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arachidonic acid + ATP + CoA
arachidonoyl-CoA + AMP + diphosphate
-
-
-
-
?
ATP + (11Z)-eicosenoate + CoA
AMP + diphosphate + (11Z)-eicosenoyl-CoA
-
-
?
ATP + (15Z)-tetracosenoate + CoA
AMP + diphosphate + (15Z)-tetracosenoyl-CoA
-
-
?
ATP + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA
AMP + diphosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA
-
-
?
ATP + (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
AMP + diphosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA
-
-
?
ATP + (6Z)-octadecenoate + CoA
AMP + diphosphate + (6Z)-octadecenoyl-CoA
-
-
?
ATP + (6Z,12Z, 15Z)-octadecatrienoate + CoA
AMP + diphosphate + (6Z,12Z,15Z)-octadecatrienoyl-CoA
-
-
?
ATP + (6Z,9Z,12Z)-octadecatrienoate + CoA
AMP + diphosphate + (6Z,9Z,12Z)-octadecatrienoyl-CoA
-
-
?
ATP + (9E)-octadecenoate + CoA
AMP + diphosphate + (9E)-octadecenoyl-CoA
-
-
?
ATP + (9Z)-hexadecenoate + CoA
AMP + diphosphate + (9Z)-hexadecenoyl-CoA
-
-
?
ATP + (9Z)-octadecenoate + CoA
AMP + diphosphate + (9Z)-octadecenoyl-CoA
-
-
?
ATP + (9Z)-tetradecenoate + CoA
AMP + diphosphate + (9Z)-tetradecenoyl-CoA
-
-
?
ATP + (9Z,12Z)-octadecadienoate + CoA
AMP + diphosphate + (9Z,12Z)-octadecadienoyl-CoA
-
-
?
ATP + (R)-ibuprofen + CoA
AMP + diphosphate + (R)-ibuprofenoyl-CoA
ATP + 1,12-dodecanedioic acid + CoA
AMP + diphosphate + ?
-
-
-
?
ATP + 12-oxo-phytodienoic acid + CoA
AMP + diphosphate + 12-oxo-phytodienoyl-CoA
-
-
-
-
?
ATP + 16-hydroxypalmitic acid + CoA
AMP + diphosphate + 16-hydroxypalmitoyl-CoA
-
isoenzyme LACS2
-
-
?
ATP + 20:3(n-6) fatty acid + CoA
?
-
-
-
-
?
ATP + 3-oxo-2(2'-[Z]-pentenyl)cyclopentane-1-hexanoic acid + CoA
AMP + diphosphate + 3-oxo-2(2'-[Z]-pentenyl)cyclopentane-1-hexanoyl-CoA
-
-
-
-
?
ATP + 3-oxo-2(2'-[Z]-pentenyl)cyclopentane-1-octanoic acid + CoA
AMP + diphosphate + 3-oxo-2(2'-[Z]-pentenyl)cyclopentane-1-octanoyl-CoA
-
preferred substrate
-
-
?
ATP + a long-chain carboxylate + CoA
AMP + diphosphate + an acyl-CoA
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain fatty acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + an acyl-CoA
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
ATP + acylate + CoA
AMP + diphosphate + acyl-CoA
-
-
-
-
?
ATP + alpha-linoleate + CoA
AMP + diphosphate + alpha-linoleoyl-CoA
-
best substrate
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
ATP + behenoate + CoA
AMP + diphosphate + behenoyl-CoA
-
isoform Facl1 exhibits about 20% activity and isoform Facl2 exhibits about 65% activity
-
-
?
ATP + Bodipy 500/510 C4-C9 + CoA
?
-
-
-
-
?
ATP + Bodipy-C16 + CoA
?
-
-
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
ATP + C1-Bodipy-C12 + CoA
?
-
-
-
-
?
ATP + caproate + CoA
AMP + diphosphate + caproyl-CoA
-
most preferred substrate for isoform Facl1 (100% activity)
-
-
?
ATP + capryloate + CoA
AMP + diphosphate + capryloyl-CoA
-
isoform Facl1 exhibits about 50% activity and isoform Facl2 exhibits about 45% activity
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
ATP + decenoate + CoA
AMP + diphosphate + decenoyl-CoA
-
-
-
?
ATP + dihomo-gamma-linolenate + CoA
AMP + diphosphate + dihomo-gamma-linolenoyl-CoA
-
-
-
?
ATP + dinor-12-oxo-phytodienoic acid + CoA
AMP + diphosphate + dinor-12-oxo-phytodienoyl-CoA
-
-
-
-
?
ATP + docosahexaenoate + CoA
AMP + diphosphate + docosahexaenoyl-CoA
ATP + docosenoate + CoA
AMP + diphosphate + docosenoyl-CoA
-
-
-
?
ATP + dodecanoate + CoA
AMP + diphosphate + dodecanoyl-CoA
ATP + eicosadienoate + CoA
AMP + diphosphate + eicosadienoyl-CoA
-
-
-
?
ATP + eicosanoate + CoA
AMP + diphosphate + eicosanoyl-CoA
preferred substrate of isoform ACSL4
-
-
?
ATP + eicosapentaenoate + CoA
AMP + diphosphate + eicosapentaenoyl-CoA
ATP + elaidate + CoA
AMP + diphosphate + elaiodyl-CoA
-
-
-
-
?
ATP + erucate + CoA
AMP + diphosphate + erucoyl-CoA
-
-
-
-
?
ATP + fatty acid + 4'-phosphopantetheine
AMP + diphosphate + acyl-4'-phosphopantetheine
ATP + fatty acid + dephospho-CoA
AMP + diphosphate + acyl-dephospho-CoA
ATP + fatty acid + N6-etheno-CoA
AMP + diphosphate + acyl-N6-etheno-CoA
-
-
-
-
?
ATP + fatty acid + pantetheine
AMP + diphosphate + acyl-pantetheine
ATP + heptadecanoate + CoA
AMP + diphosphate + heptadecanoyl-CoA
ATP + heptanoate + CoA
AMP + diphosphate + heptanoyl-CoA
-
-
-
-
?
ATP + hexacosanoate + CoA
AMP + diphosphate + hexacosanoyl-CoA
-
isoform Facl1 exhibits about 8% activity and isoform Facl2 exhibits about 23% activity
-
-
?
