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Literature summary for 2.7.10.1 extracted from

  • Fukushima, T.; Arai, T.; Ariga-Nedachi, M.; Okajima, H.; Ooi, Y.; Iijima, Y.; Sone, M.; Cho, Y.; Ando, Y.; Kasahara, K.; Ozoe, A.; Yoshihara, H.; Chida, K.; Okada, S.; Kopchick, J.; Asano, T.; Hakuno, F.; Takahashi, S.
    Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases (2011), Biochem. Biophys. Res. Commun., 404, 767-773.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dibutyryl cAMP tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases Rattus norvegicus
tumor necrosis factor-alpha tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha.Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-
FRTL-5 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + insulin receptor substrate 1-L-tyrosine
-
Mus musculus ADP + insulin receptor substrate 1-L-tyrosine phosphate tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases ?
ATP + insulin receptor substrate 2-L-tyrosine
-
Rattus norvegicus ADP + insulin receptor substrate 2-L-tyrosine phosphate tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases ?