Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | SCD2 mRNA expression is elevated 44fold in adipose tissue upon feeding mice a high fat diet, whereas SCD1 shows little response | Mus musculus |
Cloned (Comment) | Organism |
---|---|
SCD1 and SCD2 expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | silencing of SCD1 does not downregulate 3T3-L1 cell differentiation or gene expression, inhibition of adipogenesis caused by SCD2 depletion is associated with a decrease in peroxisome proliferator-activated receptor alpha mRNA and protein, whereas in mature adipocytes loss of SCD2 diminishes PPARalpha protein levels, with little change in mRNA levels and protein translation levels | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | Mus musculus | stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipocyte | - |
Mus musculus | - |
adipose tissue | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Mus musculus | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview | Mus musculus | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCD1 | - |
Mus musculus |
SCD2 | - |
Mus musculus |
stearoyl-CoA desaturase 1 | - |
Mus musculus |
stearoyl-CoA desaturase 2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ferrocytochrome b5 | - |
Mus musculus |