Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-coumaric acid | - |
Ovis aries | |
caffeic acid | - |
Ovis aries | |
Cinnamic acid | - |
Ovis aries | |
ferulic acid | - |
Ovis aries | |
gallic acid | - |
Ovis aries | |
gentisic acid | - |
Ovis aries | |
ginger hydrolysed phenolic fraction | of ginger, Zingiber officinale, rhizome, constituted by cinnamic (48%), 4-coumaric (34%) and caffeic (6%) acids as major phenolic acids, as potent inhibitors of gastric cell proton potassium ATPase activity and Helicobacter pylori growth, exhibiting strong antioxidant potency, overview | Ovis aries | |
ginger-free phenolic fraction | the fraction is constituted by syringic (38%), gallic (18%) and cinnamic (14%) acids, as potent inhibitors of gastric cell proton potassium ATPase activity and Helicobacter pylori growth, exhibiting strong antioxidant potency, overview | Ovis aries | |
lansoprazole | - |
Ovis aries | |
additional information | determination of minimal inhibitory concentration, MIC, values | Ovis aries | |
protocatechuic acid | - |
Ovis aries | |
syringic acid | - |
Ovis aries |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Ovis aries | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | Ovis aries | - |
ADP + phosphate + H+/out + K+/in | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
stomach | mucosa | Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | - |
Ovis aries | ADP + phosphate + H+/out + K+/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gastric H+,K+-ATPase | - |
Ovis aries |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Ovis aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Ovis aries |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0015 | - |
pH 6.5, 37°C | Ovis aries | ginger hydrolysed phenolic fraction | |
0.0027 | - |
pH 6.5, 37°C | Ovis aries | caffeic acid | |
0.0029 | - |
pH 6.5, 37°C | Ovis aries | ginger-free phenolic fraction | |
0.015 | - |
pH 6.5, 37°C | Ovis aries | Cinnamic acid | |
0.0193 | - |
pH 6.5, 37°C | Ovis aries | lansoprazole | |
0.034 | - |
pH 6.5, 37°C | Ovis aries | ferulic acid | |
0.037 | - |
pH 6.5, 37°C | Ovis aries | syringic acid | |
0.04 | - |
pH 6.5, 37°C | Ovis aries | 4-coumaric acid | |
0.047 | - |
pH 6.5, 37°C | Ovis aries | protocatechuic acid | |
0.059 | - |
pH 6.5, 37°C | Ovis aries | gentisic acid | |
0.132 | - |
pH 6.5, 37°C | Ovis aries | gallic acid |