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Literature summary for 1.1.1.40 extracted from
- Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage (2016), Nat. Chem. Biol., 12, 345-352.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NADP+ | Mus musculus | - |
pyruvate + CO2 + NADPH | - |
? |  |
| (S)-malate + NADP+ | Mus musculus | - |
pyruvate + CO2 + NADPH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Mus musculus | P06801 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3T3-L1 cell | - |
Mus musculus | - |
| adipose tissue | - |
Mus musculus | - |
| preadipocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NADP+ | - |
Mus musculus | pyruvate + CO2 + NADPH | - |
? | |
| (S)-malate + NADP+ | - |
Mus musculus | pyruvate + CO2 + NADPH | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| malic enzyme | - |
Mus musculus |
| ME1 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Mus musculus | |
| NADPH | - |
Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | during adipocyte differentiation, there is coordinate upregulation of ATP citrate lyase and cytosolic malic enzyme (ME1), which together with cytosolic malate dehydrogenase and at the expense of 1 ATP molecule, can convert citrate and NADH into acetyl-CoA, NADPH and pyruvate | Mus musculus |
| additional information | tracing carbon flux through malic enzyme, overview | Mus musculus |
| physiological function | significance of malic enzyme in fat synthesis. Malic enzyme is the main NADPH source in normoxic 3T3-L1 adipocytes, with total NADPH production more than double that from the oxidative pentose phosphate pathway | Mus musculus |
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Release 2023.1 (January 2023)
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