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
ATP + hexadecatrienoate + CoA
AMP + diphosphate + hexadecatrienoyl-CoA
-
-
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
ATP + jasmonic acid + CoA
AMP + diphosphate + jasmonyl-CoA
-
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
ATP + laurate + CoA
AMP + diphosphate + lauryl-CoA
-
isoform Facl1 exhibits about 90% activity and isoform Facl2 exhibits about 55% activity
-
-
?
ATP + lignocerate + CoA
AMP + diphosphate + lignoceroyl-CoA
ATP + lignocerate + CoA
AMP + diphosphate + lignoceryl-CoA
-
isoform Facl1 exhibits about 20% activity and isoform Facl2 exhibits about 30% activity
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
ATP + linoleic acid + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
?
ATP + linolenate + CoA
AMP + diphosphate + linolenoyl-CoA
ATP + long-chain carboxylic acid + CoA
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
ATP + melissoate + CoA
AMP + diphosphate + melissoyl-CoA
-
isoform Facl1 exhibits about 3% activity and isoform Facl2 exhibits about 1% activity
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
ATP + myristic acid + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
-
?
ATP + n-tetracosanoic acid + CoA
AMP + diphosphate + n-tetracosanoyl-CoA
-
-
-
-
?
ATP + nonanoate + CoA
AMP + diphosphate + nonanoyl-CoA
-
-
-
-
?
ATP + o-succinyl-1-benzoate + CoA
AMP + diphosphate + o-succinyl-1-benzoyl-CoA
ATP + octacosanoate + CoA
AMP + diphosphate + octacosanoyl-CoA
-
isoform Facl1 exhibits about 5% activity and isoform Facl2 exhibits about 3% activity
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
ATP + octanoate + CoA
AMP + diphosphate + octanoyl-CoA
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
ATP + oleic acid + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
ATP + palmitoleate + CoA
AMP + diphosphate + palmitoleoyl-CoA
ATP + pentadecanoate + CoA
AMP + diphosphate + pentadecanoyl-CoA
ATP + pristanic acid + CoA
AMP + diphosphate + pristanoyl-CoA
-
-
-
?
ATP + stearate + CoA
AMP + diphosphate + stearoyl-CoA
ATP + stearate + CoA
AMP + diphosphate + stearyl-CoA
-
isoform Facl1 exhibits about 45% activity and isoform Facl2 exhibits about 75% activity
-
-
?
ATP + tetradecanoate + CoA
AMP + diphosphate + tetradecanoyl-CoA
ATP + tridecanoate + CoA
AMP + diphosphate + tridecanoyl-CoA
ATP + undecanoate + CoA
AMP + diphosphate + undecanoyl-CoA
dATP + fatty acid + CoA
dAMP + diphosphate + acyl-CoA
decanoic acid + ATP + CoA
decanoyl-CoA + AMP + diphosphate
lauric acid + ATP + CoA
lauroyl-CoA + AMP + diphosphate
linoleic acid + ATP + CoA
linoleoyl-CoA + AMP + diphosphate
linolenic acid + ATP + CoA
linolenoyl-CoA + AMP + diphosphate
-
-
-
-
?
luciferin + O2 + ATP
oxidized luciferin + CO2 + H2O + AMP + diphosphate + hv
myristic acid + ATP + CoA
myristoyl-CoA + AMP + diphosphate
oleic acid + ATP + CoA
oleoyl-CoA + AMP + diphosphate
-
-
-
-
?
additional information
?
-
ATP + (R)-ibuprofen + CoA
AMP + diphosphate + (R)-ibuprofenoyl-CoA
-
9% of the activity with palmitate
-
?
ATP + (R)-ibuprofen + CoA
AMP + diphosphate + (R)-ibuprofenoyl-CoA
-
(R)-ibuprofenoyl-CoA synthetase and long-chain acyl-CoA synthetase are identical enzymes that are involved in the metabolism of various xenobiotics
-
?
ATP + a long-chain carboxylate + CoA
AMP + diphosphate + an acyl-CoA
-
-
-
-
?
ATP + a long-chain carboxylate + CoA
AMP + diphosphate + an acyl-CoA
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
the enzyme can elongate and desaturate fatty acids up to 22:6
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + an acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + an acyl-CoA
-
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
-
isoform Facl1 exhibits less than 10% activity and isoform Facl2 exhibits about 20% activity
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
-
isoform Facl1 exhibits less than 10% activity and isoform Facl2 exhibits about 20% activity
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
isoform Facl1 exhibits about 40% activity and isoform Facl2 exhibits about 60% activity
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
isoform Facl1 exhibits about 40% activity and isoform Facl2 exhibits about 60% activity
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
preferred substrate
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
preferred substrate of isoform ACSL4
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
preferred substrate
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
85% of the activity with palmitate
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
the activity with arachidonate is twice as high as with palmitate
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
-
isoform Facl1 exhibits about 20% activity and isoform Facl2 exhibits about 40% activity
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
-
isoform Facl1 exhibits about 20% activity and isoform Facl2 exhibits about 40% activity
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
-
-
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
-
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
-
-
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
-
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
-
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
Ulmus sp.
-
-
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
-
ineffective
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
-
-
-
-
?
ATP + docosahexaenoate + CoA
AMP + diphosphate + docosahexaenoyl-CoA
-
-
-
-
?
ATP + docosahexaenoate + CoA
AMP + diphosphate + docosahexaenoyl-CoA
preferred substrate of isoform ACSL6
-
-
?
ATP + docosahexaenoate + CoA
AMP + diphosphate + docosahexaenoyl-CoA
second best substrate
-
-
?
ATP + docosahexaenoate + CoA
AMP + diphosphate + docosahexaenoyl-CoA
-
-
-
-
?
ATP + docosahexaenoate + CoA
AMP + diphosphate + docosahexaenoyl-CoA
-
-
-
-
?
ATP + docosahexaenoate + CoA
AMP + diphosphate + docosahexaenoyl-CoA
-
-
-
-
?
ATP + docosahexaenoate + CoA
AMP + diphosphate + docosahexaenoyl-CoA
-
-
-
?
ATP + dodecanoate + CoA
AMP + diphosphate + dodecanoyl-CoA
-
-
?
ATP + dodecanoate + CoA
AMP + diphosphate + dodecanoyl-CoA
-
-
-
?
ATP + eicosapentaenoate + CoA
AMP + diphosphate + eicosapentaenoyl-CoA
-
-
-
-
?
ATP + eicosapentaenoate + CoA
AMP + diphosphate + eicosapentaenoyl-CoA
-
-
-
?
