Literature summary for 2.7.7.41 extracted from

Qi, Y.; Kapterian, T.S.; Du, X.; Ma, Q.; Fei, W.; Zhang, Y.; Huang, X.; Dawes, I.W.; Yang, H.
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development (2016), J. Lipid Res., 57, 767-780.

Search for more literature for 2.7.7.41

Protein Variants

Protein Variants	Comment	Organism
additional information	transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS1 by 48%. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells	Mus musculus
additional information	transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS2 by 90%. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells	Mus musculus
additional information	transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS1 by 81%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells	Homo sapiens
additional information	transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS2 by 90%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum membrane	-	Mus musculus	5789	-
endoplasmic reticulum membrane	-	Homo sapiens	5789	-
membrane	-	Mus musculus	16020	-
membrane	-	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CTP + phosphatidate	Mus musculus	-	diphosphate + CDP-diacylglycerol	-	?
CTP + phosphatidate	Homo sapiens	-	diphosphate + CDP-diacylglycerol	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O95674	-	-
Homo sapiens	Q92903	-	-
Mus musculus	P98191	-	-
Mus musculus	Q99L43	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	-	Mus musculus	-
HeLa cell	-	Homo sapiens	-
preadipocyte	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CTP + phosphatidate	-	Mus musculus	diphosphate + CDP-diacylglycerol	-	?
CTP + phosphatidate	-	Homo sapiens	diphosphate + CDP-diacylglycerol	-	?

Synonyms

Synonyms	Comment	Organism
CDP-DAG synthase	-	Mus musculus
CDP-DAG synthase	-	Homo sapiens
CDP-diacylglycerol synthase	-	Mus musculus
CDP-diacylglycerol synthase	-	Homo sapiens
CDS1	-	Mus musculus
CDS1	-	Homo sapiens
CDS2	-	Mus musculus
CDS2	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocked the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells	Mus musculus
malfunction	knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 in 3T3-L1 preadipocytes has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells	Mus musculus
malfunction	knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells	Homo sapiens
malfunction	knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells	Homo sapiens
physiological function	knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocks the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidic acid species are significantly increased upon knocking down CDS1. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2	Mus musculus
physiological function	knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidic acid species are increased upon depleting CDS2. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2	Mus musculus
physiological function	CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage	Mus musculus
physiological function	CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage	Homo sapiens

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Release 2023.1 (January 2023)