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Literature summary for 1.1.1.205 extracted from

  • Su, H.; Gunter, J.H.; de Vries, M.; Connor, T.; Wanyonyi, S.; Newell, F.S.; Segal, D.; Molero, J.C.; Reizes, O.; Prins, J.B.; Hutley, L.J.; Walder, K.; Whitehead, J.P.
    Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity (2009), Biochem. Biophys. Res. Commun., 386, 351-355.
    View publication on PubMed
Search for more literature for 1.1.1.205

Application

Application Comment Organism
medicine inhibition of IMPDH may represent a novel strategy to reduce adipose tissue mass Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
mycophenolate mofetil prodrug of mycophenolic acid, treatment of diet-induced obese mice with mycophenolate mofetil for 28 days does not affect food intake or lean body mass but reduces body fat content (by 36%), adipocyte size and number and the appearance of hepatic steatosis Mus musculus
Mycophenolic acid in 3T3-L1 preadipocytes inhibition of IMPDH with mycophenolic acid reduces intracellular GTP levels by 60% (p <0.05) and blocks adipogenesis. Co-treatment with guanosine restores GTP levels and adipogenesis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
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adipocyte
-
 Mus musculus
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preadipocyte
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 Mus musculus
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Synonyms

Synonyms Comment Organism
IMPDH
-
 Mus musculus
inosine monophosphate dehydrogenase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus IMPDH protein expression is transiently increased during differentiation of 3T3-L1 preadipocytes. Total IMPDH protein levels and activity are highest around day 3 up

General Information

General Information Comment Organism
physiological function IMPDH activity is required for differentiation of preadipocytes into mature, lipid-laden adipocytes and maintenance of adipose tissue mass Mus musculus