ATP + eicosapentaenoate + CoA
AMP + diphosphate + eicosapentaenoyl-CoA
best substrate
-
-
?
ATP + eicosapentaenoate + CoA
AMP + diphosphate + eicosapentaenoyl-CoA
best substrate
-
-
?
ATP + eicosapentaenoate + CoA
AMP + diphosphate + eicosapentaenoyl-CoA
-
-
-
-
?
ATP + eicosapentaenoate + CoA
AMP + diphosphate + eicosapentaenoyl-CoA
-
-
-
-
?
ATP + eicosapentaenoate + CoA
AMP + diphosphate + eicosapentaenoyl-CoA
-
-
-
?
ATP + fatty acid + 4'-phosphopantetheine
AMP + diphosphate + acyl-4'-phosphopantetheine
-
-
-
-
?
ATP + fatty acid + 4'-phosphopantetheine
AMP + diphosphate + acyl-4'-phosphopantetheine
-
-
-
-
?
ATP + fatty acid + dephospho-CoA
AMP + diphosphate + acyl-dephospho-CoA
-
-
-
?
ATP + fatty acid + dephospho-CoA
AMP + diphosphate + acyl-dephospho-CoA
-
-
-
-
?
ATP + fatty acid + dephospho-CoA
AMP + diphosphate + acyl-dephospho-CoA
-
-
-
-
?
ATP + fatty acid + dephospho-CoA
AMP + diphosphate + acyl-dephospho-CoA
-
-
-
-
?
ATP + fatty acid + pantetheine
AMP + diphosphate + acyl-pantetheine
-
-
-
-
?
ATP + fatty acid + pantetheine
AMP + diphosphate + acyl-pantetheine
-
-
-
-
?
ATP + heptadecanoate + CoA
AMP + diphosphate + heptadecanoyl-CoA
-
-
-
-
?
ATP + heptadecanoate + CoA
AMP + diphosphate + heptadecanoyl-CoA
-
-
-
?
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
-
-
?
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
-
-
-
-
?
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
-
-
-
-
?
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
-
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
-
-
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
-
4% of the activity with palmitate
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
high activity
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
high activity
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
Ulmus sp.
-
-
-
-
?
ATP + laurate + CoA
AMP + diphosphate + lauroyl-CoA
-
-
-
-
?
ATP + lignocerate + CoA
AMP + diphosphate + lignoceroyl-CoA
-
-
-
?
ATP + lignocerate + CoA
AMP + diphosphate + lignoceroyl-CoA
-
-
-
-
?
ATP + lignocerate + CoA
AMP + diphosphate + lignoceroyl-CoA
-
-
-
?
ATP + lignocerate + CoA
AMP + diphosphate + lignoceroyl-CoA
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
-
?
ATP + linoleate + CoA
AMP + diphosphate + linoleoyl-CoA
-
-
-
?
ATP + linolenate + CoA
AMP + diphosphate + linolenoyl-CoA
-
-
-
-
?
ATP + linolenate + CoA
AMP + diphosphate + linolenoyl-CoA
-
-
-
-
?
ATP + linolenate + CoA
AMP + diphosphate + linolenoyl-CoA
-
-
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
enzyme plays a pivotal role in cellular homeostasis, particular in lipid metabolism
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
activates exogenous long-chain fatty acids concomitant with their transport across the inner membrane into metabolically active CoA thioesters
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
essential role in animal cell proliferation
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
physiological significance of enzyme in fatty acid metabolism
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
enzyme is essential for both oxidation and esterification of fatty acids
-
-
?
ATP + long-chain carboxylic acid + CoA
?
the presence in the brain of multiple forms of enzyme with different fatty acid specificity is of considerable biological significance for controlling the synthesis of brain lipids. ACS3 mRNA is detectable 5 days after birth, increases to a maximum level at 15 days, and then decreases gradually to 10% of its maximum level in the adult
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
at 36°C the enzyme is required for the utilization of exogenous myristate by the N-myristoyltransferase. This requirement is not apparent at 24°C or 30°C, suggesting that another acylCoA synthetase activity with differing chain length and/or temperature optima exists
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
acyl-CoA synthetase I is responsible for the production of long-chain acyl-CoA that is utilized solely for the synthesis of cellular lipids, while the acyl-CoA synthetase II provides long-chain acyl-CoA that is exclusively degraded via beta-oxidation
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
no activity with 18:1 and 22:1 fatty acid
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
active on fatty acids with chain length of 6 to 18 carbon atoms, and a maximum activity with laurate. Low affinity for the fatty acids C6 to C8
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
trans-DELTA9-18:1 fatty acid
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
trans-DELTA9-16:1 fatty acid
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
optimal activity at 12:0 with saturated fatty acids as substrate, at 14:1 with mono-unsaturated fatty acids. The mono-unsaturated fatty acids from 14:1 to 22:1 give higher activity than the corresponding saturated fatty acids. Position of the double bond and the cis/trans configuration have little effect on the velocity values except for 22:1(11) (cis) which reveals a 2fold higher activity than 22:1(13)(cis) fatty acid. Polyunsaturated fatty acid 22:6(all cis) is a much better substrate than other C22 fatty acids
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
18:3(n-3)
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
18:1
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
substrate specificity of microsomal and mitochondrial enzyme are indistinguishable
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
among the saturated fatty acids highest activity is obtained with 12:0 fatty acid, monounsaturated fatty acids (16:1, 18:1, 20:1 and 22:1) are equally good or slightly better substrates than the corresponding saturated fatty acids, polyunsaturated fatty acids are rather poor substrates
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
utilizes laurate and myristate most efficientyl among C8-C22 saturated fatty acids and arachidonate and eicosapentaenoate among the C16-C20 unsaturated fatty acids
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
20:3(n-6)
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
Ulmus sp.
-
no activity with 18:1 and 22:1 fatty acid
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
utilizes straight-chain fatty acids with 14-18 carbon atoms regardless of the degree of unsaturation. Straight-chain fatty acids containing more than 18 or fewer than 14 carbon atoms, as well as 16-hydroxypalmitic acid and hexadecanedioic acid are ineffective. Acyl-CoA synthetase II has a broader fatty acid specificity than acyl-CoA synthetase I. The effective substrates include long-chain dicarboxylic acids
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
18:1
-
-
?
ATP + long-chain carboxylic acid + CoA
AMP + diphosphate + long-chain acyl-CoA
-
no activity with 18:1 and 22:1 fatty acid
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
isoform Facl1 exhibits about 65% activity and isoform Facl2 exhibits about 85% activity
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
Ulmus sp.
