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Literature summary for 7.2.2.19 extracted from
- Molecular regulation and physiology of the H+,K+-ATPases in kidney (2006), Semin. Nephrol., 26, 345-351.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| regulation of colonic HKalpha2 transcription and expression, overview | Rattus norvegicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of HKalpha1-deficient and HKalpha2-deficient mice, phenotypes with deprived H+,K+-ATPase activities, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Omeprazole | inhibits HKalpha1 | Mus musculus |  |
| Omeprazole | inhibits HKalpha1 | Rattus norvegicus | |
| Ouabain | inhibits HKalpha2, but not HKalpha1 | Mus musculus | |
| Ouabain | inhibits HKalpha2, but not HKalpha1 | Rattus norvegicus | |
| SCH 28080 | inhibits HKalpha1, but not HKalpha2 | Mus musculus | |
| SCH 28080 | inhibits HKalpha1, but not HKalpha2 | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
| membrane | membrane localization and topology model of HKalpha2, overview | Rattus norvegicus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
alphabeta composition of HKalpha1 and HKalpha2, 1 * 35000, beta-subunit of HKalpha1 | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + H+/in + K+/out | Mus musculus | it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | Rattus norvegicus | the enzyme participates in K+ absorption and H+ secretion in the renal medulla, it is highly regulated in response to acid-base and electrolyte disturbances, colonic HKalpha2 plays a role in K+ and acid-base homeostasis as well as in early growth and development, it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview | ADP + phosphate + H+/out + K+/in | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
isozymes colonic HKalpha2 and gastric HKalpha1 | - |
| Rattus norvegicus | - |
isozymes colonic HKalpha2, showing 3 splicing variants, and gastric HKalpha1 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the beta-subunit of HKalpha1 is heavily glycosylated | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | colonic HKalpha2 | Mus musculus | - |
| colon | colonic HKalpha2 | Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | HKalpha1 and HKalpha2 | Mus musculus | - |
| additional information | colonic HKalpha2 splicing variant colonic HKalpha2C is upregulated in newborn rats and undetectable in adult rats | Rattus norvegicus | - |
| renal cortex | upregulation of HKalpha1 | Rattus norvegicus | - |
| renal medulla | upregulation of HKalpha2 | Rattus norvegicus | - |
| stomach | gastric HKalpha1 | Mus musculus | - |
| stomach | gastric HKalpha1 | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + H+/in + K+/out | - |
Mus musculus | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | - |
Rattus norvegicus | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview | Mus musculus | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | the enzyme participates in K+ absorption and H+ secretion in the renal medulla, it is highly regulated in response to acid-base and electrolyte disturbances, colonic HKalpha2 plays a role in K+ and acid-base homeostasis as well as in early growth and development, it is also involved in maintainance of chronic metabolic alkalosis due to upregulation in hypokalemia, regulation of colonic HKalpha2 transcription and expression, overview | Rattus norvegicus | ADP + phosphate + H+/out + K+/in | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | alphabeta composition of HKalpha1 and HKalpha2 | Mus musculus |
| dimer | alphabeta composition of HKalpha1 and HKalpha2, 1 * 35000, beta-subunit of HKalpha1 | Rattus norvegicus |
| More | beta1-Na+,K+-ATPase is the physiologic beta-subunit of colonic HKalpha2 | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| H+,K+-adenosine triphosphatase | - |
Mus musculus |
| H+,K+-adenosine triphosphatase | - |
Rattus norvegicus |
| H+,K+-ATPase | - |
Mus musculus |
| H+,K+-ATPase | - |
Rattus norvegicus |
| HKalpha1 | - |
Mus musculus |
| HKalpha1 | - |
Rattus norvegicus |
| HKalpha2 | - |
Mus musculus |
| HKalpha2 | - |
Rattus norvegicus |
| More | the enzymes belong to the X+,K+-ATPase superfamily | Mus musculus |
| More | the enzymes belong to the X+,K+-ATPase superfamily | Rattus norvegicus |
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