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Literature summary for 3.1.1.47 extracted from
- Platelet-activating factor acetylhydrolase in the male reproductive tract: origin and properties (1993), Int. J. Androl., 16, 121-127.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | 10 mM, 80% inhibition of seminal plasma enzyme | Homo sapiens |  |
| phenylmethylsulfonyl fluoride | 13 mM, 50% inhibition of seminal plasma enzyme | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.052 | - |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | enzyme from vas deferens fluid | Homo sapiens | |
| 0.054 | - |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | enzyme from seminal vesicle fluid | Homo sapiens | |
| 0.081 | - |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | enzyme from prostatic fluid | Homo sapiens | |
| 0.175 | - |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | enzyme from serum | Homo sapiens | |
| 0.392 | - |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | enzyme from seminal plasma | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate fluid | - |
Homo sapiens | - |
| seminal plasma | - |
Homo sapiens | - |
| seminal vesicle | fluid | Homo sapiens | - |
| serum | - |
Homo sapiens | - |
| vas deferens | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | i.e. PAF | Homo sapiens | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
30 min, complete inactivation | Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 3 | - |
complete inactivation | Homo sapiens |
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