-
-
-
-
?
ATP + myristate + CoA
AMP + diphosphate + myristoyl-CoA
-
-
-
-
?
ATP + o-succinyl-1-benzoate + CoA
AMP + diphosphate + o-succinyl-1-benzoyl-CoA
-
a step in the bacterial biosynthesis of menaquinone from chorismate, pathway overview
-
-
?
ATP + o-succinyl-1-benzoate + CoA
AMP + diphosphate + o-succinyl-1-benzoyl-CoA
-
a two-step reaction via o-succinyl-1-benzoyl-AMP intermediate
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
-
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
-
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
-
-
?
ATP + octanoate + CoA
AMP + diphosphate + octanoyl-CoA
-
-
-
-
?
ATP + octanoate + CoA
AMP + diphosphate + octanoyl-CoA
-
-
-
?
ATP + octanoate + CoA
AMP + diphosphate + octanoyl-CoA
-
-
-
-
?
ATP + octanoate + CoA
AMP + diphosphate + octanoyl-CoA
-
-
-
-
?
ATP + octanoate + CoA
AMP + diphosphate + octanoyl-CoA
-
20% of the activity with palmitate
-
?
ATP + octanoate + CoA
AMP + diphosphate + octanoyl-CoA
-
ineffective
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
isoform LACS7 has a much higher ratio of oleoyl-CoA to octanoyl-CoA synthetase activity compared to isoform LCS6
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
preferred substrate of isoform ACSL3
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
high activity
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
high activity
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + oleate + CoA
AMP + diphosphate + oleoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
most preferred substrate for isoform Facl2 (100% activity)
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
most preferred substrate for isoform Facl2 (100% activity)
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
highest activity on palmitate
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
highest activity on palmitate
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
highest activity
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
highest activity
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
Ulmus sp.
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitate + CoA
AMP + diphosphate + palmitoyl-CoA
-
-
-
-
?
ATP + palmitoleate + CoA
AMP + diphosphate + palmitoleoyl-CoA
-
-
-
-
?
ATP + palmitoleate + CoA
AMP + diphosphate + palmitoleoyl-CoA
-
-
-
-
?
ATP + palmitoleate + CoA
AMP + diphosphate + palmitoleoyl-CoA
-
-
-
?
ATP + palmitoleate + CoA
AMP + diphosphate + palmitoleoyl-CoA
-
-
-
-
?
ATP + palmitoleate + CoA
AMP + diphosphate + palmitoleoyl-CoA
-
-
-
-
?
ATP + pentadecanoate + CoA
AMP + diphosphate + pentadecanoyl-CoA
-
-
-
-
?
ATP + pentadecanoate + CoA
AMP + diphosphate + pentadecanoyl-CoA
-
-
-
?
ATP + stearate + CoA
AMP + diphosphate + stearoyl-CoA
-
-
-
-
?
ATP + stearate + CoA
AMP + diphosphate + stearoyl-CoA
-
-
-
-
?
ATP + stearate + CoA
AMP + diphosphate + stearoyl-CoA
-
-
-
-
?
ATP + stearate + CoA
AMP + diphosphate + stearoyl-CoA
-
-
-
-
?
ATP + stearate + CoA
AMP + diphosphate + stearoyl-CoA
-
-
-
?
ATP + stearate + CoA
AMP + diphosphate + stearoyl-CoA
-
-
-
-
?
ATP + stearate + CoA
AMP + diphosphate + stearoyl-CoA
-
-
-
-
?
ATP + tetradecanoate + CoA
AMP + diphosphate + tetradecanoyl-CoA
-
-
?
ATP + tetradecanoate + CoA
AMP + diphosphate + tetradecanoyl-CoA
-
-
-
?
ATP + tridecanoate + CoA
AMP + diphosphate + tridecanoyl-CoA
-
-
-
-
?
ATP + tridecanoate + CoA
AMP + diphosphate + tridecanoyl-CoA
-
-
-
?
ATP + undecanoate + CoA
AMP + diphosphate + undecanoyl-CoA
-
-
-
-
?
ATP + undecanoate + CoA
AMP + diphosphate + undecanoyl-CoA
-
-
-
?
dATP + fatty acid + CoA
dAMP + diphosphate + acyl-CoA
-
-
-
-
?
dATP + fatty acid + CoA
dAMP + diphosphate + acyl-CoA
-
-
-
-
?
decanoic acid + ATP + CoA
decanoyl-CoA + AMP + diphosphate
-
-
-
-
?
decanoic acid + ATP + CoA
decanoyl-CoA + AMP + diphosphate
-
-
-
-
?
lauric acid + ATP + CoA
lauroyl-CoA + AMP + diphosphate
-
-
-
-
?
lauric acid + ATP + CoA
lauroyl-CoA + AMP + diphosphate
-
-
-
-
?
linoleic acid + ATP + CoA
linoleoyl-CoA + AMP + diphosphate
-
-
-
?
linoleic acid + ATP + CoA
linoleoyl-CoA + AMP + diphosphate
-
-
-
-
?
luciferin + O2 + ATP
oxidized luciferin + CO2 + H2O + AMP + diphosphate + hv
-
-
-
-
?
luciferin + O2 + ATP
oxidized luciferin + CO2 + H2O + AMP + diphosphate + hv
-
the enzyme in peroxisomes may keep the catalytic functions in bioluminescence and fatty acid metabolism
-
-
?
luciferin + O2 + ATP
oxidized luciferin + CO2 + H2O + AMP + diphosphate + hv
-
-
-
-
?
luciferin + O2 + ATP
oxidized luciferin + CO2 + H2O + AMP + diphosphate + hv
-
the enzyme in peroxisomes may keep the catalytic functions in bioluminescence and fatty acid metabolism
-
-
?
myristic acid + ATP + CoA
myristoyl-CoA + AMP + diphosphate
-
-
-
-
?
myristic acid + ATP + CoA
myristoyl-CoA + AMP + diphosphate
-
-
-
-
?
additional information
?
-
-
lacs2-1 mutation results in a defective cutin layer
-
-
?
additional information
?
-
-
peroxisomal acyl-CoA synthetase activity is essential for seedling development
-
-
?
additional information
?
-
-
the OPC-8:CoA ligase catalyses an essential step in jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of the carboxylic acid side chain of its precursors, and, in accordance with this function, the protein is localized in peroxisomes
-
-
?
additional information
?
