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3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase

This is an abbreviated version!
For detailed information about 1-alkyl-2-acetylglycerophosphocholine esterase, go to the full flat file.

Word Map on EC 3.1.1.47

Reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine
+
H2O
=
1-alkyl-sn-glycero-3-phosphocholine
 +
acetate

Synonyms

(PAF)-acetylhydrolase, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 1-alkyl-2-acetyllecithin deacetylase, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, 2-acetyl-1-alkylglycerophosphocholine esterase, acetylhydrolase, alkylacetyl-GPC:acetylhydrolase, aspirin hydrolase, blood platelet-activating factor-acetyl hydrolase, Ca2+-independent phospholipase A2, calcium-independent serine lipase Lp-PLA2, deacetylase, 1-alkyl-2-acetyllecithin, group VII PAF acetylhydrolase homolog, group VII phospholipase A2, group VIII phospholipase A2, HpPAF-AH, HSD-PLA2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 1, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 2, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 3, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 4, intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 5, LDL-associated phospholipase A2, LDL-PLA(2), lipoprotein associated phospholipase A2, lipoprotein-associated phospholipase A2, lipoprotein-associated PLA2, lipoprotein-associated platelet-activating factor acetylhydrolase, lipoprotein-PLA2, Lissencephaly-1 protein, Lp-PLA2, LpPLA2, More, PAF 2-acylhydrolase, PAF acetylhydrolase, PAF acetylhydrolase I, PAF acetylhydrolase II, PAF-acetylhydrolase, PAF-acetylhydrolase II, PAF-AH, PAF-AH (II), PAF-AH alpha, PAF-AH I, PAF-AH II, PAFAH, PAFAH alpha, PAFAH1B2, PAFAH2, phosphatide 2-acylhydrolase, phospholipase A2, PLA2, PLA2G7, PLA2G7 gene, plasma lipoprotein-associated phospholipase A2, plasma PAF acetylhydrolase, plasma PAF-AH, plasma platelet - activating factor - acetylhydrolase, plasma platelet activating factor acetylhydrolase, plasma platelet activating factor-acetylhydrolase, plasma platelet-activating factor acetylhydrolase, platelet activating factor acetylhydrolase, platelet activating factor-acetyl hydrolase, platelet activating factor-acetylhydrolase, platelet-activating factor acetyl-hydrolase, platelet-activating factor acetylhadrolase, platelet-activating factor acetylhydrolase, platelet-activating factor acetylhydrolase II, platelet-activating factor acetylhydrolyase, platelet-activating factor acetylohydrolase, platelet-activating factor-acetylhydrolase, platelet-activating-factor acetylhydrolase, Plg7p, pPAF-AH, Serine dependent phospholipase A2, serum platelet-activating factor acetylhydrolase, SpV-1, SpV-2, SpV-3, SpV-4, SpV-5, type I PAF acetylhydrolase, type I platelet-activating factor acetylhydrolase, Type II platelet-activating factor-acetylhydrolase, VIIA phospholipase A2

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase

Inhibitors

Inhibitors on EC 3.1.1.47 - 1-alkyl-2-acetylglycerophosphocholine esterase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-Alkyl-2,3-diacetyl-sn-glycerol
-
slight
1-Hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine
-
-
1-O-alkyl-2-acetyl-sn-glycero-3-phosphodimethylethanolamine
-
-
1-O-alkyl-2-acetyl-sn-glycero-3-phosphoethanolamine
-
-
1-O-alkyl-2-acetyl-sn-glycero-3-phosphomonomethylethanolamine
-
-
1-O-alkyl-2-propionyl-sn-glycero-3-phosphocholine
-
-
1-O-hexadecanoyl-sn-glycero-3-phosphocholine
-
competitive inhibition of acetylhydrolase activity
1-O-hexadecyl-2-acetyl-rac-glycerol
-
-
1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine
-
-
1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phosphocholine
-
-
1-O-hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine
-
-
1-O-hexadecyl-2-thioacetyl-sn-glycero-3-phosphocholine
1-oleyl-2-acetyl-sn-glycerol
-
-
2-acetyl-1-acyl-glycero-sn-glycero-3-phosphocholine
-
-
2-N-methylcarbamyl platelet-activating factor
-
3-Hexadecyl-2-acetyl-sn-glycero-1-phosphocholine
-
-
4-(2-aminoethyl)benzenesulfonyl fluoride
-
i.e. pefabloc, inhibits both acetylhydrolase and transacetylase activities completely at 0.05 mM for the native enzyme, and at 1 mM for the recombinant enzyme
4-(phenylthio)-N-(4-phenyl-2-oxobutyl)azetidin-2-one
-
-
4-bromophenacyl bromide
-
-
5,5'-dithiobis(2-nitrobenzoate)
5,5'-dithiobis-2-nitrobenzoic acid
-
atorvastatin
-
reduces LDL-associated enzyme activity by reduction of LDL amount, does not reduce enzyme secretion by macrophages
benzodioxaphosphorin 2-oxides
-
BN 50739
-
antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression
Ca2+
-
18% inhibition at 10 mM
chlorpyrifos oxon
corticoids
-
regulatory function on the enzyme form from HL-60 cells
-
croton oil
-
regulatory function on the enzyme form from plasma
-
CV 3988
-
-
deoxycholate
-
-
diazoxon
diethyldicarbonate
-
-
diisopropyl fluorophosphates
-
diisopropylfluorophosphate
dithioerythritol
-
-
DTNB
-
69% inhibition at 2 mM
Estrogens
-
regulatory function on the enzyme form from plasma
-
fenofibrate
-
decreases total plasma and LDL_associated enzyme activity but does not influence HDL-associated enzyme activity
IFN-gamma
-
regulatory function on the enzyme form from monocyte-derived macrophages
-
interleukin-1alpha
-
regulatory function on the enzyme form from decidual macrophages
-
interleukin-1beta
-
regulatory function on the enzyme form from decidual macrophages
-
interleukin-8
-
regulatory function on the enzyme form from decidual and monocyte-derived macrophages
-
iodoacetamide
lipopolysaccharides
-
lyso-2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine
-
22% inhibition at 0.05 mM
lyso-platelet-activating factor
-
regulatory function on the enzyme form from hepatocytes
methoxy arachidonyl fluorophosphonate
-
type 1 PAF acetylhydrolase is irreversibly inhibited
methyl arachidonyl fluorophosphonate
n-alkyl methylphosphonofluoridates
-
N-tosyl-L-lysine chloromethyl ketone
-
-
N-tosyl-L-phenylalanyl chloromethyl ketone
-
-
p-bromophenacyl bromide
p-bromophenacylbromide
p-nitroguanidinobenzoate
-
-
pefabloc
-
-
pepstatin A
-
-
phenylmethylsulfonyl fluoride
phosphatidylcholine
-
from egg, long chain diacetyl type, slight
phosphocholine
-
25% inhibition at 0.05 mM
platelet activating factor
-
competitive
SB-677116
-
-
-
SB222657
-
-
Sulfonyl fluorides
tribufos
tumor growth factor-beta
-
regulatory function on the enzyme form from HL-60 cells
-
tumor necrosis factor-alpha
-
regulatory function on the enzyme form from decidual macrophages
-
WEB 2170
-
antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression
additional information
-