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3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase

This is an abbreviated version!
For detailed information about 1-alkyl-2-acetylglycerophosphocholine esterase, go to the full flat file.

Word Map on EC 3.1.1.47

Reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine
+
H2O
=
1-alkyl-sn-glycero-3-phosphocholine
 +
acetate

Synonyms

(PAF)-acetylhydrolase, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 1-alkyl-2-acetyllecithin deacetylase, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, 2-acetyl-1-alkylglycerophosphocholine esterase, acetylhydrolase, alkylacetyl-GPC:acetylhydrolase, aspirin hydrolase, blood platelet-activating factor-acetyl hydrolase, Ca2+-independent phospholipase A2, calcium-independent serine lipase Lp-PLA2, deacetylase, 1-alkyl-2-acetyllecithin, group VII PAF acetylhydrolase homolog, group VII phospholipase A2, group VIII phospholipase A2, HpPAF-AH, HSD-PLA2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 1, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 3, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 4, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 5, LDL-associated phospholipase A2, LDL-PLA(2), lipoprotein associated phospholipase A2, lipoprotein-associated phospholipase A2, lipoprotein-associated PLA2, lipoprotein-associated platelet-activating factor acetylhydrolase, lipoprotein-PLA2, Lissencephaly-1 protein, Lp-PLA2, LpPLA2, More, PAF 2-acylhydrolase, PAF acetylhydrolase, PAF acetylhydrolase I, PAF acetylhydrolase II, PAF-acetylhydrolase, PAF-acetylhydrolase II, PAF-AH, PAF-AH (II), PAF-AH alpha, PAF-AH I, PAF-AH II, PAFAH, PAFAH alpha, PAFAH1B2, PAFAH2, phosphatide 2-acylhydrolase, phospholipase A2, PLA2, PLA2G7, PLA2G7 gene, plasma lipoprotein-associated phospholipase A2, plasma PAF acetylhydrolase, plasma PAF-AH, plasma platelet - activating factor - acetylhydrolase, plasma platelet activating factor acetylhydrolase, plasma platelet activating factor-acetylhydrolase, plasma platelet-activating factor acetylhydrolase, platelet activating factor acetylhydrolase, platelet activating factor-acetyl hydrolase, platelet activating factor-acetylhydrolase, platelet-activating factor acetyl-hydrolase, platelet-activating factor acetylhadrolase, platelet-activating factor acetylhydrolase, platelet-activating factor acetylhydrolase II, platelet-activating factor acetylhydrolyase, platelet-activating factor acetylohydrolase, platelet-activating factor-acetylhydrolase, platelet-activating-factor acetylhydrolase, Plg7p, pPAF-AH, Serine dependent phospholipase A2, serum platelet-activating factor acetylhydrolase, SpV-1, SpV-2, SpV-3, SpV-4, SpV-5, type I PAF acetylhydrolase, type I platelet-activating factor acetylhydrolase, Type II platelet-activating factor-acetylhydrolase, VIIA phospholipase A2

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase

Source Tissue

Source Tissue on EC 3.1.1.47 - 1-alkyl-2-acetylglycerophosphocholine esterase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
atherogenic aorta
Manually annotated by BRENDA team
-
nonatherogenic mammary artery
Manually annotated by BRENDA team
-
melanoma cell line, implanted in syngenic C57BI/6J mice which then show reduced vascularization and growth
Manually annotated by BRENDA team
-
platelets contain the plasma type as well as the intracellular type II PAF-AH. Platelets contain high levels of the mRNA of plasma PAF-AH, whereas only a small quantity of the type II PAF-AH mRNA is detected. Platelets secrete the plasma type of platelet-activating factor acetylhydrolase primarily associated with microparticles
Manually annotated by BRENDA team
-
isozyme II, of children with meningitis
Manually annotated by BRENDA team
the greatest PAF-AH activity is detected on the day of parturition (day 0), after which its activity dramatically decreases and by day 5, the enzyme activity is less than 7% of the level at parturition
Manually annotated by BRENDA team
-
monocyte-derived cells show very low enzyme expression
Manually annotated by BRENDA team
-
isozyme in endometrium is of the plasma enzyme type, enzyme activity decreases on day 20 in pregnant cows compared to cyclic cows on the same day, which show no changes in enzyme activity level
Manually annotated by BRENDA team
-
secretion of plasma isozyme
Manually annotated by BRENDA team
-
epidermal, isozyme II, lower amount compared to sebaceous gland
Manually annotated by BRENDA team
-
Kaposi's sarcoma cell line, implanted into SCID mice which then show reduced vascularization and growth
Manually annotated by BRENDA team
-
MM6 cell
Manually annotated by BRENDA team
-
enzyme activity increases during differentiation, only monocyte-derived dendritic cells show highly reduced enzyme expression
Manually annotated by BRENDA team
-
at least 2 isozymes I and II, increased amount of isozyme I beta-subunit
Manually annotated by BRENDA team
-
at least 2 isozymes I and II
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
clonal derivative of PC12 cell line
Manually annotated by BRENDA team
-
robust expression of PLA2G7 mRNA
Manually annotated by BRENDA team
-
PAF-AH activity in the salivary gland homogenates is lower than in the saliva
Manually annotated by BRENDA team
-
PAF-AH activity in the salivary gland homogenates is lower than in the saliva
Manually annotated by BRENDA team
-
isozyme II, high amount
Manually annotated by BRENDA team
-
the activity is significantly and negatively correlated with sperm motility. Platelet-activating factor acetylhydrolase serves as a decapacitation factor
Manually annotated by BRENDA team
-
isozyme II
Manually annotated by BRENDA team
-
isozyme I activity is lower in pregnant uterus compared to the nonpregnant one
Manually annotated by BRENDA team
-
robust expression of PLA2G7 mRNA
Manually annotated by BRENDA team
additional information