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Literature summary for 1.1.1.44 extracted from

  • Shin, E.S.; Park, J.; Shin, J.M.; Cho, D.; Cho, S.Y.; Shin, D.W.; Ham, M.; Kim, J.B.; Lee, T.R.
    Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme (2008), Bioorg. Med. Chem., 16, 3580-3586.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(-)-catechin gallate NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase Mus musculus
(-)-epicatechin gallate
-
Mus musculus
(-)-epigallocatechin NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase Mus musculus
(-)-epigallocatechin gallate NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase Mus musculus
(-)-gallocatechin gallate NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase Mus musculus
additional information not inhibited by ungallated catechins like (-)-epigallocatechin, (-)-gallocatechin, (-)-epicatechin, (-)-catechin, and dehydroepiandrosterone Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-
adipocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
Mus musculus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
Mus musculus
6PGD
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00072
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C Mus musculus (-)-epigallocatechin gallate
0.00121
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C Mus musculus (-)-epicatechin gallate
0.00128
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C Mus musculus (-)-catechin gallate
0.00145
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C Mus musculus (-)-gallocatechin gallate