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Literature summary for 7.2.2.19 extracted from
- Inhibition of gastric H+,K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale (2007), Mol. Nutr. Food Res., 51, 324-332.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-coumaric acid | - |
Ovis aries |  |
| caffeic acid | - |
Ovis aries | |
| Cinnamic acid | - |
Ovis aries | |
| ferulic acid | - |
Ovis aries | |
| gallic acid | - |
Ovis aries | |
| gentisic acid | - |
Ovis aries | |
| ginger hydrolysed phenolic fraction | of ginger, Zingiber officinale, rhizome, constituted by cinnamic (48%), 4-coumaric (34%) and caffeic (6%) acids as major phenolic acids, as potent inhibitors of gastric cell proton potassium ATPase activity and Helicobacter pylori growth, exhibiting strong antioxidant potency, overview | Ovis aries | |
| ginger-free phenolic fraction | the fraction is constituted by syringic (38%), gallic (18%) and cinnamic (14%) acids, as potent inhibitors of gastric cell proton potassium ATPase activity and Helicobacter pylori growth, exhibiting strong antioxidant potency, overview | Ovis aries | |
| lansoprazole | - |
Ovis aries | |
| additional information | determination of minimal inhibitory concentration, MIC, values | Ovis aries | |
| protocatechuic acid | - |
Ovis aries | |
| syringic acid | - |
Ovis aries | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Ovis aries | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Ovis aries | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + H+/in + K+/out | Ovis aries | - |
ADP + phosphate + H+/out + K+/in | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| stomach | mucosa | Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + H+/in + K+/out | - |
Ovis aries | ADP + phosphate + H+/out + K+/in | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gastric H+,K+-ATPase | - |
Ovis aries |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Ovis aries |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Ovis aries |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
pH 6.5, 37°C | Ovis aries | ginger hydrolysed phenolic fraction | |
| 0.0027 | - |
pH 6.5, 37°C | Ovis aries | caffeic acid | |
| 0.0029 | - |
pH 6.5, 37°C | Ovis aries | ginger-free phenolic fraction | |
| 0.015 | - |
pH 6.5, 37°C | Ovis aries | Cinnamic acid | |
| 0.0193 | - |
pH 6.5, 37°C | Ovis aries | lansoprazole | |
| 0.034 | - |
pH 6.5, 37°C | Ovis aries | ferulic acid | |
| 0.037 | - |
pH 6.5, 37°C | Ovis aries | syringic acid | |
| 0.04 | - |
pH 6.5, 37°C | Ovis aries | 4-coumaric acid | |
| 0.047 | - |
pH 6.5, 37°C | Ovis aries | protocatechuic acid | |
| 0.059 | - |
pH 6.5, 37°C | Ovis aries | gentisic acid | |
| 0.132 | - |
pH 6.5, 37°C | Ovis aries | gallic acid | |
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