Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme activity of the bronchoalveolar lavage is reduced in hyperoxia, but not in plasma | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretion, association to membranes, plasma | Rattus norvegicus | - |
- |
membrane | cell surface | Rattus norvegicus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | Rattus norvegicus | i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alveolar cell type II | - |
Rattus norvegicus | - |
bronchoalveolar lavage | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
macrophage | - |
Rattus norvegicus | - |
plasma | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
hyperoxemic rats show reduced activity in bronchoalveolar lavage, but not in plasma | Rattus norvegicus |
0.47 | - |
supernatant fraction | Rattus norvegicus |
0.55 | - |
alveolar type II cells and 1000 x g fraction | Rattus norvegicus |
0.77 | - |
macrophages | Rattus norvegicus |
0.85 | - |
100000 x g fraction | Rattus norvegicus |
1.32 | - |
60000 x g fraction | Rattus norvegicus |
3.7 | - |
bronchoalveolar lavage | Rattus norvegicus |
27.1 | - |
plasma | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma | Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
(PAF)-acetylhydrolase | - |
Rattus norvegicus |
PAF-AH | - |
Rattus norvegicus |
platelet-activating factor acetylhydrolase | - |
Rattus norvegicus |