Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dibutyryl cAMP | tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases | Rattus norvegicus | |
tumor necrosis factor-alpha | tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha.Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
FRTL-5 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + insulin receptor substrate 1-L-tyrosine | - |
Mus musculus | ADP + insulin receptor substrate 1-L-tyrosine phosphate | tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases | ? | |
ATP + insulin receptor substrate 2-L-tyrosine | - |
Rattus norvegicus | ADP + insulin receptor substrate 2-L-tyrosine phosphate | tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases | ? |