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Literature summary for 7.2.2.19 extracted from

  • Reyes-Chilpa, R.; Baggio, C.H.; Alavez-Solano, D.; Estrada-Muniz, E.; Kauffman, F.C.; Sanchez, R.I.; Mesia-Vela, S.
    Inhibition of gastric H+,K+-ATPase activity by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants (2006), J. Ethnopharmacol., 105, 167-172.
    View publication on PubMed
Search for more literature for 7.2.2.19

Inhibitors

Inhibitors Comment Organism Structure
1,3,5,6-tetrahydroxy-2-(3-hydroxy-3-methylbutyl)-xanthone a xanthone isolated from Calophyllum brasiliense leaves Canis lupus familiaris
1-hydroxy-3,5,6-tri-O-acetyl-2(3,3-dimethyl-allyl)-xanthone a xanthone isolated from Calophyllum brasiliense leaves Canis lupus familiaris
6-desoxyjacareubin a xanthone isolated from Calophyllum brasiliense leaves Canis lupus familiaris
jacareubin a xanthone isolated from Calophyllum brasiliense leaves Canis lupus familiaris
lonchocarpin a chalcone isolated from Lonchocarpus guatemalensis roots Canis lupus familiaris
mammea A/BA a coumarin isolated from Calophyllum brasiliense leaves Canis lupus familiaris
mammea C/OA a coumarin isolated from Calophyllum brasiliense leaves Canis lupus familiaris
minimiflorin a flavonoid isolated from Lonchocarpus oaxacensis roots Canis lupus familiaris
mundulin a flavonoid isolated from Lonchocarpus oaxacensis roots Canis lupus familiaris
Omeprazole
-
 Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Canis lupus familiaris 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in + K+/out Canis lupus familiaris
-
 ADP + phosphate + H+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
stomach mucosa Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in + K+/out
-
 Canis lupus familiaris ADP + phosphate + H+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
gastric H+,K+-ATPase
-
 Canis lupus familiaris

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Canis lupus familiaris

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0096
-
 pH 7.4, 37°C Canis lupus familiaris minimiflorin
0.0467
-
 pH 7.4, 37°C Canis lupus familiaris jacareubin
0.07
-
 pH 7.4, 37°C Canis lupus familiaris mundulin
0.1095
-
 pH 7.4, 37°C Canis lupus familiaris mammea A/BA
0.171
-
 pH 7.4, 37°C Canis lupus familiaris (2E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-phenylprop-2-en-1-one
0.173
-
 pH 7.4, 37°C Canis lupus familiaris 1,3,5,6-tetrahydroxy-2-(3-hydroxy-3-methylbutyl)-xanthone
0.41
-
 pH 7.4, 37°C Canis lupus familiaris Omeprazole
0.638
-
 pH 7.4, 37°C Canis lupus familiaris mammea C/OA
1.581
-
 pH 7.4, 37°C Canis lupus familiaris 6-desoxyjacareubin
1.605
-
 pH 7.4, 37°C Canis lupus familiaris 1-hydroxy-3,5,6-tri-O-acetyl-2(3,3-dimethyl-allyl)-xanthone