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Literature summary for 3.1.1.47 extracted from

  • Tsoukatos, D.C.; Liapikos, T.A.; Tselepis, A.D.; Chapman, M.J.; Ninio, E.
    Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein (2001), Biochem. J., 357, 457-464.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1-O-hexadecanoyl-sn-glycero-3-phosphocholine competitive inhibition of acetylhydrolase activity Homo sapiens
4-(2-aminoethyl)benzenesulfonyl fluoride i.e. pefabloc, inhibits both acetylhydrolase and transacetylase activities completely at 0.05 mM for the native enzyme, and at 1 mM for the recombinant enzyme Homo sapiens
diisopropylfluorophosphate inhibits both acetylhydrolase and transacetylase activities completely at 20 mM for the native and the recombinant enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information the recombinant enzyme shows allosteric kinetics in the transacetylation reaction Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion, plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-sn-glycero-3-phosphocholine Homo sapiens transacetylation 1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecanoyl-sn-glycero-3-phosphocholine
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine Homo sapiens the transacetylase activity may acetylate extracellular lyso-PAF into biologically active PAF 1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O Homo sapiens i.e. platelet-activation factor, biological inactivation by deacetylation 1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
?
additional information Homo sapiens the enzyme is associated to low-density lipoprotein LDL particles, both enzyme activities, acetylhydrolase and transacetylase, decrease during LDL oxidation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate the enzyme possesses both acetylhydrolase and transacetylase activities which remove PAF and its ether-linked analogues from LDL-particles upon LDL oxidation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.015
-
transacetylase activity Homo sapiens
0.022
-
acetylhydrolase activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-sn-glycero-3-phosphocholine transacetylase activity Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecanoyl-sn-glycero-3-phosphocholine
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-sn-glycero-3-phosphocholine transacetylation Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecanoyl-sn-glycero-3-phosphocholine
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine transacetylase activity Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine the transacetylase activity may acetylate extracellular lyso-PAF into biologically active PAF Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor PAF Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
?
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, biological inactivation by deacetylation Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
?
2-butanoyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine transacetylase activity, 40% of the activity with PAF Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + 2-butanoyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
?
2-propionyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine transacetylase activity, 73% of the activity with PAF Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + 2-propionyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
?
2-valeroyl-1-hexadecyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine transacetylase activity, 17% of the activity with PAF Homo sapiens 1-hexadecyl-sn-glycero-3-phosphocholine + 2-valeroyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
?
additional information cholesteryl acetate is inactive as acetyl donor in the transacetylation reaction Homo sapiens ?
-
?
additional information the enzyme is associated to low-density lipoprotein LDL particles, both enzyme activities, acetylhydrolase and transacetylase, decrease during LDL oxidation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PAF acetylhydrolase
-
Homo sapiens
PAF-AH
-
Homo sapiens
platelet-activating factor acetylhydrolase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
60 min, complete inactivation of both activities, acetylhydrolase and transacetylase Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens