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Literature summary for 7.2.2.19 extracted from

  • Tang, X.; Yang, X.; Lai, G.; Guo, J.; Xia, L.; Wu, B.; Xie, Y.; Huang, M.; Chen, J.; Ruan, X.; Sui, G.; Ge, Y.; Zuo, W.; Zhao, N.; Zhu, G.; Zhang, J.; Li, L.; Zhou, W.
    Mechanism underlying hypokalemia induced by trimethyltin chloride: Inhibition of H+/K+-ATPase in renal intercalated cells (2010), Toxicology, 271, 45-50.
    View publication on PubMed
Search for more literature for 7.2.2.19

Inhibitors

Inhibitors Comment Organism Structure
Ba2+ is a known inhibitor of K+ channels, and completely inhibits the whole-cell currents Rattus norvegicus
additional information addition of trimethyltin chloride alters the whole-cell current and opens K+ channels in renal cells, overview Rattus norvegicus
SCH28080 H+/K+-ATPase inhibitor Rattus norvegicus
trimethyltin chloride i.e. TMT, trimethyltin chloride directly inhibits the activity of H+/K+-ATPases in renal intercalated cells reducing urine K+ reabsorption and inducing hypokalemia. It increases potassium leakage from the kidney, raises urine pH, and inhibits H+/K+-ATPase activity both in vitro and in vivo. In toxicated rats, H+/K+-ATPase activity is positively correlated with the decrease of plasma K+ and blood pH but is negatively correlated with the increase of urine K+ and urine pH, while trimethyltin chloride does not change the expression of H+/K+-ATPase protein and mRNA Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in + K+/out Rattus norvegicus
-
 ADP + phosphate + H+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain limbic system and cerebellum Rattus norvegicus
-
epithelium renal Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
renal cortex primary cell culture Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in + K+/out
-
 Rattus norvegicus ADP + phosphate + H+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
H+/K+-ATPase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.3 assay at Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus trimethyltin chloride does not change the expression of H+/K+-ATPase protein and mRNA additional information

General Information

General Information Comment Organism
additional information direct H+/K+-ATPase inhibition by trimethyltin chloride in renal intercalated cells reduces urine K+ reabsorption and induces hypokalemia, overview Rattus norvegicus