EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
3T3-L1 cell |
- |
686411, 697625, 700121, 700180, 712594, 740806 |
1.1.1.205 | IMP dehydrogenase |
3T3-L1 cell |
- |
702061 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
3T3-L1 cell |
- |
739138 |
1.1.1.44 | phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) |
3T3-L1 cell |
- |
685541 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
3T3-L1 cell |
- |
699948, 760740 |
1.11.1.20 | prostamide/prostaglandin F2alpha synthase |
3T3-L1 cell |
- |
740711 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
3T3-L1 cell |
- |
745769 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
3T3-L1 cell |
- |
746217 |
1.14.18.6 | 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase |
3T3-L1 cell |
- |
734433 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
3T3-L1 cell |
- |
687766, 746212 |
1.3.1.48 | 13,14-dehydro-15-oxoprostaglandin 13-reductase |
3T3-L1 cell |
- |
687562 |
1.3.3.6 | acyl-CoA oxidase |
3T3-L1 cell |
- |
671758 |
1.3.99.23 | all-trans-retinol 13,14-reductase |
3T3-L1 cell |
- |
-, 700994, 763507 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
3T3-L1 cell |
- |
685345 |
2.1.1.17 | phosphatidylethanolamine N-methyltransferase |
3T3-L1 cell |
- |
719858 |
2.1.1.348 | mRNA m6A methyltransferase |
3T3-L1 cell |
- |
757661 |
2.3.1.108 | alpha-tubulin N-acetyltransferase |
3T3-L1 cell |
- |
735631 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
3T3-L1 cell |
- |
756106, 757868 |
2.3.1.20 | diacylglycerol O-acyltransferase |
3T3-L1 cell |
- |
758179 |
2.3.1.48 | histone acetyltransferase |
3T3-L1 cell |
- |
688978 |
2.3.1.85 | fatty-acid synthase system |
3T3-L1 cell |
- |
660895 |
2.3.3.8 | ATP citrate synthase |
3T3-L1 cell |
- |
736797 |
2.4.1.255 | protein O-GlcNAc transferase |
3T3-L1 cell |
- |
693100 |
2.4.1.80 | ceramide glucosyltransferase |
3T3-L1 cell |
- |
679436 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
3T3-L1 cell |
- |
735872, 759503 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
3T3-L1 cell |
- |
759485 |
2.7.1.137 | phosphatidylinositol 3-kinase |
3T3-L1 cell |
- |
709772 |
2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase |
3T3-L1 cell |
- |
723139 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
3T3-L1 cell |
- |
676001 |
2.7.10.1 | receptor protein-tyrosine kinase |
3T3-L1 cell |
- |
721490 |
2.7.11.1 | non-specific serine/threonine protein kinase |
3T3-L1 cell |
- |
761503 |
2.7.11.11 | cAMP-dependent protein kinase |
3T3-L1 cell |
- |
694155 |
2.7.11.24 | mitogen-activated protein kinase |
3T3-L1 cell |
- |
740424 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
3T3-L1 cell |
- |
665636, 702510, 703277 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
3T3-L1 cell |
- |
738392 |
2.7.4.3 | adenylate kinase |
3T3-L1 cell |
- |
722732 |
2.7.7.41 | phosphatidate cytidylyltransferase |
3T3-L1 cell |
- |
738826 |
2.8.2.4 | estrone sulfotransferase |
3T3-L1 cell |
- |
-, 725979, 760988 |
3.1.1.3 | triacylglycerol lipase |
3T3-L1 cell |
- |
707547, 708289 |
3.1.1.5 | lysophospholipase |
3T3-L1 cell |
- |
693213 |
3.1.1.79 | hormone-sensitive lipase |
3T3-L1 cell |
- |
714794 |
3.1.3.4 | phosphatidate phosphatase |
3T3-L1 cell |
- |
680814, 708998, 709417, 709945, 714316 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
3T3-L1 cell |
- |
751121 |
3.1.3.48 | protein-tyrosine-phosphatase |
3T3-L1 cell |
- |
729290 |
3.1.3.86 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase |
3T3-L1 cell |
- |
750315 |
3.1.4.11 | phosphoinositide phospholipase C |
3T3-L1 cell |
- |
716113 |
3.4.11.3 | cystinyl aminopeptidase |
3T3-L1 cell |
- |
-, 669191, 683133, 709666, 754109, 755404 |
3.4.11.4 | tripeptide aminopeptidase |
3T3-L1 cell |
- |
679509 |
3.4.21.46 | complement factor D |
3T3-L1 cell |
- |
755129 |
3.4.21.B26 | proprotein convertase 5 |
3T3-L1 cell |
- |
675967 |
3.4.22.38 | cathepsin K |
3T3-L1 cell |
- |
695943 |
3.4.22.52 | calpain-1 |
3T3-L1 cell |
- |
707364 |
3.4.24.B3 | matrix metalloproteinase-11 |
3T3-L1 cell |
- |
694496 |
3.6.5.2 | small monomeric GTPase |
3T3-L1 cell |
- |
699992, 701352 |
4.1.1.29 | sulfinoalanine decarboxylase |
3T3-L1 cell |
- |
693792 |
4.1.1.65 | phosphatidylserine decarboxylase |
3T3-L1 cell |
- |
715603 |
4.1.2.27 | sphinganine-1-phosphate aldolase |
3T3-L1 cell |
- |
681269 |
5.2.1.8 | peptidylprolyl isomerase |
3T3-L1 cell |
- |
715609 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
3T3-L1 cell |
- |
747492 |
6.2.1.16 | acetoacetate-CoA ligase |
3T3-L1 cell |
- |
691065, 727116 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
3T3-L1 cell |
- |
662593 |
6.3.4.2 | CTP synthase (glutamine hydrolysing) |
