Application | Comment | Organism |
---|---|---|
medicine | inhibition of IMPDH may represent a novel strategy to reduce adipose tissue mass | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
mycophenolate mofetil | prodrug of mycophenolic acid, treatment of diet-induced obese mice with mycophenolate mofetil for 28 days does not affect food intake or lean body mass but reduces body fat content (by 36%), adipocyte size and number and the appearance of hepatic steatosis | Mus musculus | |
Mycophenolic acid | in 3T3-L1 preadipocytes inhibition of IMPDH with mycophenolic acid reduces intracellular GTP levels by 60% (p <0.05) and blocks adipogenesis. Co-treatment with guanosine restores GTP levels and adipogenesis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipocyte | - |
Mus musculus | - |
preadipocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
IMPDH | - |
Mus musculus |
inosine monophosphate dehydrogenase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | IMPDH protein expression is transiently increased during differentiation of 3T3-L1 preadipocytes. Total IMPDH protein levels and activity are highest around day 3 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | IMPDH activity is required for differentiation of preadipocytes into mature, lipid-laden adipocytes and maintenance of adipose tissue mass | Mus musculus |