EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
7.2.2.19 | 0.000077 |
- |
(7R,8R,9R)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol |
wild type enzyme, at pH 7.6 and 37°C |
752229 |
7.2.2.19 | 0.00017 |
- |
strophanthidin |
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C |
700594 |
7.2.2.19 | 0.00031 |
- |
Ouabain |
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C |
700594 |
7.2.2.19 | 0.00041 |
- |
SCH28080 |
IC50: 0.00041 mM for wild-type enzyme |
654331 |
7.2.2.19 | 0.00075 |
- |
digoxigenin |
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C |
700594 |
7.2.2.19 | 0.00076 |
- |
digoxin |
pH 7.0, 37°C, mutant D312E/S319G/A778P/I795L/F802C |
700594 |
7.2.2.19 | 0.0008 |
- |
vanadate |
pH 7.0, 37°C, recombinant enzyme, in presence of 100 mM Na+ |
685328 |
7.2.2.19 | 0.0011 |
- |
SCH28080 |
at pH 7.6 and 37°C |
752229 |
7.2.2.19 | 0.0013 |
- |
vanadate |
pH 7.0, 37°C, recombinant enzyme, in presence of 10 mM NH4+ |
685328 |
7.2.2.19 | 0.0015 |
- |
ginger hydrolysed phenolic fraction |
pH 6.5, 37°C |
689063 |