BRENDA - Enzyme Database
show all sequences of 7.2.2.19

H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry

Aw, S.; Adams, D.S.; Qiu, D.; Levin, M.; Mech. Dev. 125, 353-372 (2008)

Data extracted from this reference:

Engineering
Protein Variants
Commentary
Organism
additional information
a LacZ fusion enzyme fused to motor proteins reveals endogenous polarity in the cytoplasmic transport machinery, overview
Gallus gallus
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
H+/K+-ATPase inhibition does not affect Cx43 expression in chicken
Gallus gallus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoskeleton
H+/K+-ATPase localization along two axes is dependent on intracellular transport machinery, overview
Gallus gallus
5856
-
cytoskeleton
H+/K+-ATPase localization along two axes is dependent on intracellular transport machinery, overview
Xenopus laevis
5856
-
membrane
-
Gallus gallus
16020
-
membrane
-
Xenopus laevis
16020
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + H2O + H+/in + K+/out
Xenopus laevis
the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview
ADP + phosphate + H+/out + K+/in
-
-
?
ATP + H2O + H+/in + K+/out
Gallus gallus
the known requirement for H+/K+-ATPase function in chick asymmetry does not function through effects on the circumferential expression pattern of Connexin43, physiological function, overview
ADP + phosphate + H+/out + K+/in
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Gallus gallus
-
-
-
Xenopus laevis
-
-
-
Reaction
Reaction
Commentary
Organism
Reaction ID
ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1]
mechanistic modeling of the physiological events linking subcellular processes to largescale patterning involving the enzyme
Gallus gallus
ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1]
mechanistic modeling of the physiological events linking subcellular processes to largescale patterning involving the enzyme
Xenopus laevis
Source Tissue
Source Tissue
Commentary
Organism
Textmining
embryo
-
Xenopus laevis
-
embryo
H+/K+-ATPase and Kir4.1 are expressed in the primitive streak
Gallus gallus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ATP + H2O + H+/in + K+/out
-
688799
Gallus gallus
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
-
688799
Xenopus laevis
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview
688799
Xenopus laevis
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
the known requirement for H+/K+-ATPase function in chick asymmetry does not function through effects on the circumferential expression pattern of Connexin43, physiological function, overview
688799
Gallus gallus
ADP + phosphate + H+/out + K+/in
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
electroneutral H+/K+-ATPase
-
Gallus gallus
electroneutral H+/K+-ATPase
-
Xenopus laevis
H+/K+-ATPase
-
Gallus gallus
H+/K+-ATPase
-
Xenopus laevis
H,K-ATPase
-
Gallus gallus
H,K-ATPase
-
Xenopus laevis
Engineering (protein specific)
Protein Variants
Commentary
Organism
additional information
a LacZ fusion enzyme fused to motor proteins reveals endogenous polarity in the cytoplasmic transport machinery, overview
Gallus gallus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
H+/K+-ATPase inhibition does not affect Cx43 expression in chicken
Gallus gallus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoskeleton
H+/K+-ATPase localization along two axes is dependent on intracellular transport machinery, overview
Gallus gallus
5856
-
cytoskeleton
H+/K+-ATPase localization along two axes is dependent on intracellular transport machinery, overview
Xenopus laevis
5856
-
membrane
-
Gallus gallus
16020
-
membrane
-
Xenopus laevis
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + H2O + H+/in + K+/out
Xenopus laevis
the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview
ADP + phosphate + H+/out + K+/in
-
-
?
ATP + H2O + H+/in + K+/out
Gallus gallus
the known requirement for H+/K+-ATPase function in chick asymmetry does not function through effects on the circumferential expression pattern of Connexin43, physiological function, overview
ADP + phosphate + H+/out + K+/in
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
embryo
-
Xenopus laevis
-
embryo
H+/K+-ATPase and Kir4.1 are expressed in the primitive streak
Gallus gallus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ATP + H2O + H+/in + K+/out
-
688799
Gallus gallus
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
-
688799
Xenopus laevis
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview
688799
Xenopus laevis
ADP + phosphate + H+/out + K+/in
-
-
-
?
ATP + H2O + H+/in + K+/out
the known requirement for H+/K+-ATPase function in chick asymmetry does not function through effects on the circumferential expression pattern of Connexin43, physiological function, overview
688799
Gallus gallus
ADP + phosphate + H+/out + K+/in
-
-
-
?
Other publictions for EC 7.2.2.19
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750685
Xian
Phenylalanine and tryptophan ...
Sus scrofa
Gen. Comp. Endocrinol.
267
1-8
2018
2
-
-
-
-
-
-
-
-
-
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1
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10
-
-
-
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3
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1
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1
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1
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3
-
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1
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-
-
-
-
-
-
-
-
752233
Dubey
K+ binding and proton redistr ...
Sus scrofa
Sci. Rep.
