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7.2.2.19: H+/K+-exchanging ATPase

This is an abbreviated version!
For detailed information about H+/K+-exchanging ATPase, go to the full flat file.

Word Map on EC 7.2.2.19

Reaction

ATP
+
H2O
 +
H+[side 1]
 +
K+[side 2]
=
ADP
 +
phosphate
 +
H+[side 2]
 +
K+[side 1]

Synonyms

(H++K+)-ATPase, Atp12a, ATP1al1, ATP4A, ATP4B, EC 3.6.1.36, EC 3.6.3.10, electroneutral H+/K+-ATPase, gastric (H+, K+)-ATPase, gastric H+,K+-ATPase, gastric H+/K+-ATPase, gastric H+K+-ATPase, gastric H,K-ATPase, gastric H/K-ATPase, gastric HK-ATPase, gastric proton pump, H(+),K(+)-ATPase, H+, K+-ATPase, H+,K+ ATPase, H+,K+-adenosine triphosphatase, H+,K+-ATPase, H+-K+-adenosinetriphosphatase, H+-K+-ATPase, H+-K+-ATPase alpha2, H+/K+ ATPase, H+/K+ pump, H+/K+-ATPase, H+K+-ATPase, H,K-ATPase, H-K-ATPase, HKA, HKalpha1, HKalpha2, HKbeta, More, non-gastric H+/K+ ATPase, non-gastric H+/K+ATPase, non-gastric H,K-ATPase, nongastric H+-K+-ATPase, nongastric H,K-ATPase, nongastric H-K-ATPase, ouabain-sensitive H+/K+-ATPase, Proton pump

ECTree

     7 Translocases
         7.2 Catalysing the translocation of inorganic cations
             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.2.2.19 H+/K+-exchanging ATPase

