Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.19 extracted from

  • Rulli, S.J.; Louneva, N.M.; Skripnikova, E.V.; Rabon, E.C.
    Site-directed mutagenesis of cation coordinating residues in the gastric H,K-ATPase (2001), Arch. Biochem. Biophys., 387, 27-34.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E774A IC50 for SCH28080 is 2.2fold higher than that of the wild-type enzyme Oryctolagus cuniculus
E774Q IC50 for SCH28080 is nearly identical to that of the wild-type enzyme Oryctolagus cuniculus
E797Q IC50 for SCH28080 is 4.3fold higher than that of the wild-type enzyme Oryctolagus cuniculus
E938A IC50 for SCH28080 is 8.2fold lower than that of the wild-type enzyme Oryctolagus cuniculus
E938Q IC50 for SCH28080 is 1.6fold higher than that of the wild-type enzyme Oryctolagus cuniculus
T825A IC50 for SCH28080 is nearly identical to that of the wild-type enzyme Oryctolagus cuniculus
T825L IC50 for SCH28080 is 4.5fold lower than that of the wild-type enzyme Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
SCH28080 IC50: 0.00041 for wild-type enzyme Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
94000
-
x * 94000 (alpha) + x * ? (beta), SDS-PAGE Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P18597 beta-subunit
-
Oryctolagus cuniculus P27112 alpha-subunit
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in + K+/out
-
Oryctolagus cuniculus ADP + phosphate + H+/out + K+/in
-
?

Subunits

Subunits Comment Organism
? x * 94000 (alpha) + x * ? (beta), SDS-PAGE Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
gastric (H+, K+)-ATPase
-
Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00041
-
IC50: 0.00041 mM for wild-type enzyme Oryctolagus cuniculus SCH28080