Literature summary for 1.1.1.188 extracted from

Fujimori, K.; Ueno, T.; Nagata, N.; Kashiwagi, K.; Aritake, K.; Amano, F.; Urade, Y.
Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase (2010), J. Biol. Chem., 285, 8880-8886.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	AKR1B3 mRNA 9 is expressed in preadipocytes, and its level increases about 4fold at day 1 after initiation of adipocyte differentiation, and then quickly decreases the following day to a level lower than that in the preadipocytes	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	AKR1B3 mRNA is expressed in preadipocytes, and its level increases about 4fold at day 1 after initiation of adipocyte differentiation, and then quickly decreases the following day to a level lower than that in the preadipocytes	up

General Information

General Information	Comment	Organism
physiological function	knock-down by small interfering RNA for Akr1b3 suppresses PGF2 production and enhances the expression of adipogenic genes such as peroxisome proliferator-activated receptor gamma, fatty acid-binding protein 4, and stearoyl-CoA desaturase	Mus musculus

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Release 2023.1 (January 2023)