Inhibitors

Inhibitors on EC 7.2.2.19 - H+/K+-exchanging ATPase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(7R,8R,9R)-2,3,10-trimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol
-
(7R,8R,9R)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol
high-affinity K+-competitive inhibitor
(8-[(2-ethyl-6-methylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyrazin-6-yl)methanol
-
-
(CH3)4N+
-
-
(R)-(+)-[(2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
-
a K+-Cl- cotransport, KCC, inhibitor, inhibits the enzyme in intact apical canalicular membranes, not in lealy membranes, via inhibition of the K+-Cl- cotransport
1,3,5,6-tetrahydroxy-2-(3-hydroxy-3-methylbutyl)-xanthone
-
a xanthone isolated from Calophyllum brasiliense leaves
1-(2',6'-dimethylbiphenyl-3-yl)-4-methylpiperazine
-
-
1-(2',6'-dimethylbiphenyl-3-yl)-N-methylmethanamine
-
-
1-hydroxy-3,5,6-tri-O-acetyl-2(3,3-dimethyl-allyl)-xanthone
-
a xanthone isolated from Calophyllum brasiliense leaves
2-(2',6'-diethylbiphenyl-3-yl)-4,5-dimethyl-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-2-yl)-4,5-dimethyl-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-3-yl)-1,4,5-trimethyl-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-3-yl)-1-methyl-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-3-yl)-1-propyl-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-3-yl)-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-3-yl)-4,5-diethyl-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-3-yl)-4,5-dimethyl-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-3-yl)-5-phenyl-1H-imidazole
-
-
2-(2',6'-dimethylbiphenyl-3-yl)pyridin-4-amine
-
-
2-(2-methoxy-2',6'-dimethylbiphenyl-3-yl)-4,5-dimethyl-1H-imidazole
-
-
2-(4-ethoxy-2',6'-dimethylbiphenyl-3-yl)-4,5-dimethyl-1H-imidazole
-
-
2-(4-methoxy-2',6'-dimethylbiphenyl-3-yl)-4,5-dimethyl-1-propyl-1H-imidazole
-
-
2-(4-methoxy-2',6'-dimethylbiphenyl-3-yl)-4,5-dimethyl-1H-imidazole
-
-
2-(6-methoxy-2',6'-dimethylbiphenyl-3-yl)-4,5-dimethyl-1H-imidazole
-
-
2-(biphenyl-3-yl)-4,5-dimethyl-1H-imidazole
-
-
2-(biphenyl-4-yl)-4,5-dimethyl-1H-imidazole
-
-
2-aminopyrazine
-
-
2-Methoxy-2,4-diphenyl-3-dihydrofuranone
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
2-phenyl-6,7-dihydrobenzofuran-4(5H)-one oxime
-
-
2-[(4-[4-[4-(azidomethyl)phenoxy]butoxy]-3-methylpyridin-2-yl)methanesulfinyl]-1H-benzimidazole
inhibits ATPase activity by approximately 50% at 0.01 mM
2-[4-(2,6-dimethylphenyl)furan-2-yl]-4,5-dimethyl-1H-imidazole
-
-
2-[4-(2,6-dimethylphenyl)thiophen-2-yl]-4,5-dimethyl-1H-imidazole
-
-
2-[4-(benzyloxy)-2',6'-dimethylbiphenyl-3-yl]-4,5-dimethyl-1H-imidazole
-
-
2-[4-(difluoromethoxy)-2',6'-dimethylbiphenyl-3-yl]-4,5-dimethyl-1H-imidazole
-
-
2-[5-(2,6-dimethylphenyl)-1-benzofuran-7-yl]-4,5-dimethyl-1H-imidazole
-
-
2-[5-(2,6-dimethylphenyl)-2,3-dihydro-1-benzofuran-7-yl]-4,5-dimethyl-1H-imidazole
-
-
2-[5-(2,6-dimethylphenyl)furan-2-yl]-4,5-dimethyl-1H-imidazole
-
-
2-[5-(2,6-dimethylphenyl)thiophen-2-yl]-4,5-dimethyl-1H-imidazole
-
-
2-{[3-(4,5-dimethyl-1H-imidazol-2-yl)-2',6'-dimethylbiphenyl-4-yl]oxy}acetamide
-
-
3'-(4,5-dimethyl-1H-imidazol-2-yl)-3-methylbiphenyl-4-thiol
-
-
3-(4,5-dimethyl-1H-imidazol-2-yl)-2',6'-dimethylbiphenyl-4-ol
-
-
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5-trihydroxybenzylidene)propanehydrazide
-
-
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5trimethoxybenzylidene)propanehydrazide
-
-
3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
-
3-({[3-(4,5-dimethyl-1H-imidazol-2-yl)-2',6'-dimethylbiphenyl-4-yl]oxy}methyl)pyridine
-
-
4,5-dimethyl-2-(2',4,5,6'-tetramethylbiphenyl-3-yl)-1H-imidazole
-
-
-
4,5-dimethyl-2-(2',6,6'-trimethylbiphenyl-3-yl)-1H-imidazole
-
-
4,5-dimethyl-2-(2'-methylbiphenyl-3-yl)-1H-imidazole
-
-
4,5-dimethyl-2-[3-(2-phenylethenyl)phenyl]-1H-imidazole
-
-
4,5-dimethyl-2-[3-(2-phenylethyl)phenyl]-1H-imidazole
-
-
4-(2',6'-dimethylbiphenyl-3-yl)-1,2-dimethyl-1H-imidazole
-
-
4-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'(3,4,5trimethoxybenzylidene)butanehydrazide
-
-
4-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5-trihydroxybenzylidene)butanehydrazide
-
-
4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
