Protein Variants | Comment | Organism |
---|---|---|
E774A | IC50 for SCH28080 is 2.2fold higher than that of the wild-type enzyme | Oryctolagus cuniculus |
E774Q | IC50 for SCH28080 is nearly identical to that of the wild-type enzyme | Oryctolagus cuniculus |
E797Q | IC50 for SCH28080 is 4.3fold higher than that of the wild-type enzyme | Oryctolagus cuniculus |
E938A | IC50 for SCH28080 is 8.2fold lower than that of the wild-type enzyme | Oryctolagus cuniculus |
E938Q | IC50 for SCH28080 is 1.6fold higher than that of the wild-type enzyme | Oryctolagus cuniculus |
T825A | IC50 for SCH28080 is nearly identical to that of the wild-type enzyme | Oryctolagus cuniculus |
T825L | IC50 for SCH28080 is 4.5fold lower than that of the wild-type enzyme | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SCH28080 | IC50: 0.00041 for wild-type enzyme | Oryctolagus cuniculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
94000 | - |
x * 94000 (alpha) + x * ? (beta), SDS-PAGE | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P18597 | beta-subunit | - |
Oryctolagus cuniculus | P27112 | alpha-subunit | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric mucosa | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | - |
Oryctolagus cuniculus | ADP + phosphate + H+/out + K+/in | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 94000 (alpha) + x * ? (beta), SDS-PAGE | Oryctolagus cuniculus |
Synonyms | Comment | Organism |
---|---|---|
gastric (H+, K+)-ATPase | - |
Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00041 | - |
IC50: 0.00041 mM for wild-type enzyme | Oryctolagus cuniculus | SCH28080 |