2 Catalysing the translocation of inorganic cations
             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.2.2.19 H+/K+-exchanging ATPase

Cloned

Cloned on EC 7.2.2.19 - H+/K+-exchanging ATPase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
beta-subunit
-
beta-subunit expressed in Xenopus laevis oocytes
-
catalytic subunit of the enzyme, in which several amino acids from Na,K-ATPase are incorporated, expressed with the Na,K-ATPase beta1 subunit in Xenopus laevis oocytes, expression of non-gastric H,K-ATPase-EGPLC and the Na,K-ATPase beta1-subunit in Sf9 cells using the baculovirus expression system
-
co-expression of wild-type and mutant beta- and alpha-subunits
-
efficient formation of the functional Atp1al1-betaHK complex in membranes of Sf-212-insect cells. Atp1al1-betaHK is a complex of the alpha-subunit of human nongastric H,K-ATPase with the gastric H,K-ATPase beta-subunit
-
expressed in HEK-293S GnT1 cells
expressed in HEK-293S GnT1- cells
-
expressed in Xenopus laevis oocytes
-
expression in HEK-293 cells
-
expression in Xenopus oocytes
-
expression of alpha-subunit of wild-type and mutant enzymes in Spodopera frugiperda Sf9 cell membranes using the baculovirus transfection system
-
expression of non-gastric enzyme in Spodoptera frugiperda Sf9 cells via baculovirus transfection, co-expression with the Rattus norvegicus beta1 subunit of Na,K-ATPase
-
expression of several chimeras between ATP1AL1 and the Na,K-ATPase in MDCK cells
expression of the beta-subunit and a modified form of the alpha-subunit with a single cysteine replacement in the TM5/TM6 extracellular loop, i.e. S806C, in Xenopus laevis oocytes
expression of the wild-type H,K-ATPase, alpha- and beta-subunits, and glycosylation-deficient Asn-to-Gln beta-mutants in Xenopus laevis oocytes
-
expression of wild-type and mutant enzymes in HEK-293 cells, expression analysis, overview
-
functional expression of the HKalpha2 subunit in human HEK-293 cells, human GPR4 is transiently transfected into HEK-293 cells stably expressing HKalpha2/NKbeta1, expression levels under different conditions by realtime PCR expression analysis
-
gene HKalpha2, the -144/-135 element is important for HKalpha2 promoter activity, regulation of gene expression and interaction with Sp1 protein, expression analysis, overview
-
into pcDNA3.1(+)-Neo, cotransfection of HEK-293 cells with H+,K+-ATPase alpha subunit plus Na+,K+-ATPase beta1 subunit or beta3 subunit, respectively
-
into pcDNA3.1(+)-Neo, expression in HEK-293 cells, mutant cloned into pEGFP-2C vector
-
overexpression in Sf-21 cells as a control
-
regulation of colonic HKalpha2 transcription and expression, overview
-
transfection of Saccharomyces cerevisiae AH109 with pGBKT7 containing an insert encoding the 84 carboxy-terminal acids of HKalpha2, cotransfection of HEK-293 cells with HKalpha2 plus NKbeta1