4-([2-[(1H-benzimidazole-2-sulfinyl)methyl]-3-methylpyridin-4-yl]oxy)butyl [4-(1,2,4,5-tetrazin-3-yl)phenyl]acetate
inhibits ATPase activity by approximately 50% at 0.01 mM
4-coumaric acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
5-(2',6'-dimethylbiphenyl-3-yl)-1-methyl-1H-imidazole
-
-
6-desoxyjacareubin
-
a xanthone isolated from Calophyllum brasiliense leaves
8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine
-
8-[(2-ethyl-6-methylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide
-
-
8-[(2-ethyl-6-methylbenzyl)amino]-N,2,3-trimethylimidazo[1,2-a]pyrazine-6-carboxamide
-
-
8-[(2-ethyl-6-methylbenzyl)amino]-N,N,2,3-tetramethylimidazo[1,2-a]pyrazine-6-carboxamide
-
-
8-[(2-ethyl-6-methylbenzyl)amino]-N-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide
-
-
8-[(2-ethyl-6-methylbenzyl)amino]-N-(2-methoxyethyl)-2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide
-
-
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
-
-
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-N,2,3-trimethylimidazo[1,2-a]pyridine-6-carboxamide
-
-
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-N,N,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide
-
-
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-N-(1-methoxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
-
-
8-[[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]oxy]-N,N,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide
-
-
8-[[(1S,2S)-2-hydroxy-7-methoxy-2,3-dihydro-1H-inden-1-yl]oxy]-N,N,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide
-
-
8-[[(1S,2S)-2-hydroxy-7-methyl-2,3-dihydro-1H-inden-1-yl]oxy]-N,N,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide
-
-
aluminum fluoride
antibody 2G11
-
-
-
AR-HO47108
-
-
ATP
-
ATP concentrations over 5 mM induce H+/K+-ATPase activity inhibition, suggesting the existence of ATP-regulatory sites
beryllium fluoride
irreversible inhibition by the fluorinated phosphate analogue, activity is not restored by divalent cations, e.g. Mg2+. Electronmicrospoic structure of BeF-bound H+,K+-ATPase at 8 A resolution, and structural comparison of H+,K+-ATPase in the E2BeF and E2AlF states, overview
BMT-1
-
i.e. 2-(1H-benzimidazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
bufalin
-
-
Butanedione
BYK36399
BYK73
i.e. (7R,8R,9R)-2,3,10-trimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol
BYK99
i.e. (7R,8R,9R)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol, high-affinity K+-competitive inhibitor
caffeic acid
-
-
Cd2+
-
-
Cinnamic acid
-
-
clotrimazole
-
molecular mechanism of the inhibitory effect is studied by steady-state fluorescence experiments with the electrochromic styryl dye RH421
Cu2+
-
-
diclofenac
-
-
diethyldicarbonate
digitoxin
-
-
digoxigenin
-
inhibition of mutant D312E/S319G/A778P/I795L/F802C, not of the wild-type enzyme
digoxin
dihydro-ouabain
-
inhibition of mutant D312E/S319G/A778P/I795L/F802C, not of the wild-type enzyme
Dipicrylamine
esomeprazole
ethyl 2-ethoxyquinoline-1(2H)-carboxylate
ferulic acid
-
-
Fluorescein 5'-isothiocyanate
-
fluorescein 5'-isothiocyanate modified enzyme has 0.5-1.5% residual ATPase activity compared to the unmodified enzyme
gallic acid
-
-
gentisic acid
-
-
ginger hydrolysed phenolic fraction
-
of ginger, Zingiber officinale, rhizome, constituted by cinnamic (48%), 4-coumaric (34%) and caffeic (6%) acids as major phenolic acids, as potent inhibitors of gastric cell proton potassium ATPase activity and Helicobacter pylori growth, exhibiting strong antioxidant potency, overview
-
ginger-free phenolic fraction
-
the fraction is constituted by syringic (38%), gallic (18%) and cinnamic (14%) acids, as potent inhibitors of gastric cell proton potassium ATPase activity and Helicobacter pylori growth, exhibiting strong antioxidant potency, overview
-
imidazopyridine
-
-
jacareubin
-
a xanthone isolated from Calophyllum brasiliense leaves
K+
-
activates, required. But in the presence of 200m M KCl, ion binding sites are more than 99% saturated with K+. The enzyme activity under this condition is near zero
lansoprazole
Li+
-
-
lonchocarpin
-
a chalcone isolated from Lonchocarpus guatemalensis roots
luteolin
magnesium fluoride