-
-
enzyme family members display activity towards different biosynthetic precursors of jasmonic acid, including 12-oxo-phytodienoic acid, i.e. OPDA, dinor-OPDA, 3-oxo-2(2'-[Z]-pentenyl)cyclopentane-1-octanoic acid, i.e. OPC-8, and OPC-6, substrate specificity of protein At1g20510 readily converting OPDA, dnOPDA, OPC-8, OPC-6, and myristic acid, OPC-8 is the preferred substrate, overview
-
-
?
additional information
?
-
-
Arabidopsis isoforms LACS1-3 display broad substrate specificities, ranging from saturated and monounsaturated C16, C18 and C20 fatty acids to saturated very-long-chain fatty acids
-
-
?
additional information
?
-
the enzyme ACS6 preferrs long-chain fatty acids that contain a cis-9 double bond
-
?
additional information
?
-
-
the enzyme plays a central role in intermediary metabolism by catalyzing the formation of acyl-CoA. The enzyme functions in the vectorial movement of exogenous fatty acids across the plasma membrane by acting as a metabolic trap, which results in the formation of acyl-CoA esters
-
?
additional information
?
-
-
fatty acyl-CoA synthetase facilitates long chain fatty acid permeation of the inner membrane by a vectorial thioesterification
-
-
?
additional information
?
-
-
unsaturated fatty acids such as 14:1, 16:1, 18:1, 22:1, 18:3(n-3), 20:3(n-6) fatty acids and arachidonic acid are no substrates of isoform Facl1 or Facl2
-
-
?
additional information
?
-
-
unsaturated fatty acids such as 14:1, 16:1, 18:1, 22:1, 18:3(n-3), 20:3(n-6) fatty acids and arachidonic acid are no substrates of isoform Facl1 or Facl2
-
-
?
additional information
?
-
-
low activity with laurate
-
-
?
additional information
?
-
-
the regulation of the FACL3/ACS3 expression by vitamin D3 is mediated by both androgen and androgen receptor, and suggests that increased FACL3/ACS3 expression by vitamin D3 is one of the components associated with antiproliferative effect of 1alpha,25(OH)2D3 in androgen receptor-positive prostate cancer LNCaP cells
-
-
?
additional information
?
-
-
octanoate and decanoate are ineffective substrates
-
-
?
additional information
?
-
-
no fatty acyl-CoA synthetase activity with octanoic acid and palmitic acid
-
-
?
additional information
?
-
-
lipidosin may mediate the link between adrenoleukodystrophy protein dysfunction and the impairment of fatty acid metabolism in Xlinked adrenoleukodystrophy
-
?
additional information
?
-
-
in vivo the loss of FATP4-mediated very long chain fatty acid uptake and/or esterification may underlie the null phenotype
-
-
?
additional information
?
-
-
inhibition of ACSL1 activity in adipocytes impairs fatty acid uptake, suggesting that esterification is essential for fatty acid transport. A constitutive interaction between the fatty acid transport protein FATP1 and ACSL1 contributes to efficient cellular uptake of long chain fatty acids in adipocytes through vectorial acylation
-
-
?
additional information
?
-
-
transcription of GR-LACS gene requires an Sp1/Sp3 binding element downstream of the transcriptional start sites which is essential for basal activity
-
-
?
additional information
?
-
no activity for lignoceric acid
-
-
?
additional information
?
-
-
no activity for lignoceric acid
-
-
?
additional information
?
-
-
the acyl-CoA synthetase is involved in bacterial menaquinone biosynthesis
-
-
?
additional information
?
-
-
the enzyme shows very low activity with acetate, propionate, butyrate, valerate, and caprylate
-
-
?
additional information
?
-
-
the enzyme shows very low activity with acetate, propionate, butyrate, valerate, and caprylate
-
-
?
additional information
?
-
low activity with caprate, laurate, myristate, eicosanoate, and docosanoate
-
-
?
additional information
?
-
low activity with caprate, laurate, myristate, eicosanoate, and docosanoate
-
-
?
additional information
?
-
-
no fatty acyl-CoA synthetase activity with octanoic acid and palmitic acid
-
-
?
additional information
?
-
firefly luciferase has two catalytic functions, it can act as a monooxygenase, luciferase, EC 1.13.12.7, but can also synthesize a long-chain fatty acyl-CoA from various long-chain fatty acids in the presence of ATP, CoA and Mg2+
-
-
?
additional information
?
-
FadD1 has a substrate preference for long-chain fatty acids, while FadD2 prefers shorter-chain fatty acids
-
-
?
additional information
?
-
FadD1 has a substrate preference for long-chain fatty acids, while FadD2 prefers shorter-chain fatty acids
-
-
?
additional information
?
-
-
FadD1 has a substrate preference for long-chain fatty acids, while FadD2 prefers shorter-chain fatty acids
-
-
?
additional information
?
-
the enzyme also forms a carbon-nitrogen bond, reaction of EC 6.3.1 acid-ammonia (or amide) ligase, i.e. amide synthase, and EC 6.3.2 acid-amino acid ligase, i.e. peptide synthase, comprising the amino group of the cysteine and the carboxyl group of the acid, overview
-
-
?
additional information
?
-
the enzyme also forms a carbon-nitrogen bond, reaction of EC 6.3.1 acid-ammonia (or amide) ligase, i.e. amide synthase, and EC 6.3.2 acid-amino acid ligase, i.e. peptide synthase, comprising the amino group of the cysteine and the carboxyl group of the acid, overview
-
-
?
additional information
?
-
no activity for the very long chain fatty acid, lignoceric acid, and a medium chain fatty acid, decanoic acid
-
?
additional information
?
-
-
ACS1, ACS4 and ACS5 are regulated independently by fasting and refeeding. Fasting rats for 48 h results in a decrease in ACS4 protein and an increase in ACS5. ACS1 and ACS4 may be functionally channeled to specific metabolic pathways though different ACS isoforms in unique subcellular locations
-
?
additional information
?
-
-
Acsl6 functions primarily in docosagexaenoic acid metabolism, its overexpression increases docosahexaenoic acid and arachidonic acid internalization primarily during the first 24 h of neuronal differentiation to stimulate phospholipid and enhance neurite outgrowth
-
-
?
additional information
?
-
-
high glucose concentration and insulin induce ACS-5 expression. The effect of insulin is mediated by SREBP-1c. ACS-5 is involved in anabolism of fatty acids
-
-
?
additional information
?
