Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | 1.3fold increase in activity, isozyme II from cerebrospinal fluid | Homo sapiens | |
additional information | 3fold increase in activity in subjects with meningitis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetamide | 17% inhibition at 5 mM | Homo sapiens | |
additional information | no inhibition of the isozyme II from cerebrospinal fluid by NaF, Mg2+, Ca2+, and EDTA | Homo sapiens | |
p-bromophenacylbromide | 60% inhibition at 5 mM, isozyme II from cerebrospinal fluid | Homo sapiens | |
PMSF | 80% inhibition at 5 mM, complete inhibition at 10 mM, isozyme II from cerebrospinal fluid | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme from cerebrospinal fluid is Ca2+-independent | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
1 * 45000, isozyme II, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | i.e. platelet-activation factor | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | Homo sapiens | isozyme II activity is 3fold increased insubjects suffering meningitis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
children with meningitis | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebrospinal fluid | isozyme II, of children with meningitis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acyl-2-linoleoyl-glycero-phosphocholine + H2O | - |
Homo sapiens | 2-linoleoyl-glycero-phosphocholine + acylic acid | - |
? | |
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Homo sapiens | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | isozyme II from cerebrospinal fluid does not degrade phospholipids with a long chain fatty acyl group at sn-2 position | Homo sapiens | ? | - |
? | |
additional information | isozyme II activity is 3fold increased insubjects suffering meningitis | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 45000, isozyme II, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PAF-AH | - |
Homo sapiens |
platelet-activating factor acetylhydrolase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
30 min, stable up to, gradually decrease at temperatures above 40°C | Homo sapiens |
70 | - |
30 min, inactivation | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4 | 11 | broad range, inactivation below pH 4.0 | Homo sapiens |