3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase
This is an abbreviated version!
For detailed information about 1-alkyl-2-acetylglycerophosphocholine esterase, go to the full flat file.
Word Map on EC 3.1.1.47
-
3.1.1.47
-
cardiovascular
-
coronary
-
phospholipid
-
atherosclerosis
-
cholesterol
-
low-density
-
artery
-
c-reactive
-
plaque
-
hdl
-
high-density
-
apolipoproteins
-
stroke
-
infarction
-
triglyceride
-
myocardial
-
phosphatidylcholine
-
lyso-paf
-
arachidonic
-
atherogenic
-
carotid
-
statin
-
lysophosphatidylcholine
-
atherogenesis
-
smoking
-
high-sensitivity
-
paraoxonase
-
hdl-associated
-
hscrp
-
3.1.1.7
-
lis1
-
spla2s
-
bromoenol
-
ldl-cholesterol
-
framingham
-
intima-media
-
lysopcs
-
antiatherogenic
-
proatherogenic
-
oxldl
-
medicine
-
lecithin:cholesterol
-
paf-receptor
-
paf-acether
-
isoprostanes
-
paf-induced
-
lipoproteina
-
diagnostics
-
autacoid
-
cholinephosphotransferase
-
normolipidemic
-
non-hdl
- 3.1.1.47
- cardiovascular
- coronary
- phospholipid
- atherosclerosis
- cholesterol
-
low-density
- artery
-
c-reactive
- plaque
- hdl
-
high-density
-
apolipoproteins
- stroke
- infarction
- triglyceride
- myocardial
- phosphatidylcholine
-
lyso-paf
-
arachidonic
-
atherogenic
-
carotid
- statin
- lysophosphatidylcholine
- atherogenesis
-
smoking
-
high-sensitivity
- paraoxonase
-
hdl-associated
-
hscrp
-
3.1.1.7
- lis1
-
spla2s
-
bromoenol
-
ldl-cholesterol
-
framingham
-
intima-media
-
lysopcs
-
antiatherogenic
-
proatherogenic
-
oxldl
- medicine
-
lecithin:cholesterol
-
paf-receptor
-
paf-acether
- isoprostanes
-
paf-induced
-
lipoproteina
- diagnostics
-
autacoid
-
cholinephosphotransferase
-
normolipidemic
-
non-hdl
Reaction
Synonyms
(PAF)-acetylhydrolase, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 1-alkyl-2-acetyllecithin deacetylase, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, 2-acetyl-1-alkylglycerophosphocholine esterase, acetylhydrolase, alkylacetyl-GPC:acetylhydrolase, aspirin hydrolase, blood platelet-activating factor-acetyl hydrolase, Ca2+-independent phospholipase A2, calcium-independent serine lipase Lp-PLA2, deacetylase, 1-alkyl-2-acetyllecithin, group VII PAF acetylhydrolase homolog, group VII phospholipase A2, group VIII phospholipase A2, HpPAF-AH, HSD-PLA2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 1, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 3, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 4, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 5, LDL-associated phospholipase A2, LDL-PLA(2), lipoprotein associated phospholipase A2, lipoprotein-associated phospholipase A2, lipoprotein-associated PLA2, lipoprotein-associated platelet-activating factor acetylhydrolase, lipoprotein-PLA2, Lissencephaly-1 protein, Lp-PLA2, LpPLA2, More, PAF 2-acylhydrolase, PAF acetylhydrolase, PAF acetylhydrolase I, PAF acetylhydrolase II, PAF-acetylhydrolase, PAF-acetylhydrolase II, PAF-AH, PAF-AH (II), PAF-AH alpha, PAF-AH I, PAF-AH II, PAFAH, PAFAH alpha, PAFAH1B2, PAFAH2, phosphatide 2-acylhydrolase, phospholipase A2, PLA2, PLA2G7, PLA2G7 gene, plasma lipoprotein-associated phospholipase A2, plasma PAF acetylhydrolase, plasma PAF-AH, plasma platelet - activating factor - acetylhydrolase, plasma platelet activating factor acetylhydrolase, plasma platelet activating factor-acetylhydrolase, plasma platelet-activating factor acetylhydrolase, platelet activating factor acetylhydrolase, platelet activating factor-acetyl hydrolase, platelet activating factor-acetylhydrolase, platelet-activating factor acetyl-hydrolase, platelet-activating factor acetylhadrolase, platelet-activating factor acetylhydrolase, platelet-activating factor acetylhydrolase II, platelet-activating factor acetylhydrolyase, platelet-activating factor acetylohydrolase, platelet-activating factor-acetylhydrolase, platelet-activating-factor acetylhydrolase, Plg7p, pPAF-AH, Serine dependent phospholipase A2, serum platelet-activating factor acetylhydrolase, SpV-1, SpV-2, SpV-3, SpV-4, SpV-5, type I PAF acetylhydrolase, type I platelet-activating factor acetylhydrolase, Type II platelet-activating factor-acetylhydrolase, VIIA phospholipase A2
ECTree
3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esteraseAdvanced search results
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Natural Substrates Products on EC 3.1.1.47 - 1-alkyl-2-acetylglycerophosphocholine esterase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecanoyl-sn-glycero-3-phosphocholine