-
-
it is hypothesized that the enzyme plays an important role in targeting free fatty acids to specific metabolic pathways or acylation sites in the cell, thus acting as an important control mechanism in fuel partitioning. Localization of the enzyme at the plasma membrane may serve to decrease free fatty acid efflux and trap free fatty acids within the cell as long-chain acyl CoA
-
-
?
additional information
?
-
no activity for lignoceric acid
-
-
?
additional information
?
-
-
luciferase shows beetle luciferase may have arisen from a process of subfunctionalization as opposed to neofunctionalization early on in the evolution of the Elateroidea
-
-
?
additional information
?
-
-
TbACS1 prefers saturated fatty acids in the range undecanoate to tetradecanoate, TbACS3 and 4, which have 95% sequence identity, have similar specificities favouring fatty acids between tetradecanoate and heptadecanoate. In addition TbACS1, 3 and 4 function well with a variety of unsaturated fatty acids
-
?
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ATP + (R)-ibuprofen + CoA
AMP + diphosphate + (R)-ibuprofenoyl-CoA
-
(R)-ibuprofenoyl-CoA synthetase and long-chain acyl-CoA synthetase are identical enzymes that are involved in the metabolism of various xenobiotics
-
?
ATP + a long-chain carboxylate + CoA
AMP + diphosphate + an acyl-CoA
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain fatty acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + an acyl-CoA
ATP + acylate + CoA
AMP + diphosphate + acyl-CoA
-
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
ATP + long-chain carboxylic acid + CoA
?
ATP + o-succinyl-1-benzoate + CoA
AMP + diphosphate + o-succinyl-1-benzoyl-CoA
-
a step in the bacterial biosynthesis of menaquinone from chorismate, pathway overview
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
luciferin + O2 + ATP
oxidized luciferin + CO2 + H2O + AMP + diphosphate + hv
additional information
?
-
ATP + a long-chain carboxylate + CoA
AMP + diphosphate + an acyl-CoA
-
-
-
-
?
ATP + a long-chain carboxylate + CoA
AMP + diphosphate + an acyl-CoA
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
the enzyme can elongate and desaturate fatty acids up to 22:6
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + a long-chain acyl-CoA
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + an acyl-CoA
-
-
-
-
?
ATP + a long-chain fatty acid + CoA
AMP + diphosphate + an acyl-CoA
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
-
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
preferred substrate
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
preferred substrate
-
-
?
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
-
-
-
-
?
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
-
-
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
enzyme plays a pivotal role in cellular homeostasis, particular in lipid metabolism
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
activates exogenous long-chain fatty acids concomitant with their transport across the inner membrane into metabolically active CoA thioesters
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
essential role in animal cell proliferation
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
physiological significance of enzyme in fatty acid metabolism
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
enzyme is essential for both oxidation and esterification of fatty acids
-
-
?
ATP + long-chain carboxylic acid + CoA
?
the presence in the brain of multiple forms of enzyme with different fatty acid specificity is of considerable biological significance for controlling the synthesis of brain lipids. ACS3 mRNA is detectable 5 days after birth, increases to a maximum level at 15 days, and then decreases gradually to 10% of its maximum level in the adult
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
at 36°C the enzyme is required for the utilization of exogenous myristate by the N-myristoyltransferase. This requirement is not apparent at 24°C or 30°C, suggesting that another acylCoA synthetase activity with differing chain length and/or temperature optima exists
-
-
?
ATP + long-chain carboxylic acid + CoA
?
-
acyl-CoA synthetase I is responsible for the production of long-chain acyl-CoA that is utilized solely for the synthesis of cellular lipids, while the acyl-CoA synthetase II provides long-chain acyl-CoA that is exclusively degraded via beta-oxidation
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
-
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
-
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
-
-
?
luciferin + O2 + ATP
oxidized luciferin + CO2 + H2O + AMP + diphosphate + hv
-
the enzyme in peroxisomes may keep the catalytic functions in bioluminescence and fatty acid metabolism
-
-
?
luciferin + O2 + ATP
oxidized luciferin + CO2 + H2O + AMP + diphosphate + hv
-
the enzyme in peroxisomes may keep the catalytic functions in bioluminescence and fatty acid metabolism
-
-
?
additional information
?
-
-
lacs2-1 mutation results in a defective cutin layer
-
-
?
additional information
?
-
-
peroxisomal acyl-CoA synthetase activity is essential for seedling development
-
-
?
additional information
?
-
-
the OPC-8:CoA ligase catalyses an essential step in jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of the carboxylic acid side chain of its precursors, and, in accordance with this function, the protein is localized in peroxisomes
-
-
?
additional information
?
-
-
the enzyme plays a central role in intermediary metabolism by catalyzing the formation of acyl-CoA. The enzyme functions in the vectorial movement of exogenous fatty acids across the plasma membrane by acting as a metabolic trap, which results in the formation of acyl-CoA esters
-
?
additional information
?
-
-
fatty acyl-CoA synthetase facilitates long chain fatty acid permeation of the inner membrane by a vectorial thioesterification
-
-
?
additional information
?
-
-
the regulation of the FACL3/ACS3 expression by vitamin D3 is mediated by both androgen and androgen receptor, and suggests that increased FACL3/ACS3 expression by vitamin D3 is one of the components associated with antiproliferative effect of 1alpha,25(OH)2D3 in androgen receptor-positive prostate cancer LNCaP cells
-
-
?
additional information
?
-
-
lipidosin may mediate the link between adrenoleukodystrophy protein dysfunction and the impairment of fatty acid metabolism in Xlinked adrenoleukodystrophy
-
?
additional information
?
-
-
in vivo the loss of FATP4-mediated very long chain fatty acid uptake and/or esterification may underlie the null phenotype
-
-
?
additional information
?
-
-
inhibition of ACSL1 activity in adipocytes impairs fatty acid uptake, suggesting that esterification is essential for fatty acid transport. A constitutive interaction between the fatty acid transport protein FATP1 and ACSL1 contributes to efficient cellular uptake of long chain fatty acids in adipocytes through vectorial acylation
-
-
?
additional information
?
-
-
transcription of GR-LACS gene requires an Sp1/Sp3 binding element downstream of the transcriptional start sites which is essential for basal activity
-
-
?
additional information
?
-
-
the acyl-CoA synthetase is involved in bacterial menaquinone biosynthesis
-
-
?
additional information
?
