Application | Comment | Organism |
---|---|---|
diagnostics | the plasma enzyme is an important risk marker for endothelial dysfunction in patients with non-insulin dependent diabetes mellitus | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | enzyme plays an important role in inflammatory diseases and artherosclerosis, and is involved in non-insulin dependent diabetes mellitus, the level of free, LDL- and/or HDL-associated enzyme is important, overview | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate | hydrolysis and inactivation of the lipid mediator platelet-activating factor PAF and/or oxidized phospholipids | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity of free, LDL-, and HDL-associated enzyme in healthy and diabetic persons | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-myristoyl-2-(4-nitrophenyl succinyl)phosphatidylcholine + H2O | artificial substrate | Homo sapiens | 1-myristoyl-phosphatidylcholine + 4-nitrophenyl succinate | 4-nitrophenyl succinate spontaneously degrades and liberates 4-nitrophenol | ? | |
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Homo sapiens | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | enzyme plays an important role in inflammatory diseases and artherosclerosis, and is involved in non-insulin dependent diabetes mellitus, the level of free, LDL- and/or HDL-associated enzyme is important, overview | Homo sapiens | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipoprotein-associated phospholipase A2 | - |
Homo sapiens |
PAF-AH | - |
Homo sapiens |
plasma platelet - activating factor - acetylhydrolase | - |
Homo sapiens |