8
12732
2018
-
-
1
-
7
-
1
3
1
1
-
1
-
1
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-
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-
1
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1
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2
-
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1
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7
-
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1
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3
1
1
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1
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1
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1
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-
-
-
-
-
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-
-
-
-
-
-
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-
751358
Jana
Designed inhibitors with hete ...
Sus scrofa
J. Mol. Graph. Model.
78
129-138
2017
-
-
-
-
-
-
1
-
-
-
-
1
-
1
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-
-
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1
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1
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1
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1
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1
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1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752229
Abe
The cryo-EM structure of gast ...
Sus scrofa
Sci. Rep.
7
6632
2017
-
-
1
-
22
-
10
-
-
-
-
1
-
3
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
10
-
6
-
-
1
-
-
22
-
6
10
10
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
750018
Rakesh
Synthesis and SAR studies of ...
Ovis aries
Bioorg. Chem.
68
1-8
2016
-
-
-
-
-
-
33
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
32
-
-
-
-
-
-
-
32
33
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
750207
Miyazaki
The gastric H,K-ATPase in str ...
Mus musculus
BMC Physiol.
17
1-1
2016
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
2
-
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-
-
-
-
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1
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1
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-
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
750826
Badanavalu Chandrashekar
Gastro protective and H+, K+- ...
Ovis aries
Int. J. Biol. Macromol.
84
385-393
2016
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
1
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2
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1
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-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
751533
Paresi
Benzimidazole covalent probes ...
Sus scrofa
Mol. Biosyst.
12
1772-1780
2016
-
-
-
-
-
-
3
-
-
1
1
1
-
1
-
-
-
-
-
2
-
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1
1
2
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3
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1
1
1
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-
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2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733694
Schatzberg
H+/K+ ATPase activity is requi ...
Lytechinus variegatus
Dev. Biol.
406
259-270
2015
-
-
-
-
-
-
1
-
-
-
-
1
-
1
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1
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1
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2
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1
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1
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1
-
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1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
733915
Ip
Light induces changes in activ ...
Tridacna squamosa
Front. Physiol.
6
68
2015
-
-
-
-
-
-
1
-
-
3
-
1
-
1
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2
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1
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2
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1
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3
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1
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-
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2
-
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1
-
-
-
-
-
-
-
-
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3
-
-
3
-
-
735021
Wang
Proton pump inhibitors inhibit ...
Homo sapiens
PLoS ONE
10
e0126432
2015
-
-
-
-
-
-
2
-
-
-
3
1
-
1
-
1
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-
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2
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1
3
5
-
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2
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1
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1
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2
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1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
750421
Feng
-
K+ Uptake, H+-ATPase pumping ...
Hordeum vulgare
Environ. Exp. Bot.
129
57-66
2015
-
-
-
-
-
-
-
-
-
-
-
1
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1
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1
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1
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1
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1
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-
-
-
-
-
-
-
1
1
1
1
-
-
734279
Abe
Systematic comparison of molec ...
Sus scrofa
J. Biol. Chem.
289
30590-30601
2014
-
-
-
-
1
-
1
-
1
-
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1
-
2
-
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1
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1
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1
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1
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1
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1
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1
-
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-
-
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734286
Yu
Spatial control of proton pump ...
Oryctolagus cuniculus
J. Biol. Chem.
289
33333-33342
2014
-
-
-
-
-
-
-
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1
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1
1
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3
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2
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1
1
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1
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2
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1
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734742
Liu
2-(1H-benzimidazol-2-yl)-4,5,6 ...
Homo sapiens
Molecules
19
17173-17186
2014
-
-
-
-
-
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1
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1
1
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1
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733051
Fang
-
Synthesis and H+/K+-ATPase inh ...
Homo sapiens
AIDS Res. Hum. Retroviruses
634-638
1192-1195
2013
-
-
-
-
-
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2
-
-
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1
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1
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1
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1
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1
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734202
Dach
Active detergent-solubilized H ...
Sus scrofa
J. Biol. Chem.
287
41963-41978
2012
-
-
-
-
-
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1
-
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1
1
-
4
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1
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1
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1
1
1
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1
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1
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1
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1
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1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735047
Duerr
Control of gastric H,K-ATPase ...
Rattus norvegicus
PLoS ONE
7
e33645
2012
-
-
1
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1
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-
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1
-
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1
-
4
-
-
-
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2
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1
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1
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1
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1
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2
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1
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-
-
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735163
Abe
Cryo-EM structure of gastric H ...
Sus scrofa
Proc. Natl. Acad. Sci. USA
109
18401-18406
2012
-
-
-
-
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1
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1
1
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1
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1
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1
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1
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1
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Inhibition of the gastric H,K- ...
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Discovery of biaryl inhibitors ...
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Tang
Mechanism underlying hypokalem ...
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Yu
Sp1 trans-activates the murine ...
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Cyclo-oxygenase-1 inhibition i ...
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1
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Vesper
The effect of proton pump inhi ...
Homo sapiens
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Duerr
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1
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1
1
1
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1
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1
1
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2
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1
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1
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1
1
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1
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Fujii
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1
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2
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700593
Shin
The gastric HK-ATPase: structu ...
