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Literature summary for 3.4.22.38 extracted from

  • Yang, M.; Sun, J.; Zhang, T.; Liu, J.; Zhang, J.; Shi, M.A.; Darakhshan, F.; Guerre-Millo, M.; Clement, K.; Gelb, B.D.; Dolgnov, G.; Shi, G.P.
    Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice (2008), Arterioscler. Thromb. Vasc. Biol., 28, 2202-2208.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.38

Protein Variants

Protein Variants Comment Organism
additional information enzyme deficiency leads to blocked adipogenesis in 3T3-L1 preadipocytes, while CatK overexpression leads to enhanced adipogenesis, phenotypes, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CatK-selective inhibitor II i.e. Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z Homo sapiens
CatK-selective inhibitor II commercial preparation Mus musculus
E-64d
-
 Mus musculus
E64d
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
 x * 28000, mature CatK, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism, reducing serum glucose and insulin levels, in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview ?
-
 ?
additional information Homo sapiens deficiency and inhibition of cathepsin K reduce preadipocyte adipogenesis, body weight gain, and increase glucose metabolism in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 female C57BL/6/129S mice, wild-type and ob/ob mice
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
-
adipose tissue
-
 Mus musculus
-
commercial preparation recombinant Homo sapiens
-
macrophage peritoneal Mus musculus
-
additional information no expression in skeletal muscle Mus musculus
-
additional information negligible expression in skeletal muscle Homo sapiens
-
preadipocyte
-
 Mus musculus
-
preadipocyte subcutaneous, the enzyme content is increased by 12fold during adipogenesis Homo sapiens
-
spleen
-
 Mus musculus
-
white adipose tissue
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human plasma fibronectin + H2O recombinant enzyme Homo sapiens ?
-
 ?
additional information deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism, reducing serum glucose and insulin levels, in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview Mus musculus ?
-
 ?
additional information deficiency and inhibition of cathepsin K reduce preadipocyte adipogenesis, body weight gain, and increase glucose metabolism in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 28000, mature CatK, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
catK
-
 Mus musculus
catK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 assay at Homo sapiens