-
transacetylation
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
the transacetylase activity may acetylate extracellular lyso-PAF into biologically active PAF
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, substrate and enzyme play important roles in inflammation processes
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
F2-isoprostane phospholipid + H2O
F2-isoprostane + phospholipid
-
plays key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo, involved in oxidative stress response
-
-
?
phospholipid + H2O
?
-
degradation of phospholipids produced by oxidative stress
-
-
?
phospholipids + H2O
?
-
hydrolyzes sn-2-ester bonds of fragmented or oxidized phospholipids, enzyme deficiency results in an increased risk of stroke, coronary artery disease, atherosclerotic occlusive disease, and abdominal aortic aneurysm
-
-
?
platelet-activating factor + H2O
lyso-platelet-activating factor + acetate
-
-
-
-
?
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, protection against toxic effects of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
platelet-activating factor
lyso-platelet-activating factor
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
regulation of platelet-activating factor, essential for epithelial morphogenesis
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
inactivation of platelet-activating factor, up-regulation of enzyme by pioglitazone reduces cell elongation
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, anti-inflammatory enzyme
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, enzyme could play an important role in the development or down regulation of inflammation in acute respiratory distress syndrome
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor, important role in inflammation and in atherosclerotic processes related to the metabolic syndrome
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
platelet-activating factor
lyso-platelet-activating factor
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
regulation of platelet-activating factor, anti apoptotic protein
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
enzyme from red blood cells is not involved in the degradation of platelet-activating factor accumulated in blood
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate is a potent inflammatory mediator
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
inactivation of the substrate which represents a wide variety of bioactivities, including hypotension, platelat activation, bronchoconstriction
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the enzyme abolishes the inflammatory effects of the substrate on leukocytes and the vasculature
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate mediates a wide spectrum of actions, including hypotension, changes in smooth muscle tone, vascular permeability, signalling in inflammation and allergy. The intracelluar form of the enzyme regulates the accumulation of the substrate, e.g. in macrophages and platelets
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
biological inactivation of the platelet-activation factor by hydrolysis of the acetyl group at sn-2 position which is essential for activity of PAF
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibits the initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
enzyme plays an important role in inflammatory diseases and artherosclerosis, and is involved in non-insulin dependent diabetes mellitus, the level of free, LDL- and/or HDL-associated enzyme is important, overview
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, hydrolysis of sn-2 ester bond of platelet-activating factor PAF and related inflammatory phospholipids, attenuation of their bioactivity, the beta-subunit of intracellular isozyme type II is encoded by gene LIS1, mutations of which cause Miller-Dieker lissencephaly
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, the enzyme converts the proinflammatory autocoid platelet-activating factor PAF into biologically inactive lyso-PAF, by the removal of the sn-2 acetyl group
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O
1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, biological inactivation by deacetylation
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
-
?
oxidized phospholipids + H2O
?