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609-622
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15
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10
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15
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15
10
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De Pont
The non-gastric H,K-ATPase as ...
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623-634
2009
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Duerr
Characterization of Na,K-ATPas ...
Rattus norvegicus
Biochemistry
47
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2008
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Zimmermann
Novel imidazo[1,2-a]pyrazine d ...
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11
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Morii
Involvement of the H3O+-Lys-16 ...
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2
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Nishizawa
Structural analysis of 2D crys ...
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1
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1
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1
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1
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1
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688799
Aw
H,K-ATPase protein localizatio ...
Gallus gallus, Xenopus laevis
Mech. Dev.
125
353-372
2008
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4
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Zavros
Sonic hedgehog is associated w ...
Oryctolagus cuniculus
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295
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3
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1
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Law
An ion gating mechanism of gas ...
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1
1
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1
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1
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1
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697225
Morokuma
KCNQ1 and KCNE1 K+ channel com ...
Xenopus laevis
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21
357-372
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1
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1
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3
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-
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Freitas
Inhibition of H+/K+ ATPase in ...
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60
1105-1110
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1
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4
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2
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2
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2
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2
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2
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5
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2
2
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4
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3
1
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4
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2
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2
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685080
Reenstra
The conformation of H,K-ATPase ...
Sus scrofa
Biochemistry
46
10145-10152
2007
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1
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1
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3
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2
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1
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1
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685328
Swarts
The human non-gastric H,K-ATPa ...
Homo sapiens
Biochim. Biophys. Acta
1768
580-589
2007
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1
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685586
Zimmermann
Novel indanyl-substituted imid ...
Sus scrofa
Bioorg. Med. Chem. Lett.
17
5374-5378
2007
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8
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8
10
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Fujii
Inhibition of P-type ATPases b ...
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Siddaraju
Inhibition of gastric H+,K+-AT ...
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Pestov
Loss of acidification of anter ...
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Molecular regulation and physi ...
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Electrogenic partial reactions ...
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Evidence for a relationship be ...
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Purification of Na+,K+-ATPase ...
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Shin
Differences in binding propert ...
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Pestov
Identification of the b-subuni ...
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A putative H+-K+-ATPase in the ...
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Ivanov
Evaluation of the ordering of ...
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Koenderink
A conformation-specific interh ...
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Sawaguchi
High-pressure freezing of isol ...
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675723
Li
The carboxy terminus of the co ...
Rattus norvegicus
Kidney Int.
65
1301-1310
2004
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1
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1
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675724
Li
The effect of beta-subunit ass ...
Rattus norvegicus
Kidney Int.
66
1068-1075
2004
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1
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1
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1
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1
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1
1
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1
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676393
Johansson
Non-Gastric H+/K+ATPase is pre ...
Homo sapiens
Placenta
25
505-511
2004
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1
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5
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654149
Beisvag
Identification and regulation ...
Rattus norvegicus
Acta Physiol. Scand.
179
251-262
2003
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1
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3
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1
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654198
Modyanov
Nongastric H,K-ATPase: structu ...
Homo sapiens
Ann. N. Y. Acad. Sci.
986
183-187
2003
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5
1
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1
1
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654169
Crambert
Human nongastric H+-K+-ATPase: ...
Homo sapiens
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283
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2002
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1
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1
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2
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2
1
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654624
Vagin
SCH28080, a K+-competitive inh ...
Oryctolagus cuniculus
Biochemistry
41
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2002
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35
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35
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36
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656051
Kimura
Mutational study on the roles ...
Oryctolagus cuniculus
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277
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14
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1
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1
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1
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14
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1
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654173
Kraut
Detection and localization of ...
Homo sapiens
Am. J. Physiol. Renal. Physiol.
281
F763-768
2001
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4
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654331
Rulli
Site-directed mutagenesis of c ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
387
27-34
2001
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7
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1
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1
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7
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1
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1
1
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654601
Adams
Catalytic function of nongastr ...
Oryctolagus cuniculus
Biochemistry
40
5765-5776
2001
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1
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3
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5
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2
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2
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2
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2
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654605
Vagin
Mutational analysis of the K+- ...
Oryctolagus cuniculus
Biochemistry
40
7480-7490
2001
1
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16
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16
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10
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246848
Lacapere
Efficient solubilization and p ...
Sus scrofa
Biochem. J.
345
239-245
2000
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246856
Grishin
Nongastric H+,K+-ATPase: Cell ...
Rhinella marina, Homo sapiens, Rattus norvegicus
Semin. Nephrol.
19
421-430
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Characterization of the beta-s ...
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Reuben
Characterization of a beta-sub ...
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Skrabanja
Transport ratios of reconstitu ...
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Lorentzon
Inhibition of (H++K+)-ATPase b ...
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Passive transport of Rb+ by ho ...
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Faller
Vanadate binding to the gastri ...
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De Pont
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