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Literature summary for 3.1.1.47 extracted from
- The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats (2000), J. Biol. Chem., 275, 19891-19896.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| lipopolysaccharides | induce plasma enzyme expression in several tissues, overview, induction is 50% inhibited by administration of antagonists BN 50739 and WEB 2170 | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BN 50739 | antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression | Rattus norvegicus |  |
| WEB 2170 | antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | Rattus norvegicus | i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
healthy and endotoxemic rats, plasma type enzyme | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | plasma isozyme | Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| Kupffer cell | only after induction of plasma isozyme expression by lipopolysaccharides | Rattus norvegicus | - |
| leukocyte | circulating | Rattus norvegicus | - |
| liver | lobule, Kupffer cells | Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| macrophage | resident ones of the liver, and peritoneal | Rattus norvegicus | - |
| plasma | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| thymus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
| 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage | Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAF acetylhydrolase | - |
Rattus norvegicus |
| PAF-AH | - |
Rattus norvegicus |
| platelet-activating factor acetylhadrolase | - |
Rattus norvegicus |
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