-
protection against toxic effects of oxidized phospholipids
-
-
?
oxidized phospholipids + H2O
?
-
degradation of oxidized phospholipids formed during the oxidative modification of low-density lipoprotein
-
-
?
platelet activating factor + H2O
acetate + deacetylated platelet activating factor
-
erythrocyte and plasma PAF acetylhydrolases
-
-
?
platelet activating factor + H2O
acetate + deacetylated platelet activating factor
-
-
-
-
?
additional information
?
-
enzyme plays a critical role in control of neuronal migration during cortex development
-
?
additional information
?
-
-
enzyme plays a critical role in control of neuronal migration during cortex development
-
?
additional information
?
-
-
one of the physiological roles of isozyme II is to diversify the biological function of PAF by producing different lipid mediators such as analogues of PAF and C2-ceramide, mutations of the gene encoding the enzyme lead to severe diseases, e.g. brain impairment, mental retardation, or lymphoma development
-
?
additional information
?
-
-
hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
-
hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids
-
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
enzyme level in vivo is linked to the LDL-level, physiological functions of isozymes, overview, the beta-subunit of isozyme Ib interacts with tubulin and with microtubule-associated proteins
-
?
additional information
?
-
-
HDL-associated plasma isozyme may be involved in the protective role of HDL in artherosclerosis, plasma enzyme is associated to LDL, preferably LDL-5 and VLDL-1 particles, the enzyme contributes to the oxidation of LDL in increasing the content of lysoPAF, inflammatory and vascular diseases alter the plasma isozyme activity, enzyme is involved in several diseases and deficiencies, overview
-
?
additional information
?
-
-
individuals with primary heterozygous or homozygous familial hypercholesterolemia show enhanced plasma enzyme activity compared to normolipidemic controls, thereby the level of plasma LDL, to which the enzyme is associated, is increased as well as the enzyme activity per LDL particle, level and activity of HDL-associated enzyme is unaltered
-
?
additional information
?
-
-
isozyme II activity is 3fold increased insubjects suffering meningitis
-
?
additional information
?
-
-
plasma isozyme is bound to LDL and HDL particles
-
?
additional information
?
-
-
the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role
-
?
additional information
?
-
-
the enzyme is associated to low-density lipoprotein LDL particles, both enzyme activities, acetylhydrolase and transacetylase, decrease during LDL oxidation
-
?
additional information
?
-
-
the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview
-
?
additional information
?
-
-
enzyme activity is suggested to be an important marker for atherogenicity
-
-
?
additional information
?
-
-
blood plasma PAF-AH plays an antiinflammatory role in the pathogenesis of human diseases such as asthma and septic shock
-
-
?
additional information
?
-
-
PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo
-
-
?
additional information
?
-
PAF-AH II exerts strong neuroprotective effects against ischemic injury
-
-
?
additional information
?
-
-
PAF-AH II exerts strong neuroprotective effects against ischemic injury
-
-
?
additional information
?
-
-
platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis
-
-
?
additional information
?
-
platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis
-
-
?
additional information
?
-
-
platelet-activating factor acetylhydrolase serves as a decapacitation factor
-
-
?
additional information
?
-
-
the type 1 PAF acetylhydrolase is one of three mammalian family members of the group 7 phospholipase A2 family, a family that is unique in that all members require a short sn-2 ester such as the acetyl ester of PAF
-
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
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PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
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PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
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the PAF-AH (I) catalytic subunits induces centrosomal amplification and microtubule disorganization by disturbing intracellular localization of LIS1 (a causative gene product for type I lissencephaly)
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PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity
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additional information
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PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity
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additional information
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physiological functions of isozymes, overview
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substrate specificity, mammalian isozyme II possesses transacetylase activity as well
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physiological functions of isozymes, overview
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recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration
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additional information
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recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration
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