reversible inhibition by the fluorinated phosphate analogue, activity is restored by divalent cations, e.g. Mg2+
mammea A/BA
-
a coumarin isolated from Calophyllum brasiliense leaves
mammea C/OA
-
a coumarin isolated from Calophyllum brasiliense leaves
methyl {[3-(4,5-dimethyl-1H-imidazol-2-yl)-2',6'-dimethylbiphenyl-4-yl]oxy}acetate
-
-
minimiflorin
-
a flavonoid isolated from Lonchocarpus oaxacensis roots
Mn2+
-
in presence of Mg2+
mundulin
-
a flavonoid isolated from Lonchocarpus oaxacensis roots
N'-(2,3-dibromobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
-
N'-(2,3-dibromobenzyliden)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-(2,4-dichlorobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
-
N'-(2,4-dichlorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-(2,4-difluorobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
-
N'-(2,4-difluorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-(2-chloro-6-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)butane hydrazide
-
-
N'-(2-chloro-6-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
-
N'-(2-fluoro-5-nitrobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
-
N'-(2-fluoro-5-nitrobenzyliden)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-(3,4-dihydroxy-5-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
-
N'-(3,4-dihydroxy-5-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-(4-chlorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
-
N'-(4-chlorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-(4-hydroxy-3-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
-
N'-(4-hydroxy-3-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl) butanehydrazide
-
-
N'-(4-hydroxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
-
N'-(4-hydroxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-(4-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
-
N'-(4-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-(4-nitrobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
-
N'-(4-nitrobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N'-benzylidene-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
-
N'-benzylidene-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
-
N,N'-dicyclohexylcarbodiimide
N-(2,6-dimethylbenzyl)-3-(4,5-dimethyl-1H-imidazol-2-yl)aniline
-
-
N-(2-ethyl-6-methylbenzyl)-2,3-dimethyl-6-(pyrrolidin-1-ylcarbonyl)imidazo[1,2-a]pyrazin-8-amine
-
-
N-(2-ethyl-6-methylbenzyl)-6-(methoxymethyl)-2,3-dimethylimidazo[1,2-a]pyrazin-8-amine
-
-
N-(4-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)butane hydrazide
-
-
N-(4-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
-
N-methyl-BYK36399
N-[3-(4,5-dimethyl-1H-imidazol-2-yl)phenyl]-2,6-dimethylaniline
-
-
N-[3-(4,5-dimethyl-1H-imidazol-2-yl)phenyl]benzamide
-
-
oligomycin
Omeprazole
ouabagenin
-
inhibition of mutant D312E/S319G/A778P/I795L/F802C, not of the wild-type enzyme
Ouabain
oubain
P-CAB1
-
-
p-chloromercuribenzene sulfonate
pantoprazole
potato galactan polysaccharide
-
potent inhibitory activity with an IC50 value of 0.42 mg/ml in vitro
-
proscillaridin A
-
-
protocatechuic acid
-
-
rabeprazole
SCH 28080
SCH 32651
-
-
SCH-CN-
i.e. 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine
SCH-Me-
i.e. [8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl]acetonitrile
SCH28080
Sr2+
-
-
strophanthidin
-
inhibition of mutant D312E/S319G/A778P/I795L/F802C, not of the wild-type enzyme
syringic acid
-
-
timoprazole
trimethyltin chloride
-
i.e. TMT, trimethyltin chloride directly inhibits the activity of H+/K+-ATPases in renal intercalated cells reducing urine K+ reabsorption and inducing hypokalemia. It increases potassium leakage from the kidney, raises urine pH, and inhibits H+/K+-ATPase activity both in vitro and in vivo. In toxicated rats, H+/K+-ATPase activity is positively correlated with the decrease of plasma K+ and blood pH but is negatively correlated with the increase of urine K+ and urine pH, while trimethyltin chloride does not change the expression of H+/K+-ATPase protein and mRNA
Trypsin
-
vanadate
[(dihydroindenyl)oxy]acetic acid
-
DIOA
[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]acetonitrile
-
[8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl]acetonitrile
-
additional information
-