3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase

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For detailed information about 1-alkyl-2-acetylglycerophosphocholine esterase, go to the full flat file.

Word Map on EC 3.1.1.47

3.1.1.47

cardiovascular

coronary

phospholipid

atherosclerosis

cholesterol

low-density

artery

c-reactive

plaque

hdl

high-density

apolipoproteins

stroke

infarction

triglyceride

myocardial

phosphatidylcholine

lyso-paf

arachidonic

atherogenic

carotid

statin

lysophosphatidylcholine

atherogenesis

smoking

high-sensitivity

paraoxonase

hdl-associated

hscrp

3.1.1.7

lis1

spla2s

bromoenol

ldl-cholesterol

framingham

intima-media

lysopcs

antiatherogenic

proatherogenic

oxldl

medicine

lecithin:cholesterol

paf-receptor

paf-acether

isoprostanes

paf-induced

lipoproteina

diagnostics

autacoid

cholinephosphotransferase

normolipidemic

non-hdl

Reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine

Synonyms

(PAF)-acetylhydrolase, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 1-alkyl-2-acetyllecithin deacetylase, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, 2-acetyl-1-alkylglycerophosphocholine esterase, acetylhydrolase, alkylacetyl-GPC:acetylhydrolase, aspirin hydrolase, blood platelet-activating factor-acetyl hydrolase, Ca2+-independent phospholipase A2, calcium-independent serine lipase Lp-PLA2, deacetylase, 1-alkyl-2-acetyllecithin, group VII PAF acetylhydrolase homolog, group VII phospholipase A2, group VIII phospholipase A2, HpPAF-AH, HSD-PLA2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 1, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 3, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 4, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 5, LDL-associated phospholipase A2, LDL-PLA(2), lipoprotein associated phospholipase A2, lipoprotein-associated phospholipase A2, lipoprotein-associated PLA2, lipoprotein-associated platelet-activating factor acetylhydrolase, lipoprotein-PLA2, Lissencephaly-1 protein, Lp-PLA2, LpPLA2, More, PAF 2-acylhydrolase, PAF acetylhydrolase, PAF acetylhydrolase I, PAF acetylhydrolase II, PAF-acetylhydrolase, PAF-acetylhydrolase II, PAF-AH, PAF-AH (II), PAF-AH alpha, PAF-AH I, PAF-AH II, PAFAH, PAFAH alpha, PAFAH1B2, PAFAH2, phosphatide 2-acylhydrolase, phospholipase A2, PLA2, PLA2G7, PLA2G7 gene, plasma lipoprotein-associated phospholipase A2, plasma PAF acetylhydrolase, plasma PAF-AH, plasma platelet - activating factor - acetylhydrolase, plasma platelet activating factor acetylhydrolase, plasma platelet activating factor-acetylhydrolase, plasma platelet-activating factor acetylhydrolase, platelet activating factor acetylhydrolase, platelet activating factor-acetyl hydrolase, platelet activating factor-acetylhydrolase, platelet-activating factor acetyl-hydrolase, platelet-activating factor acetylhadrolase, platelet-activating factor acetylhydrolase, platelet-activating factor acetylhydrolase II, platelet-activating factor acetylhydrolyase, platelet-activating factor acetylohydrolase, platelet-activating factor-acetylhydrolase, platelet-activating-factor acetylhydrolase, Plg7p, pPAF-AH, Serine dependent phospholipase A2, serum platelet-activating factor acetylhydrolase, SpV-1, SpV-2, SpV-3, SpV-4, SpV-5, type I PAF acetylhydrolase, type I platelet-activating factor acetylhydrolase, Type II platelet-activating factor-acetylhydrolase, VIIA phospholipase A2

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.1 Carboxylic-ester hydrolases

3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase

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Results	in table
23	Activating Compound
5571	AA Sequence
19	Application
1	CAS Registry Number
33	Cloned(Commentary)
5	Crystallization (Commentary)
4717	Disease/ Diagnostics
3	Expression
13	General Information
4	General Stability
1	IC50 Value
108	Inhibitors
2	Ki Value [mM]
50	KM Value [mM]
61	Localization
11	Metals/Ions
55	Molecular Weight [Da]
106	Natural Substrates/ Products (Substrates)
171	Organism
2	Oxidation Stability
2	Pathway
69	PDB ID
23	pH Optimum
3	pH Range
1	pH Stability
8	Posttranslational Modification
44	Protein Variants
28	Purification (Commentary)
10	Reaction
20	Reaction Type
111	Reference
212	Source Tissue
73	Specific Activity [micromol/min/mg]
253	Substrates and Products (Substrate)
45	Subunits
259	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
10	Temperature Stability [°C]
17	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.1.1.47 - 1-alkyl-2-acetylglycerophosphocholine esterase

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100000

Bos taurus

intracellular enzyme form Ib from brain, gel filtration

80943

14000

Homo sapiens

x * 14000, secretory isozyme

650932

17800

Homo sapiens

P68402

2 * 17800, SpV-1 forms higher molecular weight complexes ranging from 65000 Da to 110000 Da in addition to the 35000 Da complex calculated from sequence

682621

22800

Homo sapiens

P68402

x * 22800, calculated from sequence

25000

26000

28000

29000

30000

31000

x * 25000 + x * 31000, the 25000 Da component represents the catalytic unit, SDS-PAGE

35000

37000

x * 66000, major part, + x * 37000, mino part, SDS-PAGE

653094

38000

Nippostrongylus brasiliensis

1 * 38000 + 1 * 25000, SDS-PAGE

80952

40000

4 entries

42700

Homo sapiens

1 * 42700, plasma enzyme, SDS-PAGE

80958

43000

2 entries

43000 - 67000

Homo sapiens

plasma isozyme, gel filtration

43400

residues 47-429

43491

x * 40000, cytosolic and membraneous PAF-TA, SDS-PAGE, x * 43491, PAF-AH isozyme II, amino acid sequence calculation

45000

45390

sequence of cDNA

45400

46000

x * 46000 + x * 63000, SDS-PAGE

80945

55000

2 entries

58000 - 63000

Cavia porcellus

plasma isozyme, gel filtration

653695

60000

2 entries

63000

2 entries

64000

Nippostrongylus brasiliensis

gel filtration

80952

66000

Rattus norvegicus

x * 66000, major part, + x * 37000, mino part, SDS-PAGE

653094

70000

Homo sapiens

native enzyme, gel filtration

715638