EC Number |
Natural Substrates |
---|
7.2.2.19 | ATP + H2O + H+/in + K+/out |
- |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
primary role may be in active potassium reabsorption |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
H+,K+-ATPase family of ion pumps is an essential component of the kidneys K+ and H+ transporting machinery, under normal circumstances as well as during adaption to physiological stress |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
acid-secretory role of the enzyme is coupled to K+ movement, enzyme activity is increased under conditions of chronic metabolic acidosis |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
involved in urinary acidification |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
isoform HKalpha(1) and HKalpha(4) are present in the collecting ducts of the human kidney and might contribute to H+ and K+ transport by the kidney |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
the enzyme could contribute to potassium and pH i regulation in cardiomyocytes |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
the enzyme participates in K+ absorption and H+ secretion in the renal medulla, it is highly regulated in response to acid-base and electrolyte disturbances, colonic HKalpha2 plays a role in K+ and acid-base homeostasis as well as in early growth and development, it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview |
7.2.2.19 | ATP + H2O + H+/in + K+/out |
the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview |