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3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase

This is an abbreviated version!
For detailed information about 1-alkyl-2-acetylglycerophosphocholine esterase, go to the full flat file.

Word Map on EC 3.1.1.47

Reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine
+
H2O
=
1-alkyl-sn-glycero-3-phosphocholine
 +
acetate

Synonyms

(PAF)-acetylhydrolase, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 1-alkyl-2-acetyllecithin deacetylase, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, 2-acetyl-1-alkylglycerophosphocholine esterase, acetylhydrolase, alkylacetyl-GPC:acetylhydrolase, aspirin hydrolase, blood platelet-activating factor-acetyl hydrolase, Ca2+-independent phospholipase A2, calcium-independent serine lipase Lp-PLA2, deacetylase, 1-alkyl-2-acetyllecithin, group VII PAF acetylhydrolase homolog, group VII phospholipase A2, group VIII phospholipase A2, HpPAF-AH, HSD-PLA2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 1, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 3, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 4, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 5, LDL-associated phospholipase A2, LDL-PLA(2), lipoprotein associated phospholipase A2, lipoprotein-associated phospholipase A2, lipoprotein-associated PLA2, lipoprotein-associated platelet-activating factor acetylhydrolase, lipoprotein-PLA2, Lissencephaly-1 protein, Lp-PLA2, LpPLA2, More, PAF 2-acylhydrolase, PAF acetylhydrolase, PAF acetylhydrolase I, PAF acetylhydrolase II, PAF-acetylhydrolase, PAF-acetylhydrolase II, PAF-AH, PAF-AH (II), PAF-AH alpha, PAF-AH I, PAF-AH II, PAFAH, PAFAH alpha, PAFAH1B2, PAFAH2, phosphatide 2-acylhydrolase, phospholipase A2, PLA2, PLA2G7, PLA2G7 gene, plasma lipoprotein-associated phospholipase A2, plasma PAF acetylhydrolase, plasma PAF-AH, plasma platelet - activating factor - acetylhydrolase, plasma platelet activating factor acetylhydrolase, plasma platelet activating factor-acetylhydrolase, plasma platelet-activating factor acetylhydrolase, platelet activating factor acetylhydrolase, platelet activating factor-acetyl hydrolase, platelet activating factor-acetylhydrolase, platelet-activating factor acetyl-hydrolase, platelet-activating factor acetylhadrolase, platelet-activating factor acetylhydrolase, platelet-activating factor acetylhydrolase II, platelet-activating factor acetylhydrolyase, platelet-activating factor acetylohydrolase, platelet-activating factor-acetylhydrolase, platelet-activating-factor acetylhydrolase, Plg7p, pPAF-AH, Serine dependent phospholipase A2, serum platelet-activating factor acetylhydrolase, SpV-1, SpV-2, SpV-3, SpV-4, SpV-5, type I PAF acetylhydrolase, type I platelet-activating factor acetylhydrolase, Type II platelet-activating factor-acetylhydrolase, VIIA phospholipase A2

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase

Specific Activity

Specific Activity on EC 3.1.1.47 - 1-alkyl-2-acetylglycerophosphocholine esterase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000001
-
acetylhydrolase activity mg tissue, mammary artery, plus Pefablok
0.0000003
-
acetylhydrolase activity mg tissue, aorta, plus Pefablok
0.0000005
-
mutant S257A, substrate azelaoyl phosphatidylcholine
0.0000014
-
acetylhydrolase activity mg tissue, mammary artery
0.0000028
-
acetylhydrolase activity mg tissue, aorta
0.000008
-
cytosolic fraction, nonpregnant uterus
0.00001
-
wild type, substrate azelaoyl phosphatidylcholine
0.000012
-
PAF-AH isozyme Ib alpha2 subunit, transacetylase activity
0.000073
-
cytosolic fraction, pregnant uterine myometrium
0.000221
-
cytosolic fraction, myoma
0.00028
-
PAF-AH isozyme Ib alpha1 subunit, acetylhydrolase activity
0.00123
-
-
0.00236
-
PAF-AH isozyme Ib alpha2 subunit, acetylhydrolase activity
0.015
0.01572
-
-
0.02
-
partially purified enzyme
0.022
-
acetylhydrolase activity
0.038
-
-
0.0408
-
PAF-AH isozyme II, transacetylase activity
0.0445
-
plasma enzyme
0.105
-
PAF-AH isozyme II, acetylhydrolase activity
0.114
-
plasma PAF-AH, transacetylase activity
0.131
-
plasma PAF-AH, acetylhydrolase activity
0.176
-
purified enzyme, 37°C, pH 7.0
0.47
-
supernatant fraction
0.55
-
alveolar type II cells and 1000 x g fraction
0.77
-
macrophages
0.805
-
purified from erythrocytes
0.85
-
100000 x g fraction
1.32
-
60000 x g fraction
1.45
-
intracellular enzyme form Ib from brain
10.7
-
Ca2+-dependent PLA2, cell-free hemolymph of Rhodnius prolixus feeding with Trypanosoma rangeli epimastigotes
119
-
Ca2+-independent PLA2, hemocyte of Rhodnius prolixus feeding with Trypanosoma rangeli epimastigotes
12
-
Ca2+-independent PLA2, cell-free hemolymph of Rhodnius prolixus feeding with blood plus dexamethasone
14
-
Ca2+-independent PLA2, control, cell-free hemolymph of Rhodnius prolixus after regular blood feeding
140
-
Ca2+-independent PLA2, hemocyte of Rhodnius prolixus feeding with blood plus dexamethasone
17
-
total PLA2, cell-free hemolymph of Rhodnius prolixus feeding with blood plus dexamethasone
186
-
Ca2+-independent PLA2, control, hemocyte of Rhodnius prolixus after regular blood feeding
203
-
PAF-AH, cell-free hemolymph of Rhodnius prolixus feeding with Trypanosoma rangeli epimastigotes
21
-
total PLA2, control, cell-free hemolymph of Rhodnius prolixus after regular blood feeding
24
-
PAF-AH, control, cell-free hemolymph of Rhodnius prolixus after regular blood feeding
27.1
-
plasma
3.7
-
bronchoalveolar lavage
32
-
Ca2+-independent PLA2, cell-free hemolymph of Rhodnius prolixus feeding with Trypanosoma rangeli epimastigotes
34
-
PAF-AH, cell-free hemolymph of Rhodnius prolixus feeding with blood plus dexamethasone
381
-
Ca2+-dependent PLA2, hemocyte of Rhodnius prolixus feeding with blood plus dexamethasone
4.2
-
purifed enzyme using 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine as substrate
4.5
-
Ca2+-dependent PLA2, cell-free hemolymph of Rhodnius prolixus feeding with blood plus dexamethasone
427
-
Ca2+-dependent PLA2, hemocyte of Rhodnius prolixus feeding with Trypanosoma rangeli epimastigotes
43
-
total PLA2, cell-free hemolymph of Rhodnius prolixus feeding with Trypanosoma rangeli epimastigotes
529
-
total PLA2, hemocyte of Rhodnius prolixus feeding with blood plus dexamethasone
570
-
total PLA2, hemocyte of Rhodnius prolixus feeding with Trypanosoma rangeli epimastigotes
6.7
-
Ca2+-dependent PLA2, control, cell-free hemolymph of Rhodnius prolixus after regular blood feeding
7.2
-
cytosolic isoform II from liver
702
-
Ca2+-dependent PLA2, control, hemocyte of Rhodnius prolixus after regular blood feeding
9.46
-
plasma enzyme
915
-
total PLA2, control, hemocyte of Rhodnius prolixus after regular blood feeding
additional information