3T3-L1 cell |
- |
727427 |
6.4.1.1 | pyruvate carboxylase |
3T3-L1 cell |
- |
690828, 705517 |
2.3.1.20 | diacylglycerol O-acyltransferase |
3T3-L1 cell |
3T3-L1 fibroblasts differentiated into adipocytes |
486513 |
3.1.3.1 | alkaline phosphatase |
3T3-L1 cell |
activity increases during adipogenesis |
677519 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
3T3-L1 cell |
adipocyte |
640921 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
3T3-L1 cell |
adipocyte cell line |
664718 |
3.5.4.16 | GTP cyclohydrolase I |
3T3-L1 cell |
adipocyte cell line |
667769 |
3.1.1.3 | triacylglycerol lipase |
3T3-L1 cell |
adipocytes, enzyme expression during differentiation of adipocytes, maximal at day 8, overview |
664719 |
1.1.1.188 | prostaglandin-F synthase |
3T3-L1 cell |
AKR1B3 mRNA 9 is expressed in preadipocytes, and its level increases about 4fold at day 1 after initiation of adipocyte differentiation, and then quickly decreases the following day to a level lower than that in the preadipocytes |
712494 |
3.4.22.38 | cathepsin K |
3T3-L1 cell |
ATCC CL-173 |
697619 |
4.1.2.27 | sphinganine-1-phosphate aldolase |
3T3-L1 cell |
CL 173 (ATCC) |
5119 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
3T3-L1 cell |
conjugated linoleic acid decreases SCD1 gene expression |
675626 |
2.3.1.21 | carnitine O-palmitoyltransferase |
3T3-L1 cell |
CPT I and CPT II |
486577 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
3T3-L1 cell |
differentiation of cells causes a strong increase in 11beta-hydroxysteroid dehydrogenase protein levels, occuring late in the differentiation protocol. Reduction of 11beta-hydroxysteroid dehydrogenase activity in 3T3-L1 fibroblasts, achieved by pharmacological inhibition or adenovirally mediated delivery of short hairpin RNA constructs, specifically blocks the ability of inactive glucocorticoids to drive 3T3-L1 differentiation. Even modest increases in exogenous 11beta-hydroxysteroid dehydrogenase expression in 3T3-L1 fibroblasts, to levels comparable with endogenous 1 11beta-hydroxysteroid dehydrogenase in differentiated 3T3-L1 adipocytes, are sufficient to block adipogenesis |
692987 |
2.1.1.1 | nicotinamide N-methyltransferase |
3T3-L1 cell |
elevated enzyme activity during cell differentiation in adipose tissue |
701990 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
3T3-L1 cell |
Gpat3 mRNA increases 60fold during differentiation of 3T3-L1 preadipocytes to mature adipocytes, suggesting a critical role in adipocytes |
701623 |
2.7.10.1 | receptor protein-tyrosine kinase |
3T3-L1 cell |
HER2 is absent in undifferentiated cultures of adipocytes, not subjected to hormonal treatment but processed at the same time as the differentiating cultures from day 0 to day 14. Expression of HER2 significantly augments during the differentiation of preadipocytes. HER2 acculmulation reaches a maximum at day 9 |
693316 |
2.7.11.1 | non-specific serine/threonine protein kinase |
3T3-L1 cell |
isozyme PKNalpha |
662053 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
3T3-L1 cell |
isozyme SCD1 is dramatically induced during 3T3L1 differentiation |
746542 |
3.1.3.4 | phosphatidate phosphatase |
3T3-L1 cell |
lipin-1 and lipin-2 |
707555 |
6.2.1.1 | acetate-CoA ligase |
3T3-L1 cell |
marked induction of AceCS1 mRNA and protein during differentiation of 3T3-L1 cells, neither AceCS2 mRNA nor protein is detected in undifferentiated or differentiated 3T3-L1 cells |
652101 |
1.17.1.4 | xanthine dehydrogenase |
3T3-L1 cell |
mRNA expression increases 8-fold during the first 12 hr postinduction and subsequently declines to preinduction levels by day 3. Xanthine dehydrogenase activity is maximally induced at 24 hr postinduction, while xanthine oxidase activity remains relatively unchanged |
672979 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
3T3-L1 cell |
pre- and post-adipocytes |
688948 |
3.1.1.34 | lipoprotein lipase |
3T3-L1 cell |
preadipocyte cell line |
-, 709009 |
1.2.3.1 | aldehyde oxidase |
3T3-L1 cell |
preadipocytes have a very low expression of AOX1, in 2 days differentiated cells AOX1 is induced and is not further upregulated in 3, 7 and 9 days differentiated cells. AOX1 mRNA is nearly four-fold higher in 2 days differentiated cells when compared to preadipocytes and doubles from days 2 to 6 |
697933 |
3.1.1.34 | lipoprotein lipase |
3T3-L1 cell |
scopoletin significantly increases lipoprotein lipase activity in 3T3-L1 adipocytes |
680239 |
2.4.1.11 | glycogen(starch) synthase |
3T3-L1 cell |
synthetic peroxisome proliferator-activated receptor beta/delta, and gamma agonists markedly up-regulate Gys-2 mRNA and protein expression in mouse 3T3-L1 adipocytes |
686019 |