-
firefly luciferase has two catalytic functions, it can act as a monooxygenase, luciferase, EC 1.13.12.7, but can also synthesize a long-chain fatty acyl-CoA from various long-chain fatty acids in the presence of ATP, CoA and Mg2+
-
-
?
additional information
?
-
FadD1 has a substrate preference for long-chain fatty acids, while FadD2 prefers shorter-chain fatty acids
-
-
?
additional information
?
-
FadD1 has a substrate preference for long-chain fatty acids, while FadD2 prefers shorter-chain fatty acids
-
-
?
additional information
?
-
-
FadD1 has a substrate preference for long-chain fatty acids, while FadD2 prefers shorter-chain fatty acids
-
-
?
additional information
?
-
-
ACS1, ACS4 and ACS5 are regulated independently by fasting and refeeding. Fasting rats for 48 h results in a decrease in ACS4 protein and an increase in ACS5. ACS1 and ACS4 may be functionally channeled to specific metabolic pathways though different ACS isoforms in unique subcellular locations
-
?
additional information
?
-
-
Acsl6 functions primarily in docosagexaenoic acid metabolism, its overexpression increases docosahexaenoic acid and arachidonic acid internalization primarily during the first 24 h of neuronal differentiation to stimulate phospholipid and enhance neurite outgrowth
-
-
?
additional information
?
-
-
high glucose concentration and insulin induce ACS-5 expression. The effect of insulin is mediated by SREBP-1c. ACS-5 is involved in anabolism of fatty acids
-
-
?
additional information
?
-
-
it is hypothesized that the enzyme plays an important role in targeting free fatty acids to specific metabolic pathways or acylation sites in the cell, thus acting as an important control mechanism in fuel partitioning. Localization of the enzyme at the plasma membrane may serve to decrease free fatty acid efflux and trap free fatty acids within the cell as long-chain acyl CoA
-
-
?
additional information
?
-
-
luciferase shows beetle luciferase may have arisen from a process of subfunctionalization as opposed to neofunctionalization early on in the evolution of the Elateroidea
-
-
?
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(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
-
competitive inhibitor of palmitoleic acid activation
2-Bromopalmitate
-
inhibition can be overcome by addition of phospholipid vesicles
2-bromopalmitoyl-CoA
-
inhibition can be overcome by addition of phospholipid vesicles
5'-deoxy-5'-[([(1E)-5-[2-(methoxycarbonyl)phenyl]-5-oxopent-1-en-1-yl]sulfonyl)amino]adenosine
-
mechanism of covalent inhibition
5'-deoxy-5'-[([(1E)-5-[2-(methoxycarbonyl)phenyl]hexa-1,5-dien-1-yl]sulfonyl)amino]adenosine
-
mechanism of covalent inhibition
5'-deoxy-5'-[([4-[2-(methoxycarbonyl)phenyl]-4-oxobutanoyl]sulfamoyl)amino]adenosine
-
mechanism of covalent inhibition
5'-deoxy-5'-[([4-[2-(methoxycarbonyl)phenyl]pent-4-enoyl]sulfamoyl)amino]adenosine
-
mechanism of covalent inhibition
5'-O-([4-[2-(methoxycarbonyl)phenyl]-4-oxobutanoyl]sulfamoyl)adenosine
-
mechanism of covalent inhibition
5'-O-([4-[2-(methoxycarbonyl)phenyl]pent-4-enoyl]sulfamoyl)adenosine
-
mechanism of covalent inhibition
Ag+
-
isoform Facl1 shows 64% residual activity and isoform Facl2 shows 71% residual activity at 1 mM
arachidonic acid
concentration above 10 microM
Brij 58
-
maximal inhibition at 4% detergent
cis-9,10-methylene octadecanoic acid
-
IC50: 0.025 mM for ACS1-Flag fusion protein, 0.03-0.04 mM for ACS4-Flag fusion protein, no effect on ACS5-Flag fusion protein
Co2+
-
isoform Facl1 shows 50% residual activity at 1 mM
Cu2+
-
isoform Facl1 shows 64% residual activity and isoform Facl2 shows 33% residual activity at 1 mM
docosahexaenoate
-
unlabeled, inhibition of docosahexaenoate activation
EDTA
-
isoform Facl1 shows 12% residual activity and isoform Facl2 shows 26% residual activity at 1 mM
Eicosa-11,14,17-trienoic acid
-
competitive inhibitor of palmitoleic acid activation
eicosa-8,11,14-trienoic acid
-
competitive inhibitor of palmitoleic acid activation
Eicosa-8,14-dienoic acid
-
competitive inhibitor of palmitoleic acid activation
eicosapentaenoate
-
inhibition of palmitoyl-CoA synthesis
Fe2+
-
isoform Facl1 shows 57% residual activity and isoform Facl2 shows 36% residual activity at 1 mM
GW1929
-
IC50: above 0.05 mM for ACS1-Flag fusion protein, 0.05 mM for ACS4-Flag fusion protein, no effect on ACS5-Flag fusion protein
Ketoprofen
-
non-competitive inhibition of the high affinity isoform
linoleate
-
inhibition of palmitoyl-CoA synthesis
linoleic acid
concentration above 10 microM
linolenate
-
inhibition of palmitoyl-CoA synthesis
Mn2+
-
isoform Facl1 shows 28% residual activity and isoform Facl2 shows 40% residual activity at 1 mM
naproxen
-
non-competitive inhibition of the high affinity isoform
Ni2+
-
isoform Facl1 shows 1.3% residual activity and isoform Facl2 shows no activity at 1 mM
oleate
-
inhibition of palmitoyl-CoA synthesis
oleic acid
concentration above 10 microM
oleoyl-CoA
-
inhibition of oleoyl-CoA synthesis
palmitate
-
linolenic acid activation
Perfluorodecanoic acid
-
no inhibition by short-chain perfluorinated fatty acids
Perfluorononanoic acid
-
no inhibition by short-chain perfluorinated fatty acids
Perfluorooctanoic acid
-
no inhibition by short-chain perfluorinated fatty acids
pioglitazone
-
IC50: 0.0015 mM for ACS1-Flag fusion protein, no effect on ACS4-Flag fusion protein and ACS5-Flag fusion protein
R-Fenoprofen
-
mixed inhibition of the high affinity isoform
R-Ibuprofen
-
mixed inhibition of the high affinity isoform
salts
-
at higher concentrations the chaotropic salts inhibit the enzyme activity, activity can be recovered by dilution. At low concentrations all salts, including the chaotropic salts and thelyotropic salts are equally effective in activation
-
sodium cholate
-
maximal inhibition at 1% detergent
triacsin
-
competitive inhibitor of both ACS1 and ACS4
Triacsins
-
hierarchy of inhibitory potency in decreasing order: triacsin C, triacsin A, triacsin D/ triacsin B
Tween 80
-
maximal inhibition at 4% detergent
Zn2+
-
isoform Facl1 shows 13% residual activity and isoform Facl2 shows 0.36% residual activity at 1 mM
Zwittergent 3-12
-
inhibition below the critical micellar concentration, 0.12%. below this concentrations no inhibition
arachidonate
inhibits palmitoyl-CoA synthesis at high concentrations
arachidonate
-
inhibition of palmitoyl-CoA synthesis
ATP
-
above 13.3 mM
diphosphate
-
low inhibition of oleoyl-CoA synthesis
fatty acids
-
saturated fatty acids do not inhibit activation of docosahexaenoate or palmitate. Unsaturated fatty acids, except nervonic acid, inhibit the activation of docosahexaenoate acid. Moderate inhibition by oleate, linoleate, eicosapentanoate, and palmitate
fatty acids
-
palmitoleate, oleate and linoleate are competitive inhibitors of the activation of each other
NEM
-
strongly inhibits ACS5 and weakly inhibits ACS1, no effect on ACS5
rosiglitazone
-
IC50: 0.0005 mM for ACS1-Flag fusion protein, no effect on ACS4-Flag fusion protein and ACS5-Flag fusion protein
SDS
-
isoform Facl1 shows 1.3% residual activity and isoform Facl2 shows 2.6% residual activity at 0.05% (w/v)
thiazolidinediones
-
thiazolidinediones
-
specific inhibitors of ACS4
Triacsin A
-
isolated from the culture filtrate of Streptomyces sp. SK-1894, the anti-atherosclerotic agent acts as selective enzyme inhibitor, it inhibits the synthesis of cholesteryl ester and triacylglycerol in peritoneal macrophages
Triacsin A
-
non-competitive with respect to ATP and coenzyme A
Triacsin A
-
non-competitive with respect to ATP and coenzyme A
Triacsin C
-
competitive inhibitor of palmitate binding for microsomal and mitochondrial enzyme, uncompetitive inhibitor versus CoA. Biphasic Dixon plot, a high-affinity site with a Ki of 0.0001 mM accounts for a maximum of 70% of the inhibition. A low affinity site with a Ki of 0.006 mM accounts for a maximum of 30% inhibition
Triacsin C
-
significant inhibition
Triacsin C
95% inhibition at 0.005 mM
Triacsin C
-
i.e. 1-hydroxy-3-(E,E,E-2',4',7'-undecatrienylidine)triazene, potent competitive inhibitor
Triacsin C
-
in intact cultured cells the inhibition of arachidonoyl-CoA synthetase, EC 6.2.1.15, is much greater than the inhibition of nonspecific acyl-CoA synthetase
Triacsin C
-
no effect on FATP4 acyl-CoA synthetase activity towards n-tetracosanoic acid, inhibits activity with palmitate with IC50 of 0.03 mM
Triacsin C
-
90% inhibition at 0.02 mM
Triacsin C
-
isolated from the culture filtrate of Streptomyces sp. SK-1894, the anti-atherosclerotic agent acts as selective enzyme inhibitor, it inhibits the synthesis of cholesteryl ester and triacylglycerol in peritoneal macrophages
Triacsin C
-
strongly inhibits ACS1 and ACS4, no effect on ACS5
Triacsin C
IC50: 0.0055 mM
Triton X-100
-
Inhibition of acyl-CoA formation, inhibits ACSL6 isoform 2 (F-Gate) and its N-terminus truncated version, DELTAN-(F-Gate)
Triton X-100
-
slight inhibition when incubated with microsomes at 0°C for 30 min
Triton X-100
-
maximal inhibition at 4% detergent
troglitazone
-
no effect on FATP4 acyl-CoA synthetase activity towards n-tetracosanoic acid up to 0.05 mM, inhibits activity with palmitate with IC50 of 0.02 mM
troglitazone
0.05 mM, 5% inhibition
troglitazone
-
IC50: 0.0015 mM for ACS1-Flag fusion protein, no effect on ACS4-Flag fusion protein and ACS5-Flag fusion protein
additional information
-
not inhibited by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol
-
additional information
-
an ACSL6 construct with a tag at its C-terminus has a far lower activity than a construct with a tag fused to its N-terminus
-
additional information
not inhibited by thiazolidinediones; not inhibited by thiazolidinediones; not inhibited by triacsin C; not inhibited by triacsin C; not inhibited by triacsin C
-
additional information
not inhibited by thiazolidinediones; not inhibited by thiazolidinediones; not inhibited by triacsin C; not inhibited by triacsin C; not inhibited by triacsin C
-
additional information
not inhibited by thiazolidinediones; not inhibited by thiazolidinediones; not inhibited by triacsin C; not inhibited by triacsin C; not inhibited by triacsin C
-
additional information
not inhibited by thiazolidinediones; not inhibited by thiazolidinediones; not inhibited by triacsin C; not inhibited by triacsin C; not inhibited by triacsin C
-
additional information
not inhibited by thiazolidinediones; not inhibited by thiazolidinediones; not inhibited by triacsin C; not inhibited by triacsin C; not inhibited by triacsin C
-
additional information
-
not inhibited by thiazolidinediones; not inhibited by thiazolidinediones; not inhibited by triacsin C; not inhibited by triacsin C; not inhibited by triacsin C
-
additional information
-
design and construction of mechanism-based inhibitors of MenE
-
additional information
-
3-phenoxybenzoic acid, p-coumaric acid, ibuprofen, ferulic acid and firefly luciferin, at concentrations up to 0.05 mM have no effect on three ACS isoenzymes
-
additional information
isoenzyme ACSL3 maintains activity in presence of 2-3 mM Triton X-100. Isoenzyme ACSL6_v1 is insensitive to rosiglitazone; isoenzyme ACSL6_v1 maintains activity in presence of 2-3 mM Triton X-100. Isoenzyme ACSL6_v1 is insensitive to rosiglitazone and is not affected by triacsin C up to concentrations of 0.05 mM; isoenzyme ACSL6_v2 maintains optimal activity up to 4 mM Triton X-100. Isoenzyme ACSL6_v2 is insensitive to rosiglitazone and is not affected by triacsin C up to concentrations of 